(Q37638137)

21 August 2017

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title

Metabolism and cancer: the circadian clock connection (English)

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21 August 2017

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2

Paolo Sassone-Corsi

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21 August 2017

Saurabh Sahar

1

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21 August 2017

language of work or name

English

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publication date

1 December 2009

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21 August 2017

published in

Nature Reviews Cancer

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21 August 2017

volume

9

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21 August 2017

issue

12

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21 August 2017

page(s)

886-896

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https://scigraph.springernature.com/pub.10.1038/nrc2747

21 August 2017

exact match

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31 March 2020

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31 March 2020

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31 March 2020

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The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response

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The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells

31 March 2020

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The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo

31 March 2020

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Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia

31 March 2020

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Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest

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31 March 2020

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31 March 2020

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31 March 2020

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The mPer2 gene encodes a functional component of the mammalian circadian clock

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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A phylogenetically conserved DNA damage response resets the circadian clock

31 March 2020

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31 March 2020

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A genomewide oscillation in transcription gates DNA replication and cell cycle

31 March 2020

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Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity.

31 March 2020

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31 March 2020

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Adverse metabolic and cardiovascular consequences of circadian misalignment

31 March 2020

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Loss of Nocturnin, a circadian deadenylase, confers resistance to hepatic steatosis and diet-induced obesity

31 March 2020

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Nuclear receptor expression links the circadian clock to metabolism

31 March 2020

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Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

31 March 2020

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Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes

31 March 2020

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Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

31 March 2020

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

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How does SIRT1 affect metabolism, senescence and cancer?

31 March 2020

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

31 March 2020

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Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

31 March 2020

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

31 March 2020

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SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

31 March 2020

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

31 March 2020

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Conserved metabolic regulatory functions of sirtuins

31 March 2020

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

31 March 2020

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

31 March 2020

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Light induces chromatin modification in cells of the mammalian circadian clock.

31 March 2020

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Decoding the epigenetic language of neuronal plasticity

31 March 2020

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Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair

31 March 2020

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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

31 March 2020

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DNA repair deficiency as a therapeutic target in cancer

31 March 2020

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Nampt: linking NAD biology, metabolism and cancer

31 March 2020

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Statins and cancer prevention

31 March 2020

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Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

31 March 2020

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31 March 2020

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A role of the circadian system and circadian proteins in aging.

31 March 2020

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31 March 2020

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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

31 March 2020

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Mop3 is an essential component of the master circadian pacemaker in mammals

31 March 2020

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Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior

31 March 2020

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Positional cloning of the mouse circadian clock gene

31 March 2020

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Role of the CLOCK protein in the mammalian circadian mechanism

31 March 2020

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A clock shock: mouse CLOCK is not required for circadian oscillator function

31 March 2020

1 reference

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

31 March 2020

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

31 March 2020

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BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

31 March 2020

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Physiological significance of a peripheral tissue circadian clock

31 March 2020

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Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2

31 March 2020

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Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.

31 March 2020

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Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

31 March 2020

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Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice

31 March 2020

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Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins

31 March 2020

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Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.

31 March 2020

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Casein kinase 1 delta regulates the pace of the mammalian circadian clock

31 March 2020

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Identification of Rev-erbalpha as a physiological repressor of apoC-III gene transcription

31 March 2020

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Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha

31 March 2020

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Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

31 March 2020

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PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

31 March 2020

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The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice

31 March 2020

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Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states

31 March 2020

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12 December 2020

Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock

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12 December 2020

Circadian gating of S phase in human ovarian cancer.

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12 December 2020

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

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12 December 2020

Circadian rhythm and cell cycle: possible entraining mechanisms

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12 December 2020

The days and nights of cancer cells

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12 December 2020

DNA synthesis and ploidy in non-Hodgkin's lymphomas demonstrate intrapatient variation depending on circadian stage of cell sampling

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12 December 2020

Central and peripheral circadian oscillator mechanisms in flies and mammals.

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12 December 2020

Identifiers

DOI

10.1038/NRC2747

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Dimensions Publication ID

21 August 2017

1003078665

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