(Q37693855)

22 August 2017

1 reference

title

Histone deacetylase inhibitors (HDACIs). Structure--activity relationships: history and new QSAR perspectives (English)

1 reference

Dimitra Hadjipavlou-Litina

22 August 2017

author

series ordinal

2

object named as

Dimitra Hadjipavlou-Litina

1 reference

22 August 2017

Eleni Pontiki

1

1 reference

22 August 2017

publication date

16 February 2010

1 reference

Medicinal Research Reviews

22 August 2017

published in

1 reference

22 August 2017

volume

32

1 reference

22 August 2017

issue

1

1 reference

22 August 2017

page(s)

1-165

1 reference

Chemical origins of isoform selectivity in histone deacetylase inhibitors

22 August 2017

cites work

1 reference

Anticancer activities of histone deacetylase inhibitors

21 January 2018

1 reference

Histone deacetylase inhibitors: from bench to clinic

21 January 2018

1 reference

Translating the Histone Code

21 January 2018

1 reference

Histone deacetylases and cancer: causes and therapies

21 January 2018

1 reference

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

21 January 2018

1 reference

Histone deacetylase inhibitors

21 January 2018

1 reference

Histone deacetylation in epigenetics: an attractive target for anticancer therapy

21 January 2018

1 reference

21 January 2018

1 reference

Histone acetyltransferases

21 January 2018

1 reference

Chemistry of acetyl transfer by histone modifying enzymes: structure, mechanism and implications for effector design

21 January 2018

1 reference

The therapeutic uses of chromatin-modifying agents

21 January 2018

1 reference

Histone deacetylase inhibitors: molecular mechanisms of action

21 January 2018

1 reference

Histone deacetylases (HDACs): characterization of the classical HDAC family

21 January 2018

1 reference

The Sir2 family of protein deacetylases

21 January 2018

1 reference

Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies

21 January 2018

1 reference

Histone deacetylase inhibitors: discovery and development as anticancer agents

21 January 2018

1 reference

Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis.

21 January 2018

1 reference

Sirtuins in aging and age-related disease.

21 January 2018

1 reference

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

21 January 2018

1 reference

Deciphering NAD-dependent deacetylases

21 January 2018

1 reference

Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases

21 January 2018

1 reference

Histone deacetylase inhibitors: overview and perspectives

21 January 2018

1 reference

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

21 January 2018

1 reference

Histone Deacetylase Inhibitors

21 January 2018

1 reference

Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases

21 January 2018

1 reference

Prospects: histone deacetylase inhibitors

21 January 2018

1 reference

Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

21 January 2018

1 reference

Potential role of histone deacetylase inhibitors in mesothelioma: clinical experience with suberoylanilide hydroxamic acid

21 January 2018

1 reference

Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)

21 January 2018

1 reference

Histone deacetylase inhibitors in clinical development

21 January 2018

1 reference

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

21 January 2018

1 reference

Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.

21 January 2018

1 reference

Chronic oral administration of CI-994: a phase 1 study

21 January 2018

1 reference

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

21 January 2018

1 reference

Experimental therapy of malignant gliomas using the inhibitor of histone deacetylase MS-275.

21 January 2018

1 reference

Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme

21 January 2018

1 reference

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

1 reference

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases

21 January 2018

1 reference

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

Identification and characterization of novel sirtuin inhibitor scaffolds

21 January 2018

1 reference

An in silico approach to discovering novel inhibitors of human sirtuin type 2.

21 January 2018

1 reference

Inhibitors of Sir2: evaluation of splitomicin analogues

21 January 2018

1 reference

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

21 January 2018

1 reference

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

21 January 2018

1 reference

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

21 January 2018

1 reference

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

21 January 2018

1 reference

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

Biochemical characterization of Plasmodium falciparum Sir2, a NAD+-dependent deacetylase

21 January 2018

1 reference

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

21 January 2018

1 reference

Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate.

21 January 2018

1 reference

Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine

21 January 2018

1 reference

Structural bioinformatics and its impact to biomedical science

21 January 2018

1 reference

Molecular therapeutic target for type-2 diabetes

21 January 2018

1 reference

Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.

21 January 2018

1 reference

Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5.

21 January 2018

1 reference

Insights from modelling the 3D structure of the extracellular domain of alpha7 nicotinic acetylcholine receptor

21 January 2018

1 reference

An in-depth analysis of the biological functional studies based on the NMR M2 channel structure of influenza A virus

21 January 2018

1 reference

Virtual screening for SARS-CoV protease based on KZ7088 pharmacophore points

21 January 2018

1 reference

Energy-optimized structure of antifreeze protein and its binding mechanism

21 January 2018

1 reference

Heuristic molecular lipophilicity potential (HMLP): a 2D-QSAR study to LADH of molecular family pyrazole and derivatives

21 January 2018

1 reference

Multiple field three dimensional quantitative structure-activity relationship (MF-3D-QSAR).

21 January 2018

1 reference

Recent advances in QSAR and their applications in predicting the activities of chemical molecules, peptides and proteins for drug design

21 January 2018

1 reference

Proteomics, networks and connectivity indices.

21 January 2018

1 reference

Cell-PLoc: a package of Web servers for predicting subcellular localization of proteins in various organisms

21 January 2018

1 reference

MemType-2L: a web server for predicting membrane proteins and their types by incorporating evolution information through Pse-PSSM.

