(Q37615906)

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C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

scientific article published on 16 May 2013

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scholarly article

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Europe PubMed Central

PMC publication ID

21 August 2017

C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica (English)

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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monoclonal antibody

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author name string

Puay-Wah Phuan

1

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Europe PubMed Central

PMC publication ID

21 August 2017

Hua Zhang

2

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Europe PubMed Central

PMC publication ID

21 August 2017

Nithi Asavapanumas

3

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Europe PubMed Central

PMC publication ID

21 August 2017

Michael Leviten

4

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Europe PubMed Central

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21 August 2017

Arnon Rosenthal

5

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Europe PubMed Central

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21 August 2017

Lukmanee Tradtrantip

6

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Europe PubMed Central

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21 August 2017

A S Verkman

7

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21 August 2017

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16 May 2013

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21 August 2017

Acta Neuropathologica

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Europe PubMed Central

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21 August 2017

125

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Europe PubMed Central

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21 August 2017

6

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Europe PubMed Central

PMC publication ID

21 August 2017

829-840

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Europe PubMed Central

PMC publication ID

21 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3941651/fullTextXML

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Disease amelioration with tocilizumab in a treatment-resistant patient with neuromyelitis optica: implication for cellular immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Therapeutic cleavage of anti-aquaporin-4 autoantibody in neuromyelitis optica by an IgG-selective proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Interleukin 6 receptor blockade in patients with neuromyelitis optica nonresponsive to anti-CD20 therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Clinical efficacy of plasmapheresis in patients with neuromyelitis optica spectrum disorder and effects on circulating anti-aquaporin-4 antibody levels

1 reference

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23 August 2017

Current concept of neuromyelitis optica (NMO) and NMO spectrum disorders.

1 reference

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23 August 2017

Enzymatic deglycosylation converts pathogenic neuromyelitis optica anti-aquaporin-4 immunoglobulin G into therapeutic antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Aquaporin 4 and neuromyelitis optica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Monoclonal antibodies in the treatment of immune thrombocytopenic purpura (ITP).

1 reference

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23 August 2017

Complement-dependent cytotoxicity in neuromyelitis optica requires aquaporin-4 protein assembly in orthogonal arrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Ex vivo spinal cord slice model of neuromyelitis optica reveals novel immunopathogenic mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Complement: a key system for immune surveillance and homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction

1 reference

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23 August 2017

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Paths reunited: Initiation of the classical and lectin pathways of complement activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Complement regulators and inhibitory proteins

1 reference

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The role of the anaphylatoxins in health and disease

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23 August 2017

Targeting classical complement pathway to treat complement mediated autoimmune diseases

1 reference

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23 August 2017

Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica

1 reference

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23 August 2017

The alternative pathway of complement: a pattern recognition system

1 reference

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23 August 2017

The spectrum of neuromyelitis optica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

C1q and its growing family.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

Revised diagnostic criteria for neuromyelitis optica

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

23 August 2017

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel

1 reference

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23 August 2017

The role of complement in the development of systemic lupus erythematosus

1 reference

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23 August 2017

C1q, autoimmunity and apoptosis

1 reference

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23 August 2017

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica

1 reference

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23 August 2017

C1q: structure, function, and receptors

1 reference

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23 August 2017

Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

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6 September 2017

Neuromyelitis optica: potential roles for intravenous immunoglobulin

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Chapter 22: Hereditary and acquired angioedema

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Rituximab dosing and monitoring strategies in neuromyelitis optica patients: creating strategies for therapeutic success

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Integrative continuum: accelerating therapeutic advances in rare autoimmune diseases

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6 September 2017

Treatment of neuromyelitis optica: an evidence based review

1 reference

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6 September 2017

Autoimmunity in neuromyelitis optica and opticospinal multiple sclerosis: astrocytopathy as a common denominator in demyelinating disorders

1 reference

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6 September 2017

Complement and non-complement activating functions of C1q: a prototypical innate immune molecule

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6 September 2017

Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3941651

6 September 2017

Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica

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14 September 2017

Prediction of neuromyelitis optica attack severity by quantitation of complement-mediated injury to aquaporin-4-expressing cells.

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Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20.

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Eculizumab in AQP4-IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study.

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Progress and Trends in Complement Therapeutics

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1 September 2018

Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid.

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1 September 2018

Increase of complement fragment C5a in cerebrospinal fluid during exacerbation of neuromyelitis optica

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1 September 2018

Cytotoxic effect of neuromyelitis optica antibody (NMO-IgG) to astrocytes: an in vitro study

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1 September 2018

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1 September 2018

Neuromyelitis optica with clinical and histopathological involvement of the brain

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1 September 2018

Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis

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1 September 2018

Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis

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Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

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Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and alpha(v)beta3 integrins

1 reference

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https://pubmed.ncbi.nlm.nih.gov/23677375

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inferred from PubMed ID database lookup

Identifiers

10.1007/S00401-013-1128-3

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Europe PubMed Central

PMC publication ID

21 August 2017

release_toopjrlvm5ba3myjix3oerljby

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https://api.fatcat.wiki/v0/release/toopjrlvm5ba3myjix3oerljby

24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

21 August 2017

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