(Q37650487)

English

Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases

scientific article published on February 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

1 reference

Europe PubMed Central

Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

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author name string

Debjani Ghosh

1

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

George C Tsokos

2

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

publication date

1 February 2010

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

43

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

48-55

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

Structure and function of Syk protein-tyrosine kinase

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Identification of the phosphorylation sites of H2B histone by a catalytic fragment of p72sykfrom porcine spleen

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Signaling network of the Btk family kinases

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

The structure, regulation, and function of ZAP-70.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Functional dissection of BCR signaling pathways

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Early events of B cell activation by antigen.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

T cell receptor-mediated signs and signals governing T cell development

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

T cell antigen-receptor signal transduction

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Systematic identification of regulatory proteins critical for T-cell activation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Syk tyrosine kinase required for mouse viability and B-cell development

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Protein tyrosine kinases in thymocyte development

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

The development of allergic inflammation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

The tyrosine kinase network regulating mast cell activation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Protein tyrosine kinase Syk in mast cell signaling

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Protein-tyrosine phosphorylation: an essential component of Fc epsilon RI signaling.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Monosodium urate monohydrate crystals induce the release of the proinflammatory protein S100A8/A9 from neutrophils

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Kinase inhibitors for the treatment of inflammatory and autoimmune disorders

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Syk inhibitors as treatment for allergic rhinitis

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Potent small molecule inhibitors of spleen tyrosine kinase (Syk).

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Identification of the Syk kinase inhibitor R112 by a human mast cell screen

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Development of a high-throughput fluoroimmunoassay for Syk kinase and Syk kinase inhibitors

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

The 1982 revised criteria for the classification of systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Altered signal transduction in SLE T cells

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Cholera toxin B accelerates disease progression in lupus-prone mice by promoting lipid raft aggregation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374717

21 January 2018

Identifiers

10.3109/08916930903374717

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 August 2017

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