(Q37692824)

22 August 2017

1 reference

title

Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management (English)

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22 August 2017

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1 reference

4

Yvo B Roos

1 reference

22 August 2017

Nyika D Kruyt

1

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22 August 2017

Geert Jan Biessels

series ordinal

2

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22 August 2017

J Hans Devries

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

16 February 2010

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22 August 2017

published in

Nature Reviews Neurology

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22 August 2017

volume

6

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22 August 2017

issue

3

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22 August 2017

page(s)

145-155

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2009.231

22 August 2017

exact match

0 references

cites work

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Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial

21 January 2018

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Regional cerebral blood flow decreases during chronic and acute hyperglycemia

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Effect of plasma glucose on infarct size in focal cerebral ischemia-reperfusion

21 January 2018

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Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

21 January 2018

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Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site

21 January 2018

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Effects of glucose and PaO2 modulation on cortical intracellular acidosis, NADH redox state, and infarction in the ischemic penumbra

21 January 2018

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Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke

21 January 2018

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Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data

21 January 2018

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How does blood glucose control with insulin save lives in intensive care?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Insulin therapy protects the central and peripheral nervous system of intensive care patients

21 January 2018

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An electronic protocol for translation of research results to clinical practice: a preliminary report

21 January 2018

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Normoglycemia (not hypoglycemia) optimizes outcome from middle cerebral artery occlusion

21 January 2018

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Frequency and temporal profile of poststroke hyperglycemia using continuous glucose monitoring

21 January 2018

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Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome.

31 March 2020

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Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview

31 March 2020

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Blood glucose increases early after stroke onset: a study on serial measurements of blood glucose in acute stroke

31 March 2020

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Poststroke hyperglycemia: natural history and immediate management

31 March 2020

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Reactive hyperglycaemia in patients with acute stroke

31 March 2020

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Transient hyperglycemia in ischemic stroke patients

31 March 2020

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Natural history of blood glucose within the first 48 hours after ischemic stroke

31 March 2020

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Hyperglycemia in patients with focal cerebral ischemia after intravenous thrombolysis: influence on clinical outcome and infarct size

31 March 2020

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Blood glucose, glycosylated haemoglobin, and outcome of ischemic brain infarction

31 March 2020

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Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study.

31 March 2020

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Influence of hyperglycaemia on infarct size and clinical outcome of acute ischemic stroke patients with intracranial arterial occlusion

31 March 2020

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Continuous insulin infusion reduces mortality in patients with diabetes undergoing coronary artery bypass grafting

31 March 2020

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Effect of an intensive glucose management protocol on the mortality of critically ill adult patients

31 March 2020

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Effective glycemic control with aggressive hyperglycemia management is associated with improved outcome in aneurysmal subarachnoid hemorrhage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Tight glycemic control in diabetic coronary artery bypass graft patients improves perioperative outcomes and decreases recurrent ischemic events.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Intensive insulin therapy in critically ill patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Intensive insulin therapy in the medical ICU.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Intensive insulin therapy and pentastarch resuscitation in severe sepsis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Intensive versus conventional glucose control in critically ill patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK).

31 March 2020

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Dynamic of hyperglycemia as a predictor of stroke outcome in the ECASS-II trial

31 March 2020

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Prevalence and prediction of unrecognised diabetes mellitus and impaired glucose tolerance following acute stroke

31 March 2020

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Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke

31 March 2020

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Disorders of glucose metabolism in acute stroke patients: an underrecognized problem

31 March 2020

1 reference

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Impaired glucose metabolism in patients with acute stroke and no previous diagnosis of diabetes mellitus

31 March 2020

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Pituitary function during severe and life-threatening illnesses.

31 March 2020

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Endocrine aspects of acute and prolonged critical illness

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Novel insights into the neuroendocrinology of critical illness

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Glucose metabolism and catecholamines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Relationship between stress, inflammation and metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia in the critically ill patient

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Insular cortical ischemia is independently associated with acute stress hyperglycemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Lateralization in autonomic dysfunction in ischemic stroke involving the insular cortex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Proinflammatory cytokines and early neurological worsening in ischemic stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

The prognostic value of capillary glucose levels in acute stroke: the GLycemia in Acute Stroke (GLIAS) study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Stroke in diabetic and non-diabetic patients: course and prognostic value of admission serum glucose

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia as an independent predictor of worse outcome in non-diabetic patients presenting with acute ischemic stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

31 March 2020

Stress hyperglycaemia

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Blood glucose concentration and outcome of critical illness: the impact of diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia and cognitive outcome after ischemic stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia and early reperfusion therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Predictors of hyperacute clinical worsening in ischemic stroke patients receiving thrombolytic therapy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Lack of improvement in patients with acute stroke after treatment with thrombolytic therapy: predictors and association with outcome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Evolving paradigms in neuroimaging of the ischemic penumbra.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Factor VIIa and tissue factor procoagulant activity in diabetes mellitus after acute ischemic stroke: impact of hyperglycemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Acute hyperglycemia state is associated with lower tPA-induced recanalization rates in stroke patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Perfusion deficit parallels exacerbation of cerebral ischemia/reperfusion injury in hyperglycemic rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

