(Q37662544)

English

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts

scientific article published on April 1996

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scholarly article

1 reference

Europe PubMed Central

21 August 2017

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts (English)

1 reference

Europe PubMed Central

21 August 2017

1 reference

based on heuristic

inferred from title

author name string

W Lewis

1

1 reference

Europe PubMed Central

21 August 2017

E S Levine

2

1 reference

Europe PubMed Central

21 August 2017

B Griniuviene

3

1 reference

Europe PubMed Central

21 August 2017

K O Tankersley

4

1 reference

Europe PubMed Central

21 August 2017

J M Colacino

5

1 reference

Europe PubMed Central

21 August 2017

J P Sommadossi

6

1 reference

Europe PubMed Central

21 August 2017

K A Watanabe

7

1 reference

Europe PubMed Central

21 August 2017

F W Perrino

8

1 reference

Europe PubMed Central

21 August 2017

language of work or name

0 references

publication date

1 April 1996

1 reference

Europe PubMed Central

21 August 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

1 reference

Europe PubMed Central

21 August 2017

93

1 reference

Europe PubMed Central

21 August 2017

3592-3597

1 reference

Europe PubMed Central

21 August 2017

8

1 reference

Europe PubMed Central

21 August 2017

Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Sequence and organization of the human mitochondrial genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

A low-viscosity epoxy resin embedding medium for electron microscopy

1 reference

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23 August 2017

Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Inhibition of human immunodeficiency virus 1 reverse transcriptase by 3'-azidothymidine triphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Fluorinated pyrimidines: a new change for old drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Use of a standardized cell culture assay to assess activities of nucleoside analogs against hepatitis B virus replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

A general method for isolation of high molecular weight DNA from eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

23 August 2017

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

6 September 2017

Incorporation of cytosine arabinoside monophosphate into DNA at internucleotide linkages by human DNA polymerase alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

6 September 2017

Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

14 September 2017

Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

14 September 2017

Mitochondrial toxicity of antiviral drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

14 September 2017

The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

Zidovudine causes early increases in mitochondrial ribonucleic acid abundance and induces ultrastructural changes in cultured mouse muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

The 5'-triphosphates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

Development and application of an in vitro model for screening anti-hepatitis B virus therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=39655

25 June 2018

Pharmacological disposition and metabolic fate of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in mice and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of metabolites of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine into deoxyribonucleic acid of neoplastic and normal mammalian tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential extension of 3' mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Actin isoform mRNA alterations induced by doxorubicin in cultured heart cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deaths in US fialuridine trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatitis study. Drug trial deaths deemed unavoidable

1 reference

https://pubmed.ncbi.nlm.nih.gov/8622980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.93.8.3592

1 reference

Europe PubMed Central

21 August 2017

1996PNAS...93.3592L

0 references

1 reference

Europe PubMed Central

21 August 2017

1 reference

Europe PubMed Central

21 August 2017

ResearchGate publication ID

0 references

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