(Q46793098)

English

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

scientific article published in April 2006

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16273081%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

MTH1, an oxidized purine nucleoside triphosphatase, protects the dopamine neurons from oxidative damage in nucleic acids caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16273081%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

0 references

Kosuke Kajitani

2

1 reference

Europe PubMed Central

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8 January 2020

Yusaku Nakabeppu

8

1 reference

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8 January 2020

author name string

H Yamaguchi

1

1 reference

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8 January 2020

Y Dan

3

1 reference

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8 January 2020

M Furuichi

4

1 reference

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8 January 2020

M Ohno

5

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8 January 2020

K Sakumi

6

1 reference

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8 January 2020

D Kang

7

1 reference

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8 January 2020

publication date

1 April 2006

1 reference

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8 January 2020

Cell Death & Differentiation

1 reference

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8 January 2020

13

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8 January 2020

4

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8 January 2020

551-563

1 reference

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8 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401788

0 references

Molecular genetics and structural biology of human MutT homolog, MTH1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

21 January 2018

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

21 January 2018

Oxidative damage is the earliest event in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

21 January 2018

The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative nucleotide damage: consequences and prevention

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative damage and mitochondrial decay in aging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of hMTH1 in the hippocampi of control and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of 1-methyl-4-phenylpyridinium ion (MPP+) and its analogs with the rotenone/piericidin binding site of NADH dehydrogenase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurochemical findings in the MPTP model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Biomarkers of OH radical damage in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Reactive oxygen species and the central nervous system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial dysfunction in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Melatonin protects against MPTP/MPP+ -induced mitochondrial DNA oxidative damage in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

1-methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson's disease mice model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

The inflammatory reaction following 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine intoxication in mouse.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinson's disease and related neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Human mitochondrial DNA is packaged with TFAM.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Human APE2 protein is mostly localized in the nuclei and to some extent in the mitochondria, while nuclear APE2 is partly associated with proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401788

7 January 2021

based on heuristic

inferred from DOI database lookup

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