(Q37728981)

22 August 2017

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title

PARP and PARG inhibitors--new therapeutic targets in cancer treatment (English)

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22 August 2017

Nilufer Jasmine Selimah Fauzee

series ordinal

1

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PubMed ID

20383759

22 August 2017

Juan Pan

series ordinal

2

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PubMed ID

20383759

22 August 2017

Ya-lan Wang

series ordinal

3

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22 August 2017

12 April 2010

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Pathology Oncology Research

22 August 2017

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22 August 2017

16

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22 August 2017

4

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22 August 2017

469-478

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https://scigraph.springernature.com/pub.10.1007/s12253-010-9266-6

22 August 2017

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cites work

Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Modulation of poly(ADP-ribose) polymerase during neutrophilic and monocytic differentiation of promyelocytic (NB4) and myelocytic (HL-60) leukaemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Involvement of poly(ADP-ribose) polymerase in trophoblastic cell differentiation during tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Medulloblastoma in mice lacking p53 and PARP: all roads lead to Gli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Role of angiogenesis in tumor growth and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

PARP inhibitors for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Novel inhibitors of poly(ADP-ribose) synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12253-010-9266-6

Poly(ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells

21 January 2018

1 reference

12 December 2020

Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34.

1 reference

12 December 2020

Poly(ADP-ribose) glycohydrolase inhibitor as chemosensitiser of malignant melanoma for temozolomide

1 reference

12 December 2020

Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion

1 reference

12 December 2020

Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster

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12 December 2020

Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies

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12 December 2020

Oxidative stress inhibits apoptosis in human lymphoma cells

1 reference

12 December 2020

Protective effects of PARP inhibition on liver microcirculation and function after haemorrhagic shock and resuscitation in male rats

1 reference

12 December 2020

Syncytiotrophoblastic giant cells in teratocarcinoma-like tumors derived from Parp-disrupted mouse embryonic stem cells.

1 reference

12 December 2020

PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.

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12 December 2020

A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.

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12 December 2020

Implicating PARP and NAD+ depletion in type I diabetes

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12 December 2020

Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

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12 December 2020

Poly(ADP-ribose) polymerase inhibition in oxidant-stressed endothelial cells prevents oncosis and permits caspase activation and apoptosis

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12 December 2020

PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases.

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12 December 2020

Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion

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12 December 2020

Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor

1 reference

12 December 2020

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

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12 December 2020

Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers

1 reference

12 December 2020

Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)

1 reference

12 December 2020

Overexpression of poly(ADP-ribose) polymerase promotes cell cycle arrest and inhibits neutrophilic differentiation of NB4 acute promyelocytic leukemia cells

1 reference

12 December 2020

PARP-1 modifies the effectiveness of p53-mediated DNA damage response.

1 reference

12 December 2020

Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death

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12 December 2020

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1 reference

12 December 2020

Down-modulation of poly(ADP-ribose) polymerase-1 (PARP-1) in human TUR leukemia cells restores transcriptional responsiveness for differentiation and cell cycle arrest

1 reference

12 December 2020

Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase

1 reference

12 December 2020

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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12 December 2020

The Emerging Role of PARP Inhibitors in the Treatment of Epithelial Ovarian Cancer

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12 December 2020

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis

1 reference

12 December 2020

[Inhibitory effect of 5-aminoisoquinolinone on PARP activity in colon carcinoma cell line HT-29]

1 reference

12 December 2020

Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase

1 reference

12 December 2020

Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

1 reference

12 December 2020

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

1 reference

12 December 2020

Targeting the DNA repair defect of BRCA tumours

1 reference

12 December 2020

Transcriptional coactivation of nuclear factor-kappaB-dependent gene expression by p300 is regulated by poly(ADP)-ribose polymerase-1.

1 reference

12 December 2020

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

12 December 2020

A key role for poly(ADP-ribose) polymerase-1 activity during human dendritic cell maturation

1 reference

12 December 2020

Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma

1 reference

12 December 2020

Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells

1 reference

12 December 2020

Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice

1 reference

12 December 2020

Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models

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12 December 2020

An improved nonisotopic test to screen a large series of new inhibitor molecules of poly(ADP-ribose) polymerase activity for therapeutic applications

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12 December 2020

Identification of interaction partners for the basic-helix-loop-helix protein E47.

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12 December 2020

Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis

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12 December 2020

A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

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12 December 2020

Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells

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12 December 2020

Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma

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12 December 2020

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

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12 December 2020

Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes

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12 December 2020

Participation of poly(ADP-ribosyl)ation in the depression of RNA synthesis caused by treatment of mouse lymphoma cells with methylnitrosourea

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12 December 2020

A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

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12 December 2020

Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks

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12 December 2020

ATP for the DNA ligation step in base excision repair is generated from poly(ADP-ribose).

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12 December 2020

PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis.

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12 December 2020

Mediation of cell death by poly(ADP-ribose) polymerase-1.

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12 December 2020

Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

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12 December 2020

Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice

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12 December 2020

Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells

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12 December 2020

Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis

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12 December 2020

MNNG-induced cell death is controlled by interactions between PARP-1, poly(ADP-ribose) glycohydrolase, and XRCC1.

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12 December 2020

PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator

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12 December 2020

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression

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12 December 2020

A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity

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12 December 2020

Mono-galloyl glucose derivatives are potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors and partially reduce PARP-1-dependent cell death

1 reference

12 December 2020

Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor

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12 December 2020

Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.

1 reference

12 December 2020

Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90

1 reference

12 December 2020

Nicotinamide Offers Multiple Protective Mechanisms in Stroke as a Precursor for NAD<sup>+</sup>, as a PARP Inhibitor and by Partial Restoration of Mitochondrial Function

1 reference

12 December 2020

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

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12 December 2020

Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis

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12 December 2020

Poly(ADP-ribose) polymerase-1 is a component of the oncogenic T-cell factor-4/beta-catenin complex.

1 reference

12 December 2020

Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1

1 reference

12 December 2020

Poly(ADP-ribose) synthesis in human cervical cancer cell — Diagnostic cytological usefulness

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12 December 2020

Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells

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12 December 2020

PolyADP-ribosylation and cancer

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12 December 2020

PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion

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12 December 2020

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells

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12 December 2020

PARP goes transcription

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12 December 2020

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

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12 December 2020

Differential PARP cleavage: an indication for existence of multiple forms of cell death in human gliomas.

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12 December 2020

Preclinical modeling of a phase 0 clinical trial: qualification of a pharmacodynamic assay of poly (ADP-ribose) polymerase in tumor biopsies of mouse xenografts

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12 December 2020

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

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12 December 2020

Functional interactions of p53 with poly(ADP-ribose) polymerase (PARP) during apoptosis following DNA damage: covalent poly(ADP-ribosyl)ation of p53 by exogenous PARP and noncovalent binding of p53 to the M(r) 85,000 proteolytic fragment

1 reference

12 December 2020

Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells

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12 December 2020

Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated

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12 December 2020

ADP-ribosylation of nuclear proteins in normal lymphocytes and in low-grade malignant non-Hodgkin lymphoma cells.

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12 December 2020

PARP is important for genomic stability but dispensable in apoptosis

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12 December 2020

Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors

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12 December 2020

Spatial and functional relationship between poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in the brain

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12 December 2020

BRCA1 and BRCA2 in breast cancer

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12 December 2020

Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors.

1 reference

12 December 2020

10.1007/S12253-010-9266-6

Identifiers

DOI

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22 August 2017

1 reference

PubMed ID

20383759