(Q37754532)

22 August 2017

title

The role of the complement system in CNS inflammatory diseases (English)

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22 August 2017

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Philip F Stahel

1

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22 August 2017

Scott R Barnum

series ordinal

2

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22 August 2017

publication date

1 May 2006

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Expert Review of Clinical Immunology

22 August 2017

published in

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22 August 2017

volume

2

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22 August 2017

issue

3

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22 August 2017

page(s)

445-456

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Complement: structure, functions, evolution, and viral molecular mimicry

22 August 2017

cites work

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Complement: central to innate immunity and bridging to adaptive responses.

21 January 2018

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Novel biological networks modulated by complement

21 January 2018

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Inflammation and Alzheimer's disease

21 January 2018

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B cells and antibodies in CNS demyelinating disease

21 January 2018

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Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Experimental allergic encephalomyelitis in cobra venom factor-treated and C4-deficient guinea pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Murine complement C4 is not required for experimental autoimmune encephalomyelitis

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement anaphylatoxin receptors on neurons: new tricks for old receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Production of experimental allergic encephalomyelitis with the aid of pertussigen in mouse strains considered genetically resistant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement C5 in experimental autoimmune encephalomyelitis (EAE) facilitates remyelination and prevents gliosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study.

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

The role of complement in Alzheimer's disease pathology

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Aβ, aging, and Alzheimer's disease: A tale, models, and hypotheses

21 January 2018

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https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement activation by beta-amyloid in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Aspartate residue 7 in amyloid beta-protein is critical for classical complement pathway activation: implications for Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement-dependent proinflammatory properties of the Alzheimer's disease beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement activation by neurofibrillary tangles in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Enhanced aggregation and beta structure of amyloid beta peptide after coincubation with C1q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Transgenic mice overexpressing the complement inhibitor crry as a soluble protein are protected from antibody-induced glomerular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Localization of Th-cell subsets in inflammation: differential thresholds for extravasation of Th1 and Th2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement in ischemia reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Brain injury and neuropsychological outcome after coronary artery surgery are affected by complement activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement activation in the central nervous system following blood-brain barrier damage in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Systemic complement activation in ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement component 9 activation, consumption, and neuronal deposition in the post-hypoxic-ischemic central nervous system of human newborn infants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Expression of the complement C3a and C5a receptors after permanent focal ischemia: An alternative interpretation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Ischemic tolerance and endogenous neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Pathobiology of ischaemic stroke: an integrated view

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Ischemic injury and faulty gene transcripts in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Intracerebroventricular injection of the terminal complement complex causes inflammatory reaction in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Should dexamethasone be part of routine therapy of bacterial meningitis in industrialised countries?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Glucocorticoid therapy in neurologic critical care

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Development of adjunctive therapies for bacterial meningitis and lessons from knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Pathogenesis and pathophysiology of pneumococcal meningitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Pathophysiology of bacterial meningitis: mechanism(s) of neuronal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Bacterial meningitis: complement gene expression in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

CD46 in meningococcal disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

COMPLEMENT AND ITS COMPONENT FRACTIONS IN CEREBROSPINAL FLUID IN INFLAMMATORY CEREBROSPINAL DISEASES.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Morphological study in the early stages of complement C5a fragment-induced experimental meningitis: activation of macrophages and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement components of the innate immune system in health and disease in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

A controlled trial of natalizumab for relapsing multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

C3a expressed in the central nervous system protects against LPS-induced shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Vaccinia virus complement control protein enhances functional recovery after traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Administration of vaccinia virus complement control protein shows significant cognitive improvement in a mild injury model

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Therapeutic potential of targeting the complement cascade in critical care medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement therapeutics; history and current progress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

The alternative pathway of complement in disease: opportunities for therapeutic targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Opportunities for new therapies based on the natural regulators of complement activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Inflammatory Signals Induce Neurotrophin Expression in Human Microglial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement interactions with amyloid β1–42: A nidus for inflammation in AD brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Deficiency of the complement regulator CD59a enhances disease severity, demyelination and axonal injury in murine acute experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Humoral immunity in brain aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

The role of the complement system in traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Glial responses, clusterin, and complement in permanent focal cerebral ischemia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

C1q-deficiency is neuroprotective against hypoxic-ischemic brain injury in neonatal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Expression of Receptors for Complement Anaphylatoxins C3a and C5a Following Permanent Focal Cerebral Ischemia in the Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement activation in the human brain after traumatic head injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Closed head injury--an inflammatory disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement C3 and factor B cerebrospinal fluid concentrations in bacterial and aseptic meningitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Intrathecal synthesis of complement components C3c and C4 in the central nervous system infections with signs of the acute serous meningitis syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

Complement as a biomarker in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F1744666X.2.3.445

21 January 2018

Identifiers

DOI

10.1586/1744666X.2.3.445

1 reference

22 August 2017

1 reference