(Q37611164)

21 August 2017

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title

Deceptively simple but simply deceptive--Caenorhabditis elegans lifespan studies: considerations for aging and antioxidant effects (English)

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21 August 2017

Caenorhabditis elegans

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4

Barry Halliwell

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21 August 2017

Jan Gruber

1

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21 August 2017

Li Fang Ng

series ordinal

2

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21 August 2017

Suresh Kumar Poovathingal

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

5 October 2009

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21 August 2017

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21 August 2017

583

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21 August 2017

21

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21 August 2017

3377-3387

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Pharmacological intervention in invertebrate aging.

21 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The embryonic cell lineage of the nematode Caenorhabditis elegans

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Genome sequence of the nematode C. elegans: a platform for investigating biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Specific interference by ingested dsRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Non-ageing developmental variant of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Studies on aging in Nematodes. I. The nematode as a model organism for aging research

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Mechanisms of ageing: public or private?

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The plasticity of aging: insights from long-lived mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The mitochondrial free radical theory of ageing--where do we stand?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Cells discover fire: employing reactive oxygen species in development and consequences for aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Aging and resistance to oxidative damage in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The role of ubiquinone in Caenorhabditis elegans longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

A systematic RNAi screen for longevity genes in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Uncoupling to survive? The role of mitochondrial inefficiency in ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Effects of superoxide dismutase/catalase mimetics on life span and oxidative stress resistance in the housefly, Musca domestica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The longevity of Caenorhabditis elegans in soil

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Genetic analysis of life-span in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Arresting development arrests aging in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

A simple method for maintaining large, aging populations of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Temperature-sensitive developmental mutants of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Principles of animal use for gerontological research

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Dietary restriction in the nematode Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Caloric restriction in humans: potential pitfalls and health concerns

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Hormesis and aging in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Effect of colour of drugs: systematic review of perceived effect of drugs and of their effectiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

An automated high-throughput assay for survival of the nematode Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Automated assays to study longevity in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Visualizing hidden heterogeneity in isogenic populations of C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Compounds that confer thermal stress resistance and extended lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Advantages and disadvantages of Caenorhabditis elegans for aging research.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Anticonvulsant medications extend worm life-span

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Two neurons mediate diet-restriction-induced longevity in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional chinese medicines

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Psoralea corylifolia L. inhibits mitochondrial complex I and proteasome activities in SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Direct observation of stress response in Caenorhabditis elegans using a reporter transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Limited antioxidant effect after consumption of a single dose of tomato sauce by young males, despite a rise in plasma lycopene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The wanderings of a free radical

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Rates of behavior and aging specified by mitochondrial function during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Non-antioxidant molecular functions of alpha-tocopherol (vitamin E).

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Mitochondrial influence on aging rate in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Plant adaptogens increase lifespan and stress resistance in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

A steroid hormone that extends the lifespan of Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Effects of a potent antioxidant, platinum nanoparticle, on the lifespan of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

An antidepressant that extends lifespan in adult Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Benchmarks for ageing studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

A small-molecule screen in C. elegans yields a new calcium channel antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2009.09.051

10.1016/J.FEBSLET.2009.09.051

21 January 2018

Identifiers

DOI

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21 August 2017

1 reference