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Rapamycin: one drug, many effects
scientific article published on 06 February 2014
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
title
Rapamycin: one drug, many effects
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
main subject
sirolimus
1 reference
based on heuristic
inferred from title
author name string
Jing Li
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
Sang Gyun Kim
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
John Blenis
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
publication date
6 February 2014
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
published in
Cell Metabolism
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
volume
19
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stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
issue
3
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stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
page(s)
373-379
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stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
cites work
mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin extends life- and health span because it slows aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin extends murine lifespan but has limited effects on aging
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Duration of rapamycin treatment has differential effects on metabolism in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapalogs and mTOR inhibitors as anti-aging therapeutics
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
mTOR is a key modulator of ageing and age-related disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin slows aging in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
mTOR signaling in growth control and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
mTOR inhibitors in cancer therapy.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Target of rapamycin (TOR) in nutrient signaling and growth control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Fighting neurodegeneration with rapamycin: mechanistic insights
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Transcriptional control of cellular metabolism by mTOR signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Efficacy and safety of sirolimus in lymphangioleiomyomatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Common corruption of the mTOR signaling network in human tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Molecular mechanisms of mTOR-mediated translational control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin reduces seizure frequency in tuberous sclerosis complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin treatment for a child with germline PTEN mutation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
23 August 2017
mTOR in aging, metabolism, and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
6 September 2017
Rapamycin passes the torch: a new generation of mTOR inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
6 September 2017
eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
6 September 2017
Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
14 September 2017
Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
28 September 2017
Rapamycin inhibits human adipocyte differentiation in primary culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
28 September 2017
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
25 June 2018
Long-term administration of rapamycin reduces adiposity, but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
1 September 2018
Rapamycin inhibits mTORC1, but not completely.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
1 September 2018
Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
1 September 2018
mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3972801
retrieved
1 September 2018
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24508508
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24508508
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CMET.2014.01.001
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
PMCID
3972801
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
PubMed ID
24508508
1 reference
stated in
Europe PubMed Central
PMCID
3972801
retrieved
21 August 2017
ResearchGate publication ID
260129914
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