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Drugs that modulate aging: the promising yet difficult path ahead
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
retrieved
22 August 2017
title
Drugs that modulate aging: the promising yet difficult path ahead
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
retrieved
22 August 2017
author
Brian K Kennedy
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
author name string
Juniper K Pennypacker
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
publication date
20 November 2013
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
retrieved
22 August 2017
published in
Translational Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
volume
163
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
issue
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
page(s)
456-465
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Genetics: influence of TOR kinase on lifespan in C. elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Life span of individual yeast cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Extended longevity in mice lacking the insulin receptor in adipose tissue
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Why do we age?
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Extrachromosomal rDNA circles--a cause of aging in yeast
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
A C. elegans mutant that lives twice as long as wild type
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Divergent roles of RAS1 and RAS2 in yeast longevity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Genetics of life history in Drosophila melanogaster. II. Exploratory selection experiments.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 August 2017
Evolution of ageing
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PubMed Central
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23 August 2017
Mechanistic target of rapamycin inhibitors in solid organ transplantation: from benchside to clinical use.
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6 September 2017
Cardiovascular implications of antihyperglycemic therapies for type 2 diabetes.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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6 September 2017
Ideal lipid profile and genes for an extended life span
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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6 September 2017
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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14 September 2017
Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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28 September 2017
Dietary restriction: standing up for sirtuins
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 June 2018
Dwarf mice and the ageing process.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 June 2018
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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23 June 2018
Genetic control of adult life span in Drosophila melanogaster
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
retrieved
23 June 2018
Three mutants that extend both mean and maximum life span of the nematode, Caenorhabditis elegans, define the age-1 gene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
retrieved
23 June 2018
dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
retrieved
1 September 2018
Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Effects of resveratrol on longevity, cognitive ability and aging-related histological markers in the annual fish Nothobranchius guentheri.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasic
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Rates of behavior and aging specified by mitochondrial function during development
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Selection for life span in Drosophila melanogaster
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4004650
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1 September 2018
Pleiotropy, Natural Selection, and the Evolution of Senescence
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FJ.TRSL.2013.11.007
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7 January 2021
Type 5 adenylyl cyclase disruption increases longevity and protects against stress
1 reference
stated in
Crossref
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https://api.crossref.org/works/10.1016%2FJ.TRSL.2013.11.007
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7 January 2021
Telomere/Telomerase system: a new target of statins pleiotropic effect?
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FJ.TRSL.2013.11.007
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7 January 2021
Identifiers
DOI
10.1016/J.TRSL.2013.11.007
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
PMC publication ID
4004650
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
PubMed publication ID
24316383
1 reference
stated in
Europe PubMed Central
PMC publication ID
4004650
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24316383%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 June 2020
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