(Q37763512)

22 August 2017

1 reference

title

Restless legs syndrome: pathophysiology, clinical presentation and management (English)

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22 August 2017

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restless legs syndrome

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1

Claudia Trenkwalder

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22 August 2017

2

Walter Paulus

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22 August 2017

language of work or name

English

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publication date

1 June 2010

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22 August 2017

published in

Nature Reviews Neurology

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22 August 2017

volume

6

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22 August 2017

issue

6

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22 August 2017

page(s)

337-346

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https://scigraph.springernature.com/pub.10.1038/nrneurol.2010.55

22 August 2017

exact match

0 references

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31 March 2020

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31 March 2020

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Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome

31 March 2020

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The reliability, validity and responsiveness of the International Restless Legs Syndrome Study Group rating scale and subscales in a clinical-trial setting.

31 March 2020

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Validation of the Restless Legs Syndrome Quality of Life Instrument (RLS-QLI): findings of a consortium of national experts and the RLS Foundation

31 March 2020

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Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

31 March 2020

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Dopamine and the spinal cord in restless legs syndrome: Does spinal cord physiology reveal a basis for augmentation?

31 March 2020

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Restless legs syndrome: revisiting the dopamine hypothesis from the spinal cord perspective

31 March 2020

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Motoneuron excitability: the importance of neuromodulatory inputs

31 March 2020

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Dose-dependent inverted U-shaped effect of dopamine (D2-like) receptor activation on focal and nonfocal plasticity in humans.

31 March 2020

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Serotonin affects transcranial direct current-induced neuroplasticity in humans.

31 March 2020

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Dopamine agonists restore cortical plasticity in patients with idiopathic restless legs syndrome.

31 March 2020

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Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome

31 March 2020

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Spinal cord dopamine receptor expression and function in mice with 6-OHDA lesion of the A11 nucleus and dietary iron deprivation.

31 March 2020

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Delayed L-DOPA-induced hyperalgesia

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Changes in cortical dopamine D1 receptor binding associated with cognitive training.

31 March 2020

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Lack of D2 receptor mediated regulation of dopamine synthesis in A11 diencephalospinal neurons in male and female mice.

31 March 2020

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Recent advances in the diagnosis, genetics and treatment of restless legs syndrome.

31 March 2020

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Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions

31 March 2020

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PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome

31 March 2020

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Cerebral generators involved in the pathogenesis of the restless legs syndrome

31 March 2020

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Cortical grey matter alterations in idiopathic restless legs syndrome: An optimized voxel-based morphometry study

31 March 2020

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Cerebral white matter alterations in idiopathic restless legs syndrome, as measured by diffusion tensor imaging.

31 March 2020

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Bilateral thalamic gray matter changes in patients with restless legs syndrome.

31 March 2020

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Lack of specific gray matter alterations in restless legs syndrome in elderly subjects.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Voxel-based morphometry in unmedicated patients with restless legs syndrome

31 March 2020

1 reference

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Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding.

31 March 2020

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Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome

31 March 2020

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Influence of cabergoline on motor excitability in patients with restless legs syndrome

31 March 2020

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Cabergoline reverses cortical hyperexcitability in patients with restless legs syndrome.

31 March 2020

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The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study

31 March 2020

1 reference

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Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

31 March 2020

1 reference

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Ferritin subunits in CSF are decreased in restless legs syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Circadian changes in CSF dopaminergic measures in restless legs syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

T2 relaxometry and fMRI of the brain in late-onset restless legs syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

The role of iron in restless legs syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Pathophysiology of restless legs syndrome: evidence for iron involvement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

MRI-determined regional brain iron concentrations in early- and late-onset restless legs syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Transcranial ultrasound shows nigral hypoechogenicity in restless legs syndrome

31 March 2020

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Substantia nigra hypoechogenicity: definition and findings in restless legs syndrome.

31 March 2020

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Disturbance of iron metabolism as a contributing factor to SN hyperechogenicity in Parkinson's disease: implications for idiopathic and monogenetic forms

31 March 2020

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Locomotion is increased in a11-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Iron-deficiency sensitizes mice to acute pain stimuli and formalin-induced nociception

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Clinical correlates of 6-hydroxydopamine injections into A11 dopaminergic neurons in rats: a possible model for restless legs syndrome.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Projections of diencephalic dopamine neurons into the spinal cord in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Periodic limb movements in sleep: state-dependent excitability of the spinal flexor reflex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Abnormal H-reflexes in periodic limb movement disorder; impact on understanding the pathophysiology of the disorder.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome

31 March 2020

1 reference

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Idiopathic restless legs syndrome: abnormalities in central somatosensory processing

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Cognitive behavioural group therapy to improve patients' strategies for coping with restless legs syndrome: a proof-of-concept trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Where dopamine meets opioids: a meta-analysis of the placebo effect in restless legs syndrome treatment studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Iron status and restless legs syndrome in the elderly

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Augmentation in restless legs syndrome is associated with low ferritin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Pergolide: treatment of choice in restless legs syndrome (RLS) and nocturnal myoclonus syndrome (NMS). A double-blind randomized crossover trial of pergolide versus L-Dopa

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Treatment of idiopathic restless legs syndrome (RLS) with slow-release valproic acid compared with slow-release levodopa/benserazid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Augmentation of the restless legs syndrome with carbidopa/levodopa.

31 March 2020

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One‐year treatment with standard and sustained‐release levodopa: Appropriate long‐term treatment of restless legs syndrome?

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Efficacy and safety of pramipexole in idiopathic restless legs syndrome: a polysomnographic dose-finding study--the PRELUDE study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Efficacy of cabergoline in restless legs syndrome: a placebo-controlled study with polysomnography (CATOR).

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Ropinirole is effective in the treatment of restless legs syndrome. TREAT RLS 2: a 12-week, double-blind, randomized, parallel-group, placebo-controlled study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Randomized, double-blind, placebo-controlled, short-term trial of ropinirole in restless legs syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Ropinirole in the treatment of patients with restless legs syndrome: a US-based randomized, double-blind, placebo-controlled clinical trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Gabapentin versus Ropinirole in the Treatment of Idiopathic Restless Legs Syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Effect of ropinirole on sleep outcomes in patients with restless legs syndrome: meta-analysis of pooled individual patient data from randomized controlled trials

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Ropinirole is effective in the long-term management of restless legs syndrome: a randomized controlled trial.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

A 52-week open-label study of the long-term safety of ropinirole in patients with restless legs syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Efficacy and safety of pramipexole in restless legs syndrome.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Efficacy of pramipexole in restless legs syndrome: a six-week, multicenter, randomized, double-blind study (effect-RLS study)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Effect of pramipexole on RLS symptoms and sleep: a randomized, double-blind, placebo-controlled trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Patch application of the dopamine agonist rotigotine to patients with moderate to advanced stages of restless legs syndrome: a double-blind, placebo-controlled pilot study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Restless legs syndrome augmentation associated with tramadol.

31 March 2020

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Augmentation of restless legs syndrome with long-term tramadol treatment

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome

31 March 2020

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Successful treatment of the idiopathic restless legs syndrome in a randomized double-blind trial of oxycodone versus placebo.

31 March 2020

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Long-term follow-up on restless legs syndrome patients treated with opioids.

31 March 2020

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Pregabalin in restless legs syndrome with and without neuropathic pain

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

A crossover study of gabapentin in treatment of restless legs syndrome among hemodialysis patients

31 March 2020

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Randomized, double-blind, placebo-controlled study of XP13512/GSK1838262 in patients with RLS.

31 March 2020

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Gabapentin enacarbil in restless legs syndrome: a phase 2b, 2-week, randomized, double-blind, placebo-controlled trial

31 March 2020

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Restless legs syndrome induced by topiramate: two more cases.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Clonazepam and vibration in restless legs syndrome.

31 March 2020

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Restless legs syndrome (RLS) and periodic limb movement disorder (PLMD): acute placebo-controlled sleep laboratory studies with clonazepam

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Double-blind evaluation of clonazepam on periodic leg movements in sleep

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Zolpidem in restless legs syndrome

31 March 2020

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A randomized, double-blind placebo-controlled trial of iron in restless legs syndrome.

31 March 2020

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A double-blind, placebo-controlled trial of intravenous iron dextran therapy in patients with ESRD and restless legs syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Repeated IV doses of iron provides effective supplemental treatment of restless legs syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

A randomized, double-blind, placebo controlled, multi-center study of intravenous iron sucrose and placebo in the treatment of restless legs syndrome.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Amantadine is beneficial in restless legs syndrome

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRNEUROL.2010.55

The MOS 36-ltem Short-Form Health Survey (SF-36)

31 March 2020

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Practice parameters for the indications for polysomnography and related procedures: an update for 2005.

31 March 2020

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12 December 2020

L-dopa therapy of uremic and idiopathic restless legs syndrome: a double-blind, crossover trial.

1 reference

12 December 2020

Thermal hypoaesthesia differentiates secondary restless legs syndrome associated with small fibre neuropathy from primary restless legs syndrome.

1 reference

12 December 2020

Periodic leg movements in sleep with restless legs syndrome: effect of clonazepam treatment

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12 December 2020

Rapid onset of action of levodopa in restless legs syndrome: a double-blind, randomized, multicenter, crossover trial.

1 reference

12 December 2020

Randomized, double-blind, placebo-controlled study of clonidine in restless legs syndrome.

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12 December 2020

A double-blind, placebo-controlled study of the treatment of periodic limb movements in sleep using carbidopa/levodopa and propoxyphene.

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12 December 2020

L-DOPA/carbidopa for nocturnal movement disorders in uremia.

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12 December 2020

L-dopa induces opposing effects on pain in intact rats: (-)-sulpiride, SCH 23390 or alpha-methyl-DL-p-tyrosine methylester hydrochloride reveals profound hyperalgesia in large antinociceptive doses.

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12 December 2020

Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries

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Identifiers

DOI

10.1038/NRNEUROL.2010.55

1 reference

22 August 2017

1 reference