(Q37769103)

22 August 2017

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title

Human papillomavirus oncoproteins: pathways to transformation (English)

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22 August 2017

Cary A Moody

1

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22 August 2017

Laimonis A Laimins

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

1 July 2010

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22 August 2017

Nature Reviews Cancer

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22 August 2017

10

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22 August 2017

550-560

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22 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc2886

22 August 2017

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cites work

Classification of papillomaviruses

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Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

31 March 2020

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Chapter 2: The burden of HPV-related cancers

31 March 2020

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Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins

31 March 2020

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Differentiation-dependent up-regulation of the human papillomavirus E7 gene reactivates cellular DNA replication in suprabasal differentiated keratinocytes

31 March 2020

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The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

31 March 2020

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Mechanisms of cell transformation by papillomavirus E5 proteins

31 March 2020

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31 March 2020

The Hallmarks of Cancer

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Papillomaviruses and cancer: from basic studies to clinical application

31 March 2020

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A comprehensive analysis of HPV integration loci in anogenital lesions combining transcript and genome-based amplification techniques.

31 March 2020

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Viral integration and fragile sites in human papillomavirus-immortalized human keratinocyte cell lines

31 March 2020

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Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

31 March 2020

1 reference

Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis

31 March 2020

1 reference

Repression of the integrated papillomavirus E6/E7 promoter is required for growth suppression of cervical cancer cells.

31 March 2020

1 reference

Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

31 March 2020

1 reference

Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses

31 March 2020

1 reference

Oncogenic activities of human papillomaviruses

31 March 2020

1 reference

The human papillomavirus E7 oncoprotein

31 March 2020

1 reference

Papillomavirus E6 proteins

31 March 2020

1 reference

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro

31 March 2020

1 reference

Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice

31 March 2020

1 reference

Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene

31 March 2020

1 reference

Cotransfection of HPV-18 and v-fos DNA induces tumorigenicity of primary human keratinocytes

31 March 2020

1 reference

The regulation of E2F by pRB-family proteins

31 March 2020

1 reference

Atypical E2Fs: new players in the E2F transcription factor family

31 March 2020

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Chromatin remodeling and Rb activity

31 March 2020

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A revised picture of the E2F transcriptional network and RB function

31 March 2020

1 reference

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product

31 March 2020

1 reference

Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner

31 March 2020

1 reference

The binding of histone deacetylases and the integrity of zinc finger-like motifs of the E7 protein are essential for the life cycle of human papillomavirus type 31.

31 March 2020

1 reference

The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth

31 March 2020

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Human papillomavirus type 16 E7 oncoprotein associates with E2F6.

31 March 2020

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Retinoblastoma protein recruits histone deacetylase to repress transcription

31 March 2020

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HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs

31 March 2020

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Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis

31 March 2020

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Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis

31 March 2020

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Cyclins and cdks in development and cancer: a perspective

31 March 2020

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The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2.

31 March 2020

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Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein

31 March 2020

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Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7.

31 March 2020

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Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes

31 March 2020

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Regulation of the Cdc25A gene by the human papillomavirus Type 16 E7 oncogene

31 March 2020

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Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest

31 March 2020

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Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases

31 March 2020

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Elevated wild-type p53 protein levels in human epithelial cell lines immortalized by the human papillomavirus type 16 E7 gene

31 March 2020

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Molecular pathways executing the "trophic sentinel" response in HPV-16 E7-expressing normal human diploid fibroblasts upon growth factor deprivation

31 March 2020

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

31 March 2020

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

31 March 2020

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Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein

31 March 2020

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The E6 protein of human papillomavirus type 16 binds to and inhibits co-activation by CBP and p300.

31 March 2020

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Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3

31 March 2020

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Viral oncoproteins discriminate between p53 and the p53 homolog p73.

31 March 2020

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Failure of viral oncoproteins to target the p53-homologue p51A

31 March 2020

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

31 March 2020

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Human papillomaviruses, cervical cancer and cell polarity

31 March 2020

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Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle

31 March 2020

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The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo

31 March 2020

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Telomeres and telomerase in cancer

31 March 2020

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Papillomavirus E6 and E7 proteins and their cellular targets

31 March 2020

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NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells

31 March 2020

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The human papillomavirus type 16 E6 and E7 oncoproteins dissociate cellular telomerase activity from the maintenance of telomere length

31 March 2020

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Telomere attrition predominantly occurs in precursor lesions during in vivo carcinogenic process of the uterine cervix.

31 March 2020

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HPV-16 E7 reveals a link between DNA replication stress, fanconi anemia D2 protein, and alternative lengthening of telomere-associated promyelocytic leukemia bodies

31 March 2020

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Human papillomavirus and cervical cancer

31 March 2020

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Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.

31 March 2020

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Immortalization of human cells and their malignant conversion by high risk human papillomavirus genotypes

31 March 2020

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DNA ploidy profiles as prognostic indicators in CIN lesions

31 March 2020

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Proliferation and DNA aneuploidy in mild dysplasia imply early steps of cervical carcinogenesis

31 March 2020

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Oncogenic human papillomaviruses and ploidy in cervical lesions

31 March 2020

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Centrosome overduplication, chromosomal instability, and human papillomavirus oncoproteins

31 March 2020

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Koilocytotic lesions of the cervix. The relationship of mitotic abnormalities to the presence of papillomavirus antigens and nuclear DNA content

31 March 2020

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The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

31 March 2020

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Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates

31 March 2020

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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

31 March 2020

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Human papillomavirus type 16 E7 oncoprotein can induce abnormal centrosome duplication through a mechanism independent of inactivation of retinoblastoma protein family members

31 March 2020

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Human papillomavirus type 16 E7 oncoprotein associates with the centrosomal component gamma-tubulin

31 March 2020

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Human papillomavirus type 16 E6 and E7 cause polyploidy in human keratinocytes and up-regulation of G2-M-phase proteins

31 March 2020

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The role of human papillomavirus oncoproteins E6 and E7 in apoptosis

31 March 2020

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The human papillomavirus-16 E6 oncoprotein decreases the vigilance of mitotic checkpoints.

31 March 2020

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Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation

31 March 2020

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Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin

31 March 2020

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DNA damage checkpoints: from initiation to recovery or adaptation

31 March 2020

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Human papillomavirus DNA and p53 polymorphisms in squamous cell carcinomas from Fanconi anemia patients.

31 March 2020

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The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells

31 March 2020

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Proliferation, cell cycle and apoptosis in cancer

31 March 2020

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Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification

31 March 2020

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Anoikis: a necessary death program for anchorage-dependent cells

31 March 2020

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Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18

31 March 2020

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The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

31 March 2020

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Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif

31 March 2020

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Interaction of oncogenic papillomavirus E6 proteins with fibulin-1

31 March 2020

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Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600

31 March 2020

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The cytokines tumor necrosis factor-alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the human papillomavirus-16 E7 oncoprotein

31 March 2020

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The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.

31 March 2020

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The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis.

31 March 2020

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Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis

31 March 2020

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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.

31 March 2020

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Human papillomaviruses and the interferon response

31 March 2020

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Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31.

31 March 2020

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Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

31 March 2020

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Inactivation of interferon regulatory factor-1 tumor suppressor protein by HPV E7 oncoprotein. Implication for the E7-mediated immune evasion mechanism in cervical carcinogenesis

31 March 2020

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The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-alpha.

31 March 2020

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Human papillomaviruses target the double-stranded RNA protein kinase pathway

31 March 2020

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Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death

31 March 2020

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Human papillomavirus E6 proteins mediate resistance to interferon-induced growth arrest through inhibition of p53 acetylation

31 March 2020

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Endoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH.

31 March 2020

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Codon optimization of the HPV-16 E5 gene enhances protein expression

31 March 2020

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The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression.

31 March 2020

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The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells

31 March 2020

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The E5 gene of HPV-16 enhances keratinocyte immortalization by full-length DNA.

31 March 2020

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Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis

31 March 2020

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A role for HPV16 E5 in cervical carcinogenesis

31 March 2020

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Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer.

31 March 2020

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Coexistence of episomal and integrated HPV16 DNA in squamous cell carcinoma of the cervix

31 March 2020

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Bap31 is a novel target of the human papillomavirus E5 protein

31 March 2020

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E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain

31 March 2020

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HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells

31 March 2020

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Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial

31 March 2020

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Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells

31 March 2020

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12 December 2020

Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells

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12 December 2020

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.

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12 December 2020

Human papillomavirus oncoproteins E6 and E7 independently abrogate the mitotic spindle checkpoint.

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12 December 2020

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region

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12 December 2020

Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype

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12 December 2020

Characterization of primary human keratinocytes transformed by human papillomavirus type 18.

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12 December 2020

Effect of human papillomavirus type 16 oncogenes on MAP kinase activity.

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12 December 2020

The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes

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12 December 2020

The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.

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12 December 2020

The expression of HPV-16 E5 protein in squamous neoplastic changes in the uterine cervix

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12 December 2020

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis.

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12 December 2020

Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein

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12 December 2020

The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction to the nucleus

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12 December 2020

Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein

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12 December 2020

E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

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12 December 2020

The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes

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12 December 2020

Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis

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12 December 2020

Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation

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12 December 2020

HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes

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12 December 2020

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18

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12 December 2020

The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV-6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties

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12 December 2020

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product

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12 December 2020

The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300.

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12 December 2020

Modulation of transcriptional regulatory properties of p53 by HPV E6.

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12 December 2020

Inhibition of p53 DNA binding by human papillomavirus E6 proteins

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12 December 2020

Differential requirements for conserved E2 binding sites in the life cycle of oncogenic human papillomavirus type 31

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12 December 2020

The human papillomavirus type 6 and 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein.

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12 December 2020

Expression of HPV16 E6 or E7 increases integration of foreign DNA.

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12 December 2020

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

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12 December 2020

Massively parallel sequencing analysis of 68 gastric-type cervical adenocarcinomas reveals mutations in cell cycle-related genes and potentially targetable mutations

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NRC2886

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release_4enimhzn7fhgzkqjdm3vuruhka

22 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4enimhzn7fhgzkqjdm3vuruhka

24 November 2022

mapped directly with Wikidata item

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