(Q37639811)

21 August 2017

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title

Searching for perfect sleep: the continuing evolution of GABAA receptor modulators as hypnotics (English)

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21 August 2017

1

David J Nutt

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author name string

S M Stahl

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

26 November 2009

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Journal of Psychopharmacology

21 August 2017

published in

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21 August 2017

volume

24

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21 August 2017

issue

11

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21 August 2017

page(s)

1601-1612

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Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors

21 August 2017

cites work

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TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

21 January 2018

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A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO(2) models of experimental human anxiety.

21 January 2018

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Residual effects of hypnotics on disengagement of spatial attention.

21 January 2018

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Next-day cognition, psychomotor function, and driving-related skills following nighttime administration of eszopiclone

21 January 2018

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Sedative and anxiolytic effects of zopiclone's enantiomers and metabolite

21 January 2018

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Mechanism of action of the hypnotic zolpidem in vivo

21 January 2018

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An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

21 January 2018

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Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers.

21 January 2018

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Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.

21 January 2018

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Comparative pharmacokinetics and pharmacodynamics of short-acting hypnosedatives: zaleplon, zolpidem and zopiclone

21 January 2018

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Treating insomnia: Current and investigational pharmacological approaches

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881109106927

Sleep Latency Is Shortened During 4 Weeks of Treatment With Zaleplon, a Novel Nonbenzodiazepine Hypnotic

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881109106927

Eszopiclone co-administered with fluoxetine in patients with insomnia coexisting with major depressive disorder

21 January 2018

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Stereoselective distribution and stereoconversion of zopiclone enantiomers in plasma and brain tissues in rats

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881109106927

Affective and cognitive effects of global deletion of alpha3-containing gamma-aminobutyric acid-A receptors

21 January 2018

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Molecular actions of (S)-desmethylzopiclone (SEP-174559), an anxiolytic metabolite of zopiclone

21 January 2018

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Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons

21 January 2018

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https://api.crossref.org/works/10.1177%2F0269881109106927

The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes

21 January 2018

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A bidirectional relationship between anxiety and depression, and insomnia? A prospective study in the general population.

21 January 2018

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Pharmacological and clinical studies of cyclopyrrolones: zopiclone and suriclone

21 January 2018

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Benzodiazepine hypnotics and insomnia

21 January 2018

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Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity.

21 January 2018

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Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihyd

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Molecular and neuronal substrate for the selective attenuation of anxiety.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Effects of flurazepam and zopiclone on the performance of chronic insomniac patients: a study of ethanol-drug interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Comparative effects of nonselective and subtype-selective gamma-aminobutyric acidA receptor positive modulators in the rat-conditioned emotional response test

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

A polysomnography study of eszopiclone in elderly patients with insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Stereoselective discriminative stimulus effects of zopiclone in rhesus monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Zolpidem and rebound insomnia--a double-blind, controlled polysomnographic study in chronic insomniac patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Eszopiclone, a nonbenzodiazepine sedative-hypnotic agent for the treatment of transient and chronic insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Binding and neuropharmacological profile of zaleplon, a novel nonbenzodiazepine sedative/hypnotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

GABA(A) receptors: immunocytochemical distribution of 13 subunits in the adult rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Eszopiclone coadministered with escitalopram in patients with insomnia and comorbid generalized anxiety disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Sleep problems, comorbid mental disorders, and role functioning in the national comorbidity survey replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Efficacy and safety of zolpidem-MR: a double-blind, placebo-controlled study in adults with primary insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

An evaluation of the efficacy and safety of eszopiclone over 12 months in patients with chronic primary insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Analysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABA(A) receptor subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Homeostatic, circadian, and emotional regulation of sleep

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Eszopiclone for the treatment of insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

A 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Structure, pharmacology, and function of GABAA receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Functional domains of GABAA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Next-day residual effects of hypnotics in DSM-IV primary insomnia: a driving simulator study with simultaneous electroencephalogram monitoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Insomnia comorbidity and impact and hypnotic use by age group in a national survey population aged 16 to 74 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Noise-induced sleep maintenance insomnia: hypnotic and residual effects of zaleplon

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

A double-blind comparative study of zolpidem versus zopiclone in the treatment of chronic primary insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Lack of residual sedation following middle-of-the-night zaleplon administration in sleep maintenance insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Efficacy and safety of zolpidem extended release in elderly primary insomnia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

GABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

GABAA receptor pharmacology of fluorinated derivatives of the novel sedative-hypnotic pyrazolopyrimidine indiplon

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Pharmacokinetic profile of a new modified release formulation of zolpidem designed to improve sleep maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

The morbidity of insomnia uncomplicated by psychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

Efficacy and safety of eszopiclone across 6-weeks of treatment for primary insomnia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

P.8.a.026 Pharmacokinetics of (S)-zopiclone and (S)-desmethylzopiclone following dosing with zopiclone and eszopiclone

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0269881109106927

21 January 2018

Identifiers

DOI

10.1177/0269881109106927

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21 August 2017

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