(Q37697510)

English

Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat.

scientific article published on 29 March 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat. (English)

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Sprague-Dawley rat

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polycystic kidney disease

1 reference

based on heuristic

inferred from title

12

object named as

Norbert Gretz

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Europe PubMed Central

22 August 2017

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author name string

Susanne N E Boehn

1

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Sonja Spahn

2

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Europe PubMed Central

PMC publication ID

22 August 2017

Sabine Neudecker

3

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Andrea Keppler

4

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Marie-Thérèse Bihoreau

5

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Bettina Kränzlin

6

1 reference

Europe PubMed Central

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22 August 2017

Priyanka Pandey

7

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Sigrid C Hoffmann

8

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Li Li

9

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

Vicente E Torres

10

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Europe PubMed Central

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22 August 2017

Hermann-Josef Gröne

11

1 reference

Europe PubMed Central

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22 August 2017

language of work or name

0 references

publication date

29 March 2013

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Europe PubMed Central

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22 August 2017

Nephrology Dialysis Transplantation

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

28

1 reference

Europe PubMed Central

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22 August 2017

8

1 reference

Europe PubMed Central

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22 August 2017

2045-2058

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

2-Hydroxyestradiol slows progression of experimental polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Transgenic overexpression of Anks6(p.R823W) causes polycystic kidney disease in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Cyclic AMP-mediated cyst expansion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Polycystic kidney disease in Han:SPRD Cy rats is associated with elevated expression and mislocalization of SamCystin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Novel targets for the treatment of autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Autosomal dominant polycystic kidney disease: the last 3 years

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

The polycystic kidney disease-related proteins Bicc1 and SamCystin interact

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Genetics and pathogenesis of polycystic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Autosomal dominant polycystic kidney disease: modification of disease progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

The genetics and physiology of polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

cAMP regulates cell proliferation and cyst formation in autosomal polycystic kidney disease cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Genetic identification of two major modifier loci of polycystic kidney disease progression in pcy mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 August 2017

Catechol-O-methyltransferase-mediated metabolism of 4-hydroxyestradiol inhibits the growth of human renal cancer cells through the apoptotic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

6 September 2017

Global gene expression profiling in early-stage polycystic kidney disease in the Han:SPRD Cy rat identifies a role for RXR signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

6 September 2017

Autosomal dominant polycystic kidney disease--more than a renal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

6 September 2017

The relationship between cell proliferation, Cl- secretion, and renal cyst growth: a study using CFTR inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

14 September 2017

Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

14 September 2017

Genetic localization of interacting modifiers affecting severity in a murine model of polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

14 September 2017

Complex estrogenic regulation of catechol-O-methyltransferase (COMT) in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

Androgen receptor pathway in rats with autosomal dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

Inhibition of NF-kappa B transcription factor by catechol derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

A new rat model for polycystic kidney disease of humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

Antioxidant properties of nitecapone (OR-462)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

23 June 2018

Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Primary cilia and signaling pathways in mammalian development, health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

17beta-Estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Entacapone protects from angiotensin II-induced inflammation and renal injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Characterization of a major modifier locus for polycystic kidney disease (Modpkdr1) in the Han:SPRD(cy/+) rat in a region conserved with a mouse modifier locus for Alport syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Relationship between renal volume growth and renal function in autosomal dominant polycystic kidney disease: a longitudinal study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

A systematic statistical linear modeling approach to oligonucleotide array experiments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Location of mutations within the PKD2 gene influences clinical outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Blood pressure-independent effects in rats with human renin and angiotensinogen genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Phytoestrogen content of purified, open- and closed-formula laboratory animal diets.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

The phytoestrogen content of rodent diets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Nitecapone: a nitric oxide radical scavenger.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

1 September 2018

Kinesin Family Member 12 Is a Candidate Polycystic Kidney Disease Modifier in the cpk Mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3983428

3 December 2018

The Position of the Polycystic Kidney Disease 1 (PKD1) Gene Mutation Correlates with the Severity of Renal Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Volume progression in polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalph

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mosaicism in autosomal dominant polycystic kidney disease revealed by genetic testing to enable living related renal transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic AMP, at the hub of the cystic cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic analysis of a quantitative trait in a mouse model of polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soy protein modification of rat polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic modifiers of polycystic kidney disease in intersubspecific KAT2J mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of estradiol on catechol-O-methyltransferase activity in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-inflammatory properties of estrogen. I. In vivo suppression of leukocyte production in bone marrow and redistribution of peripheral blood neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic Heterogeneity of Polycystic Kidney Disease in Europe1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal-dominant polycystic kidney disease in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progression of chronic renal failure in a rat strain with autosomal dominant polycystic kidney disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of a murine recessive polycystic kidney disease mutation and modifying loci that affect disease severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gender-dependent disease severity in autosomal polycystic kidney disease of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Location of the first genetic locus, PKDr1, controlling autosomal dominant polycystic kidney disease in Han:SPRD cy/+ rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggravation of polycystic kidney disease in Han:SPRD rats by buthionine sulfoximine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined antioxidant and COMT inhibitor treatment reverses renal abnormalities in diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23543593

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NDT/GFT014

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

release_e3apuugy2ffirkaommdvqrm2lm

1 reference

https://api.fatcat.wiki/v0/release/e3apuugy2ffirkaommdvqrm2lm

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

22 August 2017

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