(Q37627556)

21 August 2017

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title

Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? (English)

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21 August 2017

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1

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PubMed ID

19890334

21 August 2017

language of work or name

English

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publication date

5 November 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

897-903

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21 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrc2745

21 August 2017

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31 March 2020

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Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death

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Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase

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Caspase-2: vestigial remnant or master regulator?

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Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

31 March 2020

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Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

31 March 2020

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Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.

31 March 2020

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Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage

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A role for caspase 2 and PIDD in the process of p53-mediated apoptosis

31 March 2020

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c-Myc and caspase-2 are involved in activating Bax during cytotoxic drug-induced apoptosis

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Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.

31 March 2020

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Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice

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Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells

31 March 2020

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Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8

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Caspase-2 can function upstream of bid cleavage in the TRAIL apoptosis pathway

31 March 2020

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Death in the balance: alternative participation of the caspase-2 and -9 pathways in neuronal death induced by nerve growth factor deprivation.

31 March 2020

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Caspase-2 mediates neuronal cell death induced by beta-amyloid

31 March 2020

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31 March 2020

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Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2

31 March 2020

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Defects in regulation of apoptosis in caspase-2-deficient mice

31 March 2020

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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

31 March 2020

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31 March 2020

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Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions

31 March 2020

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The biochemical mechanism of caspase-2 activation

31 March 2020

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31 March 2020

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Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7.

31 March 2020

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Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain

31 March 2020

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The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

31 March 2020

1 reference

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway

31 March 2020

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Caspase-2 activation in the absence of PIDDosome formation

31 March 2020

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DNA damage- and stress-induced apoptosis occurs independently of PIDD

31 March 2020

1 reference

Sequential caspase-2 and caspase-8 activation upstream of mitochondria during ceramideand etoposide-induced apoptosis.

31 March 2020

1 reference

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

31 March 2020

1 reference

Caspase-2 triggers Bax-Bak-dependent and -independent cell death in colon cancer cells treated with resveratrol.

31 March 2020

1 reference

In situ trapping of activated initiator caspases reveals a role for caspase-2 in heat shock-induced apoptosis.

31 March 2020

1 reference

Docetaxel-induced apoptosis in melanoma cells is dependent on activation of caspase-2.

31 March 2020

1 reference

Caspase-2 is required for cell death induced by cytoskeletal disruption

31 March 2020

1 reference

Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.

31 March 2020

1 reference

Serial killers: ordering caspase activation events in apoptosis

31 March 2020

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Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3

31 March 2020

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Processing of the Nedd2 precursor by ICE-like proteases and granzyme B.

31 March 2020

1 reference

Caspase activation pathways: some recent progress

31 March 2020

1 reference

Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway

31 March 2020

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Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

31 March 2020

1 reference

Caspases: their intracellular localization and translocation during apoptosis.

31 March 2020

1 reference

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

31 March 2020

1 reference

Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis

31 March 2020

1 reference

The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila.

31 March 2020

1 reference

Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

31 March 2020

1 reference

Caspase-2 deficiency enhances aging-related traits in mice

31 March 2020

1 reference

Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype

31 March 2020

1 reference

Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci

31 March 2020

1 reference

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia

31 March 2020

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Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray

31 March 2020

1 reference

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

31 March 2020

2 references

31 March 2020

12 December 2020

Involvement of BH3-only proteins in hematologic malignancies

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Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

1 reference

DNA damage induces two distinct modes of cell death in ovarian carcinomas

31 March 2020

1 reference

Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death

31 March 2020

1 reference

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

31 March 2020

1 reference

DNA double-strand break repair: all's well that ends well

31 March 2020

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DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis

31 March 2020

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Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.

31 March 2020

1 reference

Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress

31 March 2020

1 reference

Gene expression profiling of metastatic brain cancer.

31 March 2020

1 reference

12 December 2020

Loss of caspase-2, -6 and -7 expression in gastric cancers

1 reference

12 December 2020

Knockdown of Chk1 sensitizes human colon carcinoma HCT116 cells in a p53-dependent manner to lidamycin through abrogation of a G2/M checkpoint and induction of apoptosis.

1 reference

12 December 2020

Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia

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12 December 2020

Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia

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12 December 2020

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2745

1 reference

21 August 2017

1 reference

PubMed ID

19890334