(Q37600564)

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The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers--functional relevance and a hypothesis on innate reactions to skin sensitizers.

scientific article published on 18 September 2009

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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Europe PubMed Central

The Nrf2-Keap1-ARE toxicity pathway as a cellular sensor for skin sensitizers--functional relevance and a hypothesis on innate reactions to skin sensitizers (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

author name string

Andreas Natsch

1

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21 August 2017

publication date

18 September 2009

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Toxicological Sciences

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

113

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8 February 2020

2

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8 February 2020

284-292

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8 February 2020

Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment.

1 reference

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21 January 2018

Local lymph node assay - validation, conduct and use in practice

1 reference

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A skin-like cytochrome P450 cocktail activates prohaptens to contact allergenic metabolites

1 reference

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21 January 2018

Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity.

1 reference

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21 January 2018

The role of Keap1 in cellular protective responses

1 reference

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21 January 2018

Development of a peptide reactivity assay for screening contact allergens

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

A cell-based in vitro alternative to identify skin sensitizers by gene expression

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

PTEN acetylation modulates its interaction with PDZ domain

1 reference

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21 January 2018

A future approach to measuring relative skin sensitising potency: a proposal

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Dendritic cells and skin sensitisation hazard assessment

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Analysis of differential gene expression in auricular lymph nodes draining skin exposed to sensitizers and irritants

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Induction of AKR1C2 by phase II inducers: identification of a distal consensus antioxidant response element regulated by NRF2.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Role of protein haptenation in triggering maturation events in the dendritic cell surrogate cell line THP-1.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

LPS, TLR4 and infectious disease diversity.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Role of MAPK signaling pathway in the activation of dendritic type cell line, THP-1, induced by DNCB and NiSO4.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Nrf2-Keap1 defines a physiologically important stress response mechanism

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Covalent modification of lysine residues by allyl isothiocyanate in physiological conditions: plausible transformation of isothiocyanate from thiol to amine.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

A conjugated diene identified as a prohapten: contact allergenic activity and chemical reactivity of proposed epoxide metabolites

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

PCAF modulates PTEN activity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Assessment of the U937 cell line for the detection of contact allergens

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Mechanistic applicability domains for non-animal based prediction of toxicological endpoints. QSAR analysis of the schiff base applicability domain for skin sensitization.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

High throughput kinetic profiling approach for covalent binding to peptides: application to skin sensitization potency of Michael acceptor electrophiles.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Genome-wide transcriptional responses to acrolein

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Activation of the Nrf2/antioxidant response pathway increases IL-8 expression

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFP228

21 January 2018

Identifiers

10.1093/TOXSCI/KFP228

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19767620%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

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