(Q37684283)

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Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).

scientific article published on 29 January 2010

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Europe PubMed Central

22 August 2017

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Europe PubMed Central

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Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS). (English)

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Europe PubMed Central

22 August 2017

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James P Allison

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Sergio A Quezada

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Sergio A Quezada

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Tyler R Simpson

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Europe PubMed Central

22 August 2017

29 January 2010

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Europe PubMed Central

22 August 2017

Current Opinion in Immunology

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Europe PubMed Central

22 August 2017

22

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Europe PubMed Central

22 August 2017

326-332

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Europe PubMed Central

22 August 2017

3

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Europe PubMed Central

22 August 2017

ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS is critical for CD40-mediated antibody class switching

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Transcriptional regulation of th2 differentiation by inducible costimulator.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

B7h is required for T cell activation, differentiation, and effector function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

CD28 controls differentiation of regulatory T cells from naive CD4 T cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

CD28 and inducible costimulatory protein Src homology 2 binding domains show distinct regulation of phosphatidylinositol 3-kinase, Bcl-xL, and IL-2 expression in primary human CD4 T lymphocytes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS co-stimulatory receptor is essential for T-cell activation and function

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

T-cell co-stimulation through B7RP-1 and ICOS

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS deficiency results in exacerbated IL-17 mediated experimental autoimmune encephalomyelitis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Human ICOS deficiency abrogates the germinal center reaction and provides a monogenic model for common variable immunodeficiency.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS controls the pool size of effector-memory and regulatory T cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The ICOS molecule plays a crucial role in the development of mucosal tolerance

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Phosphoinositide 3-kinase and its targets in B-cell and T-cell signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

T helper cell-specific regulation of inducible costimulator expression via distinct mechanisms mediated by T-bet and GATA-3

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

CTLA-4 blockade increases IFNgamma-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

IL-21 and T follicular helper cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

ICOS is essential for effective T-helper-cell responses

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-gamma levels in both nonmalignant and malignant prostate tissues

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Mechanisms of costimulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Follicular helper T cells are required for systemic autoimmunity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

A costimulation-initiated signaling pathway regulates NFATc1 transcription in T lymphocytes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

Mechanisms of H4/ICOS costimulation: effects on proximal TCR signals and MAP kinase pathways.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.COI.2010.01.001

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10.1016/J.COI.2010.01.001

1 reference

stated in

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

PubMed ID

20116985

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22 August 2017

(Q37684283)

Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).

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