21 January 2018

1 reference

EzyPred: a top-down approach for predicting enzyme functional classes and subclasses

21 January 2018

1 reference

Bioinformatical analysis of G-protein-coupled receptors

21 January 2018

1 reference

GPCR-CA: A cellular automaton image approach for predicting G-protein-coupled receptor functional classes

21 January 2018

1 reference

ProtIdent: a web server for identifying proteases and their types by fusing functional domain and sequential evolution information

21 January 2018

1 reference

Identification of proteases and their types

21 January 2018

1 reference

Prediction of human immunodeficiency virus protease cleavage sites in proteins

21 January 2018

1 reference

Signal-CF: a subsite-coupled and window-fusing approach for predicting signal peptides.

21 January 2018

1 reference

Signal-3L: A 3-layer approach for predicting signal peptides

21 January 2018

1 reference

Quantitative structure-activity relationship study of histone deacetylase inhibitors

21 January 2018

1 reference

QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids

21 January 2018

1 reference

Exploration of a binding mode of indole amide analogues as potent histone deacetylase inhibitors and 3D-QSAR analyses

21 January 2018

1 reference

Indole amide hydroxamic acids as potent inhibitors of histone deacetylases

21 January 2018

1 reference

Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: novel classes of histone deacetylase inhibitors

21 January 2018

1 reference

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides

21 January 2018

1 reference

Identification of ligand features essential for HDACs inhibitors by pharmacophore modeling

21 January 2018

1 reference

Chemistry, biology, and QSAR studies of substituted biaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth

21 January 2018

1 reference

A survey of Hammett substituent constants and resonance and field parameters

21 January 2018

1 reference

21 January 2018

1 reference

QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach

21 January 2018

1 reference

Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives

21 January 2018

1 reference

Succinimide hydroxamic acids as potent inhibitors of histone deacetylase (HDAC).

21 January 2018

1 reference

Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin

21 January 2018

1 reference

Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors

21 January 2018

1 reference

Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.

21 January 2018

1 reference

Alpha-keto amides as inhibitors of histone deacetylase

21 January 2018

1 reference

Fluoro ketone inhibitors of hydrolytic enzymes

21 January 2018

1 reference

Heterocyclic ketones as inhibitors of histone deacetylase.

21 January 2018

1 reference

Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors

21 January 2018

1 reference

N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).

21 January 2018

1 reference

Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors

21 January 2018

1 reference

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

Trifluoromethyl ketones as inhibitors of histone deacetylase

21 January 2018

1 reference

3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors

21 January 2018

1 reference

Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group

21 January 2018

1 reference

(2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.

21 January 2018

1 reference

Differential protein acetylation induced by novel histone deacetylase inhibitors

21 January 2018

1 reference

Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group

21 January 2018

1 reference

Potent histone deacetylase inhibitors: N-hydroxybenzamides with antitumor activities

21 January 2018

1 reference

Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors

21 January 2018

1 reference

Differential binding of an SRF/NK-2/MEF2 transcription factor complex in normal versus neoplastic smooth muscle tissues

21 January 2018

1 reference

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity

21 January 2018

1 reference

Purification and characterization of a high molecular weight histone deacetylase complex (HD2) of maize embryos

21 January 2018

1 reference

Design and synthesis of phthalimide-type histone deacetylase inhibitors

21 January 2018

1 reference

Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates

21 January 2018

1 reference

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

1 reference

A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

21 January 2018

1 reference

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures

21 January 2018

1 reference

Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation

21 January 2018

1 reference

3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies

21 January 2018

1 reference

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.

21 January 2018

1 reference

Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.

21 January 2018

1 reference

X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature

21 January 2018

1 reference

Mechanism of carboxypeptidase A: hydration of a ketonic substrate analogue

21 January 2018

1 reference

Synthesis of rigid trichostatin A analogs as HDAC inhibitors

21 January 2018

1 reference

Major phase I biotransformation pathways of Trichostatin a in rat hepatocytes and in rat and human liver microsomes

21 January 2018

1 reference

HDAC6 is a microtubule-associated deacetylase

21 January 2018

1 reference

A series of novel, potent, and selective histone deacetylase inhibitors

21 January 2018

1 reference

Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors

21 January 2018

1 reference

Novel biological response modifiers: phthalimides with tumor necrosis factor-alpha production-regulating activity

21 January 2018

1 reference

Tumor necrosis factor-alpha production-inhibiting activity of phthalimide analogues on human leukemia THP-1 cells and a structure-activity relationship study

21 January 2018

1 reference

Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives.

21 January 2018

1 reference

Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid

21 January 2018

1 reference

Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework.

21 January 2018

1 reference

Structure-activity relationship studies of a series of novel delta-lactam-based histone deacetylase inhibitors

21 January 2018

1 reference

2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors

21 January 2018

1 reference

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

21 January 2018

1 reference

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity

21 January 2018

1 reference

Design and campaign synthesis of pyridine-based histone deacetylase inhibitors

21 January 2018

1 reference

Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities

21 January 2018

1 reference

A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum

21 January 2018

1 reference

Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.

21 January 2018

1 reference

21 January 2018

1 reference

On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors

21 January 2018

1 reference

21 January 2018

1 reference

Chem-bioinformatics and QSAR: a review of QSAR lacking positive hydrophobic terms

21 January 2018

1 reference

Cyclooxygenase (COX) inhibitors: a comparative QSAR study

21 January 2018

1 reference

From discovery to the coming generation of histone deacetylase inhibitors

21 January 2018

1 reference

Histone deacetylase as a new target for cancer chemotherapy.

21 January 2018

1 reference

Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice

21 January 2018

1 reference

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

21 January 2018

1 reference

Histone deacetylase inhibitors in cancer therapy

21 January 2018

1 reference

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

21 January 2018

1 reference

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

21 January 2018

1 reference

Synthesis and Biological Properties of Novel, Uracil-Containing Histone Deacetylase Inhibitors

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MED.20200

1 reference

22 August 2017

1 reference