(Q37691144)

English

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans

scientific article published on 06 January 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans (English)

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Caenorhabditis elegans

0 references

neurodegeneration

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Annette O Estevez

object named as

Annette O Estevez

1

0 references

Nathaniel J. Szewczyk

object named as

Nathaniel J Szewczyk

3

0 references

object named as

David Gems

4

0 references

author name string

Kathleen L Morgan

2

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Miguel Estevez

5

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

publication date

6 January 2014

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

NeuroToxicology

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

41

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

28-43

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Deletion of thioredoxin reductase and effects of selenite and selenate toxicity in Caenorhabditis elegans

1 reference

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Exposure to environmental toxicants and pathogenesis of amyotrophic lateral sclerosis: state of the art and research perspectives

1 reference

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Mitochondria and FOXO3: breath or die

1 reference

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23 August 2017

Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.

1 reference

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23 August 2017

SOD2 in mitochondrial dysfunction and neurodegeneration

1 reference

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A cytoprotective perspective on longevity regulation

1 reference

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23 August 2017

Selenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?

1 reference

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23 August 2017

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

1 reference

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23 August 2017

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.

1 reference

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23 August 2017

Diapause formation and downregulation of insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss

1 reference

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23 August 2017

Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity

1 reference

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23 August 2017

Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans

1 reference

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23 August 2017

TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans

1 reference

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23 August 2017

Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans

1 reference

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23 August 2017

Role of forkhead transcription factors in diabetes-induced oxidative stress

1 reference

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23 August 2017

Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans

1 reference

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23 August 2017

Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes

1 reference

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23 August 2017

A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

1 reference

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23 August 2017

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

1 reference

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23 August 2017

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

1 reference

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23 August 2017

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2

1 reference

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23 August 2017

The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans

1 reference

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23 August 2017

Selenoproteins and the aging brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Reactive oxygen species enhance insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Regulation of superoxide dismutase genes: implications in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation

1 reference

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23 August 2017

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans

1 reference

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23 August 2017

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

1 reference

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23 August 2017

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

1 reference

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23 August 2017

"Sly as a FOXO": new paths with Forkhead signaling in the brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Whole-genome analysis of sporadic amyotrophic lateral sclerosis

1 reference

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23 August 2017

Caenorhabditis elegans SDF-9 enhances insulin/insulin-like signaling through interaction with DAF-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Dynamic FoxO transcription factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs

1 reference

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23 August 2017

FoxO proteins in insulin action and metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans

1 reference

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23 August 2017

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

1 reference

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23 August 2017

Hereditary early-onset Parkinson's disease caused by mutations in PINK1

1 reference

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23 August 2017

Role of superoxide dismutases in oxidative damage and neurodegenerative disorders

1 reference

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23 August 2017

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

1 reference

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23 August 2017

Oxidative stress and life span determination in the nematode Caenorhabditis elegans

1 reference

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23 August 2017

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

1 reference

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23 August 2017

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

1 reference

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23 August 2017

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

1 reference

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23 August 2017

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

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23 August 2017

Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans.

1 reference

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23 August 2017

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1 reference

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23 August 2017

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

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23 August 2017

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

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23 August 2017

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

23 August 2017

Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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23 August 2017

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

1 reference

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23 August 2017

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1 reference

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23 August 2017

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

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23 August 2017

Interacting genes in nematode dauer larva formation

1 reference

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23 August 2017

A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process

1 reference

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23 August 2017

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences

1 reference

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23 August 2017

Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism.

1 reference

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6 September 2017

Epidemiology of selenium and type 2 diabetes: can we make sense of it?

1 reference

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6 September 2017

FOXOs: signalling integrators for homeostasis maintenance

1 reference

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6 September 2017

ROS in aging Caenorhabditis elegans: damage or signaling?

1 reference

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6 September 2017

Selenium compounds, apoptosis and other types of cell death: an overview for cancer therapy

1 reference

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6 September 2017

PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K/AKT pathway

1 reference

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6 September 2017

Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: the selenium paradox (Review).

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6 September 2017

Possible involvement of overexposure to environmental selenium in the etiology of amyotrophic lateral sclerosis: a short review

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6 September 2017

Selenium in human health and disease

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6 September 2017

Oxidative stress alters the regulatory control of p66Shc and Akt in PINK1 deficient cells.

1 reference

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14 September 2017

A cadmium toxicity assay using stress responsive Caenorhabditis elegans mutant strains

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14 September 2017

Protection against paraquat and A53T alpha-synuclein toxicity by cabergoline is partially mediated by dopamine receptors

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14 September 2017

Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor

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14 September 2017

Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells

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14 September 2017

Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.

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14 September 2017

Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases

1 reference

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23 June 2018

Progression of neurodegeneration and morphologic changes in the brains of juvenile mice with selenoprotein P deleted

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23 June 2018

Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles

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23 June 2018

Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.

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23 June 2018

An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans

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23 June 2018

Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans

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23 June 2018

High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity

1 reference

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1 September 2018

Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of β-catenin survival axis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Further insight into the impact of sodium selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Two fatal cases of selenium toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Comparative toxicosis of sodium selenite and selenomethionine in lambs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Selenocysteine-containing thioredoxin reductase in C. elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3979119

1 September 2018

Comparative toxicity of selenium from seleno-DL-methionine, sodium selenate, and Astragalus bisulcatus in pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical periods in the development of the Caenorhabditis elegans dauer larva

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicokinetics and pathology of plant-associated acute selenium toxicosis in steers

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redox regulation, gene expression and longevity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic defects in acetylcholine signalling promote protein degradation in muscle cells of Caenorhabditis elegans

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cu/Zn superoxide dismutase (SOD1) mutations and sporadic amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24406377

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.NEURO.2013.12.012

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

ResearchGate publication ID

0 references

Sitelinks

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