(Q37747401)

22 August 2017

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title

Antibacterial oxazolidinones: emerging structure-toxicity relationships (English)

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22 August 2017

1

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22 August 2017

publication date

1 May 2010

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Expert Review of Anti-infective Therapy

22 August 2017

published in

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22 August 2017

volume

8

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22 August 2017

issue

5

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22 August 2017

page(s)

565-574

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Oxazolidinone Structure–Activity Relationships Leading to Linezolid

22 August 2017

cites work

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Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections

21 January 2018

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The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.

21 January 2018

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

21 January 2018

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Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit

21 January 2018

1 reference

Linezolid in vitro: mechanism and antibacterial spectrum

21 January 2018

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Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with Gram-positive infections

21 January 2018

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Efficacy of linezolid versus comparator therapies in Gram-positive infections

21 January 2018

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In vitro susceptibilities of zygomycetes to conventional and new antifungals

21 January 2018

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Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome

21 January 2018

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Oxazolidinone antibacterial agents: a critical review

21 January 2018

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Recent developments in the identification of novel oxazolidinone antibacterial agents

21 January 2018

1 reference

21 January 2018

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Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence

21 January 2018

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Linezolid Treatment for Osteomyelitis due to Staphylococcus Epidermidis with Reduced Vancomycin Susceptibility

21 January 2018

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Benefit-risk assessment of linezolid for serious gram-positive bacterial infections

21 January 2018

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R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance

21 January 2018

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In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.

21 January 2018

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In vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens

21 January 2018

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Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics

21 January 2018

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The synthesis and biological evaluation of a novel series of antimicrobials of the oxazolidinone class

21 January 2018

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Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones

21 January 2018

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Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis

21 January 2018

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Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A.

21 January 2018

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Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERI.10.26

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22 August 2017

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