(Q37644503)

21 August 2017

1 reference

title

Key role of ERK pathway signaling in lupus (English)

1 reference

21 August 2017

Gabriela Gorelik

1

1 reference

PMCID

2819407

21 August 2017

Bruce Richardson

series ordinal

2

1 reference

21 August 2017

1 February 2010

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21 August 2017

1 reference

21 August 2017

43

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21 August 2017

1

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21 August 2017

17-22

1 reference

Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Metabolic control of T cell activation and death in SLE.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

The role of Ras signaling in lupus T lymphocytes: biology and pathogenesis.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Primer: epigenetics of autoimmunity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

GTPases and T cell activation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

T cell antigen receptor signal transduction pathways

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Regulation of DNA methylation by the Ras signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Procainamide inhibits DNA methyltransferase in a human T cell line

25 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Evidence for protein kinase C-dependent and -independent activation of mitogen-activated protein kinase in T cells: potential role of additional diacylglycerol binding proteins.

25 June 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

Hypomethylation of interleukin-4 and -6 promoters in T cells from systemic lupus erythematosus patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

Hydralazine may induce autoimmunity by inhibiting extracellular signal-regulated kinase pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374832

The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2819407

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

3 December 2018

1 reference

12 December 2020

Control of lymphocyte function through CD27–CD70 interactions

1 reference

12 December 2020

Defective activation of protein kinase C and Ras-ERK pathways limits IL-2 production and proliferation by CD4+CD25+ regulatory T cells

1 reference

12 December 2020

Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus

1 reference

12 December 2020

Decreased Ras-mitogen-activated protein kinase signaling may cause DNA hypomethylation in T lymphocytes from lupus patients

1 reference

12 December 2020

Defective activity of ERK-1 and ERK-2 mitogen-activated protein kinases in peripheral blood T lymphocytes from patients with systemic lupus erythematosus: potential role of altered coupling of Ras guanine nucleotide exchange factor hSos to adapter p

1 reference

12 December 2020

Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes

1 reference

12 December 2020

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity

1 reference

12 December 2020

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation

1 reference

12 December 2020

Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis

1 reference

12 December 2020

Systemic lupus erythematosus

1 reference

12 December 2020

Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity

1 reference

12 December 2020

Role of the ras-MAPK signaling pathway in the DNA methyltransferase response to DNA hypomethylation

1 reference

12 December 2020

10.3109/08916930903374832

Identifiers

DOI

1 reference

21 August 2017

1 reference

21 August 2017

1 reference

PMCID

2819407