(Q37679296)

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Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury

scientific article published on April 2014

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21 August 2017

Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury (English)

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21 August 2017

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Bernard L. Schneider

8

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12 June 2020

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12 June 2020

Athanasios Didangelos

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12 June 2020

Rafael J Yáñez-Muñoz

6

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12 June 2020

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12 June 2020

Elizabeth J. Bradbury

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12 June 2020

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Nicholas D James

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12 June 2020

Karen D Bosch

4

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12 June 2020

Joost Verhaagen

5

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12 June 2020

Elizabeth M Muir

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12 June 2020

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1 April 2014

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21 August 2017

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Journal of Neuroscience

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12 June 2020

34

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12 June 2020

14

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12 June 2020

4822-4836

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12 June 2020

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11 June 2022

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High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury

1 reference

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1 reference

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Viral vector-mediated selective and reversible blockade of the pathway for visual orienting in mice

1 reference

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23 August 2017

Chondroitin sulfate proteoglycans potently inhibit invasion and serve as a central organizer of the brain tumor microenvironment.

1 reference

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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

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23 August 2017

Nerve regeneration restores supraspinal control of bladder function after complete spinal cord injury.

1 reference

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23 August 2017

Chondroitinase ABC promotes compensatory sprouting of the intact corticospinal tract and recovery of forelimb function following unilateral pyramidotomy in adult mice

1 reference

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23 August 2017

Conditional Sox9 ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury

1 reference

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23 August 2017

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury

1 reference

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23 August 2017

A sulfated carbohydrate epitope inhibits axon regeneration after injury.

1 reference

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23 August 2017

Macrophage plasticity and polarization: in vivo veritas

1 reference

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23 August 2017

Chondroitinase ABC promotes selective reactivation of somatosensory cortex in squirrel monkeys after a cervical dorsal column lesion

1 reference

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23 August 2017

Conduction failure following spinal cord injury: functional and anatomical changes from acute to chronic stages

1 reference

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23 August 2017

Functional regeneration of respiratory pathways after spinal cord injury

1 reference

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23 August 2017

Chondroitinase activity can be transduced by a lentiviral vector in vitro and in vivo.

1 reference

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23 August 2017

Extracellular matrix composition and remodeling in human abdominal aortic aneurysms: a proteomics approach

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23 August 2017

Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection

1 reference

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23 August 2017

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury

1 reference

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23 August 2017

Chondroitinase ABC enhances pericontusion axonal sprouting but does not confer robust improvements in behavioral recovery

1 reference

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23 August 2017

Injured mice at the gym: review, results and considerations for combining chondroitinase and locomotor exercise to enhance recovery after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972714

23 August 2017

Role of chondroitin sulfate proteoglycans in axonal conduction in Mammalian spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972714

23 August 2017

Combining peripheral nerve grafts and chondroitinase promotes functional axonal regeneration in the chronically injured spinal cord.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972714

23 August 2017

Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972714

23 August 2017

Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972714

23 August 2017

Administration of chondroitinase ABC rostral or caudal to a spinal cord injury site promotes anatomical but not functional plasticity.

1 reference

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23 August 2017

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23 August 2017

The yellow fluorescent protein (YFP-H) mouse reveals neuroprotection as a novel mechanism underlying chondroitinase ABC-mediated repair after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972714

23 August 2017

Chondroitinase ABC-mediated plasticity of spinal sensory function

1 reference

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23 August 2017

Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans

1 reference

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23 August 2017

Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression

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23 August 2017

Spinal cord repair strategies: why do they work?

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23 August 2017

Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury

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23 August 2017

Chondroitin sulfate proteoglycans in neural development and regeneration.

1 reference

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23 August 2017

Regeneration beyond the glial scar

1 reference

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23 August 2017

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23 August 2017

Chondroitinase ABC promotes functional recovery after spinal cord injury

1 reference

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23 August 2017

Exogenous glycosaminoglycans induce complete inversion of retinal ganglion cell bodies and their axons within the retinal neuroepithelium

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6 September 2017

Chondroitin sulfate: a key molecule in the brain matrix.

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6 September 2017

Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity.

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6 September 2017

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6 September 2017

Mammalian-produced chondroitinase AC mitigates axon inhibition by chondroitin sulfate proteoglycans

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6 September 2017

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

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Modification of N-glycosylation sites allows secretion of bacterial chondroitinase ABC from mammalian cells

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25 June 2018

Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury.

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25 June 2018

A sulfated disaccharide derived from chondroitin sulfate proteoglycan protects against inflammation-associated neurodegeneration

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25 June 2018

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1 September 2018

Chondroitinase treatment following spinal contusion injury increases migration of oligodendrocyte progenitor cells

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1 September 2018

Single, high-dose intraspinal injection of chondroitinase reduces glycosaminoglycans in injured spinal cord and promotes corticospinal axonal regrowth after hemisection but not contusion

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1 September 2018

Chondroitin sulfate proteoglycans in spinal cord contusion injury and the effects of chondroitinase treatment.

1 reference

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1 September 2018

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Axonal Regeneration through Regions of Chondroitin Sulfate Proteoglycan Deposition after Spinal Cord Injury: A Balance of Permissiveness and Inhibition

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The recovery of 5-HT immunoreactivity in lumbosacral spinal cord and locomotor function after thoracic hemisection

1 reference

https://pubmed.ncbi.nlm.nih.gov/24695702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/24695702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/24695702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/24695702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4369-13.2014

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24695702%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24695702%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24695702%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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