(Q37613037)

English

The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families

scientific article published on February 2010

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

1 reference

Europe PubMed Central

The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families (English)

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

crystal structure

1 reference

based on heuristic

inferred from title

Matthew R Redinbo

3

object named as

Matthew R Redinbo

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

author name string

Anna Radominska-Pandya

1

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

Stacie M Bratton

2

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

Michael J Miley

4

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

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publication date

1 February 2010

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Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

Drug Metabolism Reviews

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

42

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

1

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

133-144

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

Substrate specificity of plant UDP-dependent glycosyltransferases predicted from crystal structures and homology modeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Catalytic key amino acids and UDP-sugar donor specificity of a plant glucuronosyltransferase, UGT94B1: molecular modeling substantiated by site-specific mutagenesis and biochemical analyses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structure of Medicago truncatula UGT85H2--insights into the structural basis of a multifunctional (iso)flavonoid glycosyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Phenylalanine 90 and 93 are localized within the phenol binding site of human UDP-glucuronosyltransferase 1A10 as determined by photoaffinity labeling, mass spectrometry, and site-directed mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Structures and mechanisms of glycosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structure of vancosaminyltransferase GtfD from the vancomycin biosynthetic pathway: interactions with acceptor and nucleotide ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structures of the T4 phage beta-glucosyltransferase and the D100A mutant in complex with UDP-glucose: glucose binding and identification of the catalytic base for a direct displacement mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

An evolving hierarchical family classification for glycosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structure of the MurG:UDP-GlcNAc complex reveals common structural principles of a superfamily of glycosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Remarkable structural similarities between diverse glycosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structure of beta 1,3-glucuronyltransferase I in complex with active donor substrate UDP-GlcUA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

High resolution crystal structures of T4 phage beta-glucosyltransferase: induced fit and effect of substrate and metal binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Glycosyltransferase structure and mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

The 1.9 Å crystal structure ofEscherichia coliMurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Structural and functional studies of UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Crystal structure of the DNA modifying enzyme beta-glucosyltransferase in the presence and absence of the substrate uridine diphosphoglucose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Lithocholate glucuronide is a cholestatic agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Rat liver UDP-glucuronosyltransferase. Identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and beta-estradiol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Rat liver UDP-glucuronosyltransferase. Sequence and expression of a cDNA encoding a phenobarbital-inducible form

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Metabolic polymorphisms affecting activation of toxic and mutagenic arylamines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

23 August 2017

Arginine 52 and histidine 54 located in a conserved amino-terminal hydrophobic region (LX2-R52-G-H54-X3-V-L) are important amino acids for the functional and structural integrity of the human liver UDP-glucuronosyltransferase UGT1*6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

6 September 2017

Influence of N-terminal domain histidine and proline residues on the substrate selectivities of human UDP-glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

14 September 2017

Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

14 September 2017

Expression of a functionally active human hepatic UDP-glucuronosyltransferase (UGT1A6) lacking the N-terminal signal sequence in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

28 September 2017

Mutational analysis of the carboxy-terminal region of UDP-glucuronosyltransferase 2B1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

28 September 2017

Required buried alpha-helical structure in the bilirubin UDP-glucuronosyltransferase, UGT1A1, contains a nonreplaceable phenylalanine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

25 June 2018

Structure and function of uridine diphosphate glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

25 June 2018

Topology and regulation of bilirubin UDP-glucuronyltransferase in sealed native microsomes from rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

25 June 2018

Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat mRNA for UDP-glucuronosyltransferase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

25 June 2018

An investigation of the transverse topology of bilirubin UDP-glucuronosyltransferase in rat hepatic endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

25 June 2018

Topological disposition of UDP-glucuronyltransferase in rat liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

25 June 2018

Identification of aspartic acid and histidine residues mediating the reaction mechanism and the substrate specificity of the human UDP-glucuronosyltransferases 1A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

1 September 2018

Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

1 September 2018

Opioids bind to the amino acids 84 to 118 of UDP-glucuronosyltransferase UGT2B7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

1 September 2018

Analysis of opioid binding to UDP-glucuronosyltransferase 2B7 fusion proteins using nuclear magnetic resonance spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

1 September 2018

Determinants of UDP glucuronosyltransferase membrane association and residency in the endoplasmic reticulum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3192453

1 September 2018

An internal signal sequence mediates the targeting and retention of the human UDP-glucuronosyltransferase 1A6 to the endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative modelling of the human UDP-glucuronosyltransferases: insights into structure and mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Steroid D-ring glucuronides: characterization of a new class of cholestatic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-free translation of mouse liver mRNA coding for two forms of UDP glucuronosyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of nascent UDP glucuronosyltransferase from rat liver by dog pancreatic microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19821783

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3109/03602530903209049

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 December 2017

http://europepmc.org/abstract/PMC/3192453

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

2 March 2018

http://europepmc.org/abstract/PMC/3192453

ResearchGate publication ID

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