The effects of hyperglycaemia on changes during reperfusion following focal cerebral ischaemia in the cat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Inhibition of protein kinase Cbeta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Effects of simulated hyperglycemia, insulin, and glucagon on endothelial nitric oxide synthase expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Arteriolar nitric oxide concentration is decreased during hyperglycemia-induced betaII PKC activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia promotes elevated generation of TXA2 in isolated rat uteri

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia increased the responsiveness of isolated rabbit's pulmonary arterial rings to serotonin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Oxygen-derived free radicals in postischemic tissue injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hydroxyl radical formation in hyperglycemic rats during middle cerebral artery occlusion/reperfusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Increased oxidative stress during hyperglycemic cerebral ischemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Increased oxidative protein and DNA damage but decreased stress response in the aged brain following experimental stroke.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Biochemistry and molecular cell biology of diabetic complications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia in acute ischemic stroke: a vascular perspective.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia, insulin, and acute ischemic stroke: a mechanistic justification for a trial of insulin infusion therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Lactate: the ultimate cerebral oxidative energy substrate?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Extra- and Intracellular pH in the Brain During Ischaemia, Related to Tissue Lactate Content in Normo- and Hypercapnic rats.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Increased blood-brain barrier permeability and altered tight junctions in experimental diabetes in the rat: contribution of hyperglycaemia and matrix metalloproteinases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Low-dose glucose-insulin-potassium is ineffective in acute myocardial infarction: results of a randomized multicenter Pol-GIK trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiológicos Latinoamérica) Collaborative Group

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial

31 March 2020

1 reference

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The Hyperglycemia: Intensive Insulin Infusion in Infarction (HI-5) study: a randomized controlled trial of insulin infusion therapy for myocardial infarction.

31 March 2020

1 reference

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Intensive Insulin Therapy in Mixed Medical/Surgical Intensive Care Units: Benefit Versus Harm

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

High mean fasting glucose levels independently predict poor outcome and delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia and clinical outcome in aneurysmal subarachnoid hemorrhage: a meta-analysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Variability in physician care practices for glucose treatment in stroke patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Sliding scale insulin--time to stop sliding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Sliding scale insulin use: myth or insanity?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Hyperglycemia management in the hospital setting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Clinical practice. Management of hyperglycemia in the hospital setting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Subjecting acute ischemic stroke patients to continuous tube feeding and an intensive computerized protocol establishes tight glycemic control.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Use of a computerized guideline for glucose regulation in the intensive care unit improved both guideline adherence and glucose regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Computer-assisted glucose control in critically ill patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Efficacy and safety of two 5 day insulin dosing regimens to achieve strict glycaemic control in patients with acute ischaemic stroke.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Identification of nonischemic stroke mimics among 411 code strokes at the University of California, San Diego, Stroke Center

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Optimal blood glucose levels while using insulin to minimize the size of infarction in focal cerebral ischemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

A randomised, controlled pilot study to investigate the potential benefit of intervention with insulin in hyperglycaemic acute ischaemic stroke patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Glucose Regulation in Acute Stroke Patients (GRASP) trial: a randomized pilot trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Pragmatic management of hyperglycaemia in acute ischaemic stroke: safety and feasibility of intensive intravenous insulin treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2009.231

Acidosis and ischemic brain damage.

31 March 2020

1 reference

12 December 2020

Decreased mortality by normalizing blood glucose after acute ischemic stroke

1 reference

12 December 2020

Hyperglycemia induces progressive changes in the cerebral microvasculature and blood-brain barrier transport during focal cerebral ischemia

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12 December 2020

TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells

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12 December 2020

Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the A

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12 December 2020

Treatment of hyperglycemia in ischemic stroke (THIS): a randomized pilot trial

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12 December 2020

Effects of admission hyperglycemia on stroke outcome in reperfused tissue plasminogen activator--treated patients

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12 December 2020

Prognostic Value of the Stress Response Following Stroke

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12 December 2020

Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand

1 reference

12 December 2020

Glycemic control and sliding scale insulin use in medical inpatients with diabetes mellitus

1 reference

12 December 2020

Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes

1 reference

12 December 2020

Prolonged hyperglycemia in the early subacute period after cerebral infarction: effects on short term prognosis.

1 reference

12 December 2020

10.1038/NRNEUROL.2009.231

Identifiers

DOI

1 reference

22 August 2017

1 reference