(Q37670256)

21 August 2017

1 reference

title

Dickkopf-1 as a potential therapeutic target in Paget's disease of bone (English)

1 reference

21 August 2017

Helen S McCarthy

1

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author name string

Michael J Marshall

series ordinal

2

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PubMed ID

20055719

21 August 2017

language of work or name

English

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publication date

1 February 2010

1 reference

Expert Opinion on Therapeutic Targets

21 August 2017

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21 August 2017

14

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21 August 2017

2

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21 August 2017

221-230

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Incidence and natural history of Paget's disease of bone in England and Wales.

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Genetics and aetiology of Pagetic disorders of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Sarcoma arising in Paget's disease of bone: declining incidence and increasing age at presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Chondrosarcoma as a complicating factor in Paget's disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Minireview: the OPG/RANKL/RANK system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Role of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in bone cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Wnt signaling in osteoblasts and bone diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

High bone density due to a mutation in LDL-receptor-related protein 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The role of Wnts in bone metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Cross-talk between Wnt and bone morphogenetic protein 2 (BMP-2) signaling in differentiation pathway of C2C12 myoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Vital elements of the Wnt-Frizzled signaling pathway in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Wnt7a interaction with Fzd5 and detection of signaling activation using a split eGFP

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

An LDL-receptor-related protein mediates Wnt signalling in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Wnt signaling, Ca2+, and cyclic GMP: visualizing Frizzled functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Secreted antagonists of the Wnt signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Secreted frizzled related protein (sFRP)-2 inhibits bone formation and promotes cell proliferation in ameloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Comprehensive expression analysis of all Wnt genes and their major secreted antagonists during mouse limb development and cartilage differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

A new secreted protein that binds to Wnt proteins and inhibits their activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Bone mass is inversely proportional to Dkk1 levels in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Downregulation of Wnt signaling by increased expression of Dickkopf-1 and -2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Sclerostin promotes the apoptosis of human osteoblastic cells: a novel regulation of bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Radiography of successful bone marrow transplantation for osteopetrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Atypical multinucleated cells form in long-term marrow cultures from patients with Paget's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Paramyxovirus-like nuclear inclusions identical to those of Paget's disease of bone detected in giant cells of primary oxalosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The ubiquitin protein catabolic disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Expression of measles virus nucleocapsid protein in osteoclasts induces Paget's disease-like bone lesions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Identification of SQSTM1 mutations in familial Paget's disease in Australian pedigrees

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Three Novel Mutations in SQSTM1 Identified in Familial Paget's Disease of Bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Increased circulating Dickkopf-1 in Paget's disease of bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The effect of zoledronic acid on serum dickkopf-1, osteoprotegerin, and RANKL in patients with Paget's disease of bone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Serum proinflammatory mediators at different periods of therapy in patients with multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Metastatic breast cancer induces an osteoblast inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Serum interleukin-6 in patients with metastatic bone disease: correlation with cystatin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Essential role of beta-catenin in postnatal bone acquisition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Osteoclasts are active in bone forming metastases of prostate cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Novel aspects of osteoclast activation and osteoblast inhibition in myeloma bone disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Molecular mechanisms of action of bisphosphonates: current status.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Biochemical and radiologic improvement in Paget's disease of bone treated with alendronate: A randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-?B ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

Loss of Ubiquitin Binding Is a Unifying Mechanism by Which Mutations of SQSTM1 Cause Paget’s Disease of Bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903525720

10.1517/14728220903525720

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20055719