(Q37626412)

21 August 2017

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title

Osteoimmunology and the effects of the immune system on bone (English)

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21 August 2017

Hiroshi Takayanagi

1

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21 August 2017

language of work or name

English

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publication date

3 November 2009

1 reference

Nature Reviews Rheumatology

21 August 2017

published in

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21 August 2017

volume

5

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21 August 2017

issue

12

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21 August 2017

page(s)

667-676

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Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

21 August 2017

cites work

1 reference

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A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis

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Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis

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Osteoblastic cells are involved in osteoclast formation.

31 March 2020

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Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

31 March 2020

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Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

RANK-L and RANK: T cells, bone loss, and mammalian evolution

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Osteoclasts are essential for TNF-alpha-mediated joint destruction

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Denosumab in postmenopausal women with low bone mineral density

31 March 2020

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Effects of denosumab on bone mineral density and bone turnover in postmenopausal women

31 March 2020

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Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Activated T lymphocytes support osteoclast formation in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

How important are T cells in chronic rheumatoid synovitis?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

IL-4 and IL-12 Regulate Proteoglycan-Induced Arthritis Through Stat-Dependent Mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Identification of cell cycle-arrested quiescent osteoclast precursors in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Reciprocal cross-talk between RANKL and interferon-gamma-inducible protein 10 is responsible for bone-erosive experimental arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Treg cells suppress osteoclast formation: a new link between the immune system and bone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

PPAR-gamma regulates osteoclastogenesis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Calcineurin/NFAT signaling in osteoblasts regulates bone mass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Evidence of radiographic benefit of treatment with infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of data from the anti-tumor necrosis factor trial in rheumatoid arthritis with c

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Pathological role of osteoclast costimulation in arthritis-induced bone loss.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Dickkopf-1 is a master regulator of joint remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The IL-23/IL-17 axis in inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Cyclosporine and tacrolimus for the treatment of rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Effects of disease-modifying antirheumatic drugs and antiinflammatory cytokines on human osteoclastogenesis through interaction with receptor activator of nuclear factor kappaB, osteoprotegerin, and receptor activator of nuclear factor kappaB ligand

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Microenvironmental niches in the bone marrow required for B-cell development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Osteoimmunology: interplay between the immune system and bone metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

RANK is essential for osteoclast and lymph node development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Paget's disease of bone and genetic disorders of RANKL/OPG/RANK/NF-kappaB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2009.217

Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19884898

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19884898

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Matrix metalloproteinases 1, 2, and 3 from rheumatoid synovial cells are sufficient to destroy joints

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19884898

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2009.217

1 reference

21 August 2017

1 reference