(Q37650185)

21 August 2017

1 reference

title

RhoGDI2 as a therapeutic target in cancer (English)

1 reference

21 August 2017

Hee Jun Cho

1

1 reference

21 August 2017

Kyoung Eun Baek

series ordinal

2

1 reference

21 August 2017

Jiyun Yoo

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 January 2010

1 reference

Expert Opinion on Therapeutic Targets

21 August 2017

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21 August 2017

14

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21 August 2017

1

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21 August 2017

67-75

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Metastasis: a therapeutic target for cancer

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho signals to cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GTPases in cancer cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GTPases in cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GTPase expression in tumourigenesis: evidence for a significant link

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GTPases and their effector proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Guanine nucleotide exchange factors for Rho GTPases: turning on the switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GTPase-activating proteins in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

GDIs: central regulatory molecules in Rho GTPase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDI: multiple functions in the regulation of Rho family GTPase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDIs revisited: novel roles in Rho regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GDP dissociation inhibitors as potential targets for anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Structure-activity relationships in flexible protein domains: regulation of rho GTPases by RhoGDI and D4 GDI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

The guanine nucleotide-binding switch in three dimensions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Dissociation of GDP dissociation inhibitor and membrane translocation are required for efficient activation of Rac by the Dbl homology-pleckstrin homology region of Tiam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Loss of expression of LyGDI (ARHGDIB), a rho GDP-dissociation inhibitor, in Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

The relationship of BRMS1 and RhoGDI2 gene expression to metastatic potential in lineage related human bladder cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDI2 is an invasion and metastasis suppressor gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Neuromedin U is regulated by the metastasis suppressor RhoGDI2 and is a novel promoter of tumor formation, lung metastasis and cancer cachexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Changes in gene expression during progression of ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Silencing of D4-GDI inhibits growth and invasive behavior in MDA-MB-231 cells by activation of Rac-dependent p38 and JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

The biology of the Ets1 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

ETS transcription factors and their emerging roles in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Role of integrins in cell invasion and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Inhibition of cyclooxygenase-2 decreases breast cancer cell motility, invasion and matrix metalloproteinase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDI2 expression is associated with tumor growth and malignant progression of gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

ZAK negatively regulates RhoGDIbeta-induced Rac1-mediated hypertrophic growth and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RhoGDIbeta-induced hypertrophic growth in H9c2 cells is negatively regulated by ZAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rac signaling in tumorigenesis and as target for anticancer drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

RNAi-mediated gene silencing in non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

Phosphoinositide-dependent activation of Rho A involves partial opening of the RhoA/Rho-GDI complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903449251

10.1517/14728220903449251

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference