(Q37641556)

21 August 2017

7 references

13 March 2019

19 March 2019

17 June 2019

31 July 2019

2 October 2019

15 December 2019

18 July 2020

Platelet thrombin receptor antagonism and atherothrombosis (English)

1 reference

21 August 2017

7 references

13 March 2019

19 March 2019

17 June 2019

31 July 2019

2 October 2019

15 December 2019

18 July 2020

cell surface receptor

1 reference

31 July 2019

1 reference

2 October 2019

1 reference

15 December 2019

1 reference

18 July 2020

Davide Capodanno

2

0 references

Dominick Angiolillo

series ordinal

1

object named as

Dominick J Angiolillo

1 reference

21 August 2017

Shinya Goto

3

1 reference

21 August 2017

language of work or name

1 reference

30 November 2009

1 reference

21 August 2017

1 January 2010

7 references

13 March 2019

19 March 2019

17 June 2019

31 July 2019

2 October 2019

15 December 2019

18 July 2020

European Heart Journal

8 references

21 August 2017

13 March 2019

19 March 2019

17 June 2019

31 July 2019

2 October 2019

15 December 2019

18 July 2020

31

1 reference

21 August 2017

1

1 reference

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17-28

1 reference

Creative Commons Attribution-NonCommercial

21 August 2017

7 references

13 March 2019

19 March 2019

17 June 2019

31 July 2019

2 October 2019

15 December 2019

18 July 2020

on focus list of Wikimedia project

ScienceSource

0 references

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Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity

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Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis

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Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets

23 August 2017

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Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin

23 August 2017

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23 August 2017

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Effects of aspirin dose when used alone or in combination with clopidogrel in patients with acute coronary syndromes: observations from the Clopidogrel in Unstable angina to prevent Recurrent Events (CURE) study

23 August 2017

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Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage

23 August 2017

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23 August 2017

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Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin

23 August 2017

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Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome

23 August 2017

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PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets

23 August 2017

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Mechanisms of action of proteinase-activated receptor agonists on human platelets

23 August 2017

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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

23 August 2017

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Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies

23 August 2017

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Role of thrombin signalling in platelets in haemostasis and thrombosis

23 August 2017

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Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

23 August 2017

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Impaired activation of murine platelets lacking G alpha(i2)

23 August 2017

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Molecular identification and characterization of the platelet ADP receptor targeted by thienopyridine antithrombotic drugs

23 August 2017

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Protease activated receptors: theme and variations

23 August 2017

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PAR3 is a cofactor for PAR4 activation by thrombin

23 August 2017

1 reference

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Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor

23 August 2017

1 reference

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Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity

23 August 2017

1 reference

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Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

23 August 2017

1 reference

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A dual thrombin receptor system for platelet activation

23 August 2017

1 reference

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Coactivation of two different G protein-coupled receptors is essential for ADP-induced platelet aggregation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Cloning and characterization of human protease-activated receptor 4

23 August 2017

1 reference

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CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

23 August 2017

1 reference

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A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

23 August 2017

1 reference

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Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration

23 August 2017

1 reference

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Molecular cloning of a potential proteinase activated receptor

23 August 2017

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Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study

23 August 2017

1 reference

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A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation

23 August 2017

1 reference

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

23 August 2017

1 reference

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Acetylation of prostaglandin synthase by aspirin

23 August 2017

1 reference

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Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets

23 August 2017

1 reference

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Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin

6 September 2017

1 reference

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Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Integrin signaling: the platelet paradigm

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Vascular actions of thrombin receptor peptide

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Impact of P2Y(12) inhibitory effects induced by clopidogrel on platelet procoagulant activity in type 2 diabetes mellitus patients.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Prasugrel versus clopidogrel in patients with acute coronary syndromes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Platelet adhesion and signaling induced by the octapeptide primary binding sequence (KOGEOGPK) from type III collagen

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Platelets, after exposure to a high shear stress, induce IL-10-producing, mature dendritic cells in vitro

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

The relative importance of the ADP receptors, P2Y12 and P2Y1, in thrombin-induced platelet activation.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Reduced thrombus cohesion in an ex vivo human model of arterial thrombosis induced by clopidogrel treatment: kinetics of the effect and influence of single and double loading-dose regimens

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Platelet ADP receptors contribute to the initiation of intravascular coagulation

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Evidence for a role for Galphai1 in mediating weak agonist-induced platelet aggregation in human platelets: reduced Galphai1 expression and defective Gi signaling in the platelets of a patient with a chronic bleeding disorder

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

Defective platelet activation in G alpha(q)-deficient mice.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2800923

1 September 2018

1 reference

12 December 2020

Molecular mechanism of thromboxane A(2)-induced platelet aggregation. Essential role for p2t(ac) and alpha(2a) receptors

1 reference

12 December 2020

Platelet P2Y12 receptors enhance signalling towards procoagulant activity and thrombin generation. A study with healthy subjects and patients at thrombotic risk

1 reference

12 December 2020

A key role of adenosine diphosphate in the irreversible platelet aggregation induced by the PAR1-activating peptide through the late activation of phosphoinositide 3-kinase

1 reference

12 December 2020

In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist

1 reference

12 December 2020

ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Galphaq

1 reference

12 December 2020

Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage

1 reference

12 December 2020

Cardiovascular biology. Platelets and proteases

1 reference

12 December 2020

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

1 reference

12 December 2020

Thrombin functions during tissue factor-induced blood coagulation

1 reference

12 December 2020

Stimulus-induced release of endogenous catecholamines from human washed platelets

1 reference

12 December 2020

Aspirin and dipyridamole in the prevention of restenosis after percutaneous transluminal coronary angioplasty

1 reference

12 December 2020

An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey

1 reference

12 December 2020

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice

1 reference

12 December 2020

Identifiers

DOI

10.1093/EURHEARTJ/EHP504

1 reference

21 August 2017

1 reference

21 August 2017

PubMed publication ID

19948715

1 reference