(Q37688050)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

1 reference

title

Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

William G. Newman

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Jenny E Higgs

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Chris Roberts

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

publication date

1 February 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

177-188

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations

17 January 2020

cites work

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

21 January 2018

1 reference

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Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Azathioprine-induced severe pancytopenia due to a homozygous two-point mutation of the thiopurine methyltransferase gene in a patient with juvenile HLA-B27-associated spondylarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Erythrocyte thiopurine methyl transferase assessment prior to azathioprine use in the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.155

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus

21 January 2018

1 reference

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Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

21 January 2018

1 reference

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Guidelines for the management of inflammatory bowel disease in adults

21 January 2018

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Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties

21 January 2018

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Methodological quality of pharmacogenetic studies: issues of concern

21 January 2018

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Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events.

21 January 2018

1 reference

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What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data

21 January 2018

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Undue reliance on I(2) in assessing heterogeneity may mislead

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine

21 January 2018

1 reference

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Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients.

21 January 2018

1 reference

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Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel disease: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

6-thioguanine--efficacy and safety in chronic active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Identification of thiopurine methyltransferase (TPMT) polymorphisms cannot predict myelosuppression in systemic lupus erythematosus patients taking azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

TPMT genotype and its clinical implication in renal transplant recipients with azathioprine treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine methyltransferase (TPMT) heterozygosity and enzyme activity as predictive tests for the development of azathioprine-related adverse events.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Adverse events leading to modification of therapy in a large cohort of patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Is thiopurine methyltransferase genetic polymorphism a major factor for withdrawal of azathioprine in rheumatoid arthritis patients?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine S-methyltransferase gene polymorphism is predictive of azathioprine-induced myelosuppression in heart transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine S-methyltransferase gene (TMPT) polymorphisms in a Mexican population of healthy individuals and leukemic patients.

21 January 2018

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https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine S-methyltransferase gene polymorphism in Japanese patients with autoimmune liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Correlation of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentration in Han Chinese patients treated with azathioprine 25 to 100 mg: A 1-year, single-center, prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

TPMT genotype and the use of thiopurines in paediatric inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Azathioprine metabolite measurements in the treatment of autoimmune hepatitis in pediatric patients: a preliminary report

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Measurement of thiopurine methyltransferase activity and azathioprine metabolites in patients with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Should azathioprine and 5-aminosalicylates be coprescribed in inflammatory bowel disease?: an audit of adverse events and outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine methyltransferase genotype and phenotype status in Japanese patients with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Review article: monitoring of immunomodulators in inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy: results from a large Swedish patient population

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

The case of the misleading funnel plot

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Removing barriers to a clinical pharmacogenetics service

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Azathioprine toxicity and thiopurine methyltransferase genotype in renal transplant patients

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FPGS.09.155

21 January 2018

Identifiers

DOI

10.2217/PGS.09.155

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20136357%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference