(Q37764794)

22 August 2017

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title

DNA repair in mammalian mitochondria: Much more than we thought? (English)

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22 August 2017

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Pingfang Liu

1

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PubMed ID

20544882

22 August 2017

Bruce Demple

series ordinal

2

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22 August 2017

1 June 2010

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Environmental and Molecular Mutagenesis

22 August 2017

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22 August 2017

51

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22 August 2017

417-426

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22 August 2017

5

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Molecular genetics and structural biology of human MutT homolog, MTH1.

22 August 2017

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Expression and differential intracellular localization of two major forms of human 8-oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs

21 January 2018

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TFAM-dependent and independent dynamics of mtDNA levels in C2C12 myoblasts caused by redox stress

21 January 2018

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Mitochondrial DNA mutations and human disease

21 January 2018

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Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

21 January 2018

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7 January 2021

Human mitochondrial DNA is packaged with TFAM.

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7 January 2021

Is there more to aging than mitochondrial DNA and reactive oxygen species?

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7 January 2021

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes

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7 January 2021

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

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7 January 2021

RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes

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7 January 2021

Repair of mtDNA in vertebrates

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7 January 2021

Multiple pathways for sorting mitochondrial precursor proteins

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7 January 2021

Replication of mitochondrial DNA occurs by strand displacement with alternative light-strand origins, not via a strand-coupled mechanism

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7 January 2021

Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents

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7 January 2021

DNA polymerase gamma and mitochondrial disease: understanding the consequence of POLG mutations.

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7 January 2021

Mitochondrial DNA mutations in human cancer

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7 January 2021

Dynamic localization of an Okazaki fragment processing protein suggests a novel role in telomere replication

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7 January 2021

The absence of a pyrimidine dimer repair mechanism in mammalian mitochondria

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7 January 2021

Mammalian mitochondrial extracts possess DNA end-binding activity.

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7 January 2021

DNA2 resolves expanding flap in mitochondrial base excision repair

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7 January 2021

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

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7 January 2021

Primers for mitochondrial DNA replication generated by endonuclease G.

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7 January 2021

EndoG is dispensable in embryogenesis and apoptosis

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7 January 2021

A Ca2+-induced mitochondrial permeability transition causes complete release of rat liver endonuclease G activity from its exclusive location within the mitochondrial intermembrane space. Identification of a novel endo-exonuclease activity residing

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7 January 2021

Mitochondrial DNA, base excision repair and neurodegeneration

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7 January 2021

Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

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7 January 2021

Covalent trapping of human DNA polymerase beta by the oxidative DNA lesion 2-deoxyribonolactone

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7 January 2021

Dynamics and diversions in base excision DNA repair of oxidized abasic lesions

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7 January 2021

Human Dna2 is a nuclear and mitochondrial DNA maintenance protein

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7 January 2021

Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis

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7 January 2021

Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons

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7 January 2021

Mutagenesis by 8-oxoguanine: an enemy within

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7 January 2021

Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase

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7 January 2021

Formation of novel C1-oxidised abasic sites in alkylperoxyl radical-damaged plasmid DNA

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7 January 2021

The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity

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7 January 2021

mtDNA mutations and common neurodegenerative disorders

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7 January 2021

Repair of formamidopyrimidines in DNA involves different glycosylases: role of the OGG1, NTH1, and NEIL1 enzymes

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7 January 2021

Endonuclease G: a role for the enzyme in recombination and cellular proliferation

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7 January 2021

Age-associated change in mitochondrial DNA damage.

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7 January 2021

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death.

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7 January 2021

Action of mitochondrial endonuclease G on DNA damaged by L-ascorbic acid, peplomycin, and cis-diamminedichloroplatinum (II)

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7 January 2021

Differential intracellular localization of the human and mouse endonuclease III homologs and analysis of the sorting signals

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7 January 2021

Generation and characterization of endonuclease G null mice

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7 January 2021

ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis

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7 January 2021

Prominent mitochondrial DNA recombination intermediates in human heart muscle.

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7 January 2021

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

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7 January 2021

Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

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7 January 2021

Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.

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7 January 2021

Isolation of human Dna2 endonuclease and characterization of its enzymatic properties

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7 January 2021

Recombination of human mitochondrial DNA.

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7 January 2021

Cross-linking of 2-deoxyribonolactone and its beta-elimination product by base excision repair enzymes

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7 January 2021

Generation of rho0 cells utilizing a mitochondrially targeted restriction endonuclease and comparative analyses

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7 January 2021

Double strand break rejoining by mammalian mitochondrial extracts.

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7 January 2021

Nuclear and mitochondrial DNA repair: similar pathways?

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7 January 2021

Initiation of mitochondrial DNA replication by transcription and R-loop processing

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7 January 2021

Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria

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7 January 2021

Mismatch repair activity in mammalian mitochondria

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7 January 2021

Biochemical analysis of human Dna2

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7 January 2021

Single strand annealing and ATP-independent strand exchange activities of yeast and human DNA2: possible role in Okazaki fragment maturation

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7 January 2021

Rescue of arrested replication forks by homologous recombination

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7 January 2021

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

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7 January 2021

Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene

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7 January 2021

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

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7 January 2021

Mitochondrial DNA and human evolution.

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7 January 2021

mtDNA mutations increase tumorigenicity in prostate cancer

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7 January 2021

Families of mtDNA re-arrangements can be detected in patients with mtDNA deletions: duplications may be a transient intermediate form.

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7 January 2021

Repair of pyrimidine dimers in nuclear and mitochondrial DNA of yeast irradiated with low doses of ultraviolet light

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7 January 2021

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase gamma replication fidelity.

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7 January 2021

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

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7 January 2021

Targeting of O6-MeG DNA methyltransferase (MGMT) to mitochondria protects against alkylation induced cell death

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7 January 2021

In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions

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7 January 2021

Replication of mitochondrial DNA. Circular replicative intermediates in mouse L cells

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7 January 2021

The release of 5-methylene-2-furanone from irradiated DNA catalyzed by cationic polyamines and divalent metal cations

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7 January 2021

2-Deoxyribonolactone lesions in X-ray-irradiated DNA: quantitative determination by catalytic 5-methylene-2-furanone release

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7 January 2021

A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1

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7 January 2021

In vivo homologous recombination intermediates of yeast mitochondrial DNA analyzed by electron microscopy

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7 January 2021

Oxidative stress induces degradation of mitochondrial DNA

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7 January 2021

Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans

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7 January 2021

Significance of the dissociation of Dna2 by flap endonuclease 1 to Okazaki fragment processing in Saccharomyces cerevisiae

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7 January 2021

Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts

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7 January 2021

Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta

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7 January 2021

Long patch base excision repair in mammalian mitochondrial genomes

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7 January 2021

Differential subcellular localization of human MutY homolog (hMYH) and the functional activity of adenine:8-oxoguanine DNA glycosylase

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7 January 2021

Mitochondrial DNA mutations in human disease

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7 January 2021

Mammalian mitochondria possess homologous DNA recombination activity

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7 January 2021

Fission yeast Dna2 is required for generation of the telomeric single-strand overhang

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7 January 2021

An 8-oxo-guanine repair pathway coordinated by MUTYH glycosylase and DNA polymerase lambda

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7 January 2021

A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine

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7 January 2021

DNA repair, mitochondria, and neurodegeneration

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7 January 2021

Use of fluorescence sensors to determine that 2-deoxyribonolactone is the major alkali-labile deoxyribose lesion produced in oxidatively damaged DNA.

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7 January 2021

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress

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7 January 2021

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

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7 January 2021

Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication.

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7 January 2021

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

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7 January 2021

Endonuclease G is required for early embryogenesis and normal apoptosis in mice

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7 January 2021

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

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7 January 2021

Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

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7 January 2021

Retention of both parental mitochondrial DNA species in mouse-Chinese hamster somatic cell hybrids.

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7 January 2021

Identifiers

DOI

10.1002/EM.20576

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22 August 2017

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PubMed ID

20544882