(Q37709367)

22 August 2017

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title

Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives (English)

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22 August 2017

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N R Srinivas

1

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22 August 2017

language of work or name

English

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publication date

1 May 2010

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22 August 2017

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22 August 2017

volume

40

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22 August 2017

issue

5

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22 August 2017

page(s)

357-367

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Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2.

22 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Hepatic contribution to a marked increase in the plasma concentration of baicalin after oral administration of its aglycone, baicalein, in multidrug resistance-associated protein 2-deficient rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Artemisinin--a possible CYP2B6 probe substrate?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Influence of the cytochrome P450 2B6 genotype on population pharmacokinetics of efavirenz in human immunodeficiency virus patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Induction of cytochrome P450 2B6 activity by the herbal medicine baicalin as measured by bupropion hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of ezetimibe (Zetia).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Determination of baicalin in rat cerebrospinal fluid and blood using microdialysis coupled with ultra-performance liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Uptake of irinotecan metabolite SN-38 by the human intestinal cell line Caco-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Species- and disposition model-dependent metabolism of raloxifene in gut and liver: role of UGT1A10.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Baicalin, an inhibitor of HIV-1 production in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

HPLC with electrochemical detection to examine the pharmacokinetics of baicalin and baicalein in rat plasma after oral administration of a Kampo medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Increased oral AUC of baicalin in streptozotocin-induced diabetic rats due to the increased activity of intestinal beta-glucuronidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Effects of Labrasol on the corneal drug delivery of baicalin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

A study of the pharmacokinetic interaction of istradefylline, a novel therapeutic for Parkinson's disease, and atorvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Efflux transporter-mediated interactions with atorvastatin--interesting findings with multiple substrates: istradefylline, verapamil, and rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Determination of human plasma protein binding of baicalin by ultrafiltration and high-performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Role of CYP2B6 in stereoselective human methadone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Baicalin reduces mitochondrial damage in streptozotocin-induced diabetic Wistar rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Interaction of baicalin and baicalein with antibiotics in the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Absorption and enterohepatic circulation of baicalin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Effect of baicalin and berberine on transport of nimodipine on primary-cultured, rat brain microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Role of intestinal first-pass metabolism of baicalein in its absorption process.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498251003663724

10.3109/00498251003663724

21 January 2018

Identifiers

DOI

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22 August 2017

1 reference