(Q37769761)

22 August 2017

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title

Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters (English)

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22 August 2017

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Josef M Penninger

4

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Takayo Ohto-Nakanishi

series ordinal

3

object named as

Takayo Ohto-Nakanishi

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22 August 2017

1

Keiji Kuba

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22 August 2017

Yumiko Imai

2

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22 August 2017

3 July 2010

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Pharmacology & Therapeutics

22 August 2017

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22 August 2017

128

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22 August 2017

1

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22 August 2017

119-128

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ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice.

22 August 2017

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12 December 2020

Angiotensin-converting enzyme 2 in the brain: properties and future directions

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12 December 2020

Essential role for collectrin in renal amino acid transport

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12 December 2020

Angiotensin II-generating enzymes

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12 December 2020

ACE2: a new target for cardiovascular disease therapeutics

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12 December 2020

Myocardial infarction increases ACE2 expression in rat and humans.

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12 December 2020

ACE2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR.

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12 December 2020

Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?

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12 December 2020

Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients

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12 December 2020

Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice

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12 December 2020

Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension

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12 December 2020

Immunolocalization of ACE2 and AT2 receptors in rabbit atherosclerotic plaques.

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12 December 2020

Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system

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12 December 2020

Angiotensin-converting enzyme 2 and angiotensin-(1-7): an evolving story in cardiovascular regulation.

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12 December 2020

Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

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12 December 2020

Selective and specific regulation of ectodomain shedding of angiotensin-converting enzyme 2 by tumor necrosis factor alpha-converting enzyme

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12 December 2020

The role of ACE2 in pulmonary diseases--relevance for the nephrologist

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12 December 2020

Angiotensin-(1-7): blood, heart, and blood vessels.

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12 December 2020

Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.

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12 December 2020

Kidney amino acid transport.

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12 December 2020

The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction

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12 December 2020

Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted

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12 December 2020

ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes

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12 December 2020

Angiotensin converting enzyme 2 is primarily epithelial and is developmentally regulated in the mouse lung

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12 December 2020

Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.

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12 December 2020

Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo

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12 December 2020

Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.

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12 December 2020

The tissue renin-angiotensin system and intracellular signalling

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12 December 2020

Calmodulin interacts with angiotensin-converting enzyme-2 (ACE2) and inhibits shedding of its ectodomain

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12 December 2020

Injections of angiotensin-converting enzyme 2 inhibitor MLN4760 into nucleus tractus solitarii reduce baroreceptor reflex sensitivity for heart rate control in rats

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12 December 2020

Human recombinant ACE2 reduces the progression of diabetic nephropathy

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12 December 2020

The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis

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12 December 2020

Peptidyl dipeptidase A: angiotensin I-converting enzyme.

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12 December 2020

Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys

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12 December 2020

The importance of the renin-angiotensin system in cardiovascular disease

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12 December 2020

Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome

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12 December 2020

The Biochemistry of the Renin-Angiotensin System

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12 December 2020

Angiotensin-converting enzyme 2 in lung diseases

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12 December 2020

Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats.

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12 December 2020

In vivo metabolism of angiotensin I by neutral endopeptidase (EC 3.4.24.11) in spontaneously hypertensive rats

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12 December 2020

Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus

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12 December 2020

The renin-angiotensin system: importance in physiology and pathology

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12 December 2020

Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase

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12 December 2020

Pathophysiology of acute lung injury and the acute respiratory distress syndrome

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12 December 2020

Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology

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12 December 2020

A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung.

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12 December 2020

Regulation of ACE2 in cardiac myocytes and fibroblasts

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12 December 2020

Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells

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12 December 2020

Clinical risks for development of the acute respiratory distress syndrome

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12 December 2020

Secretase-mediated cell surface shedding of the angiotensin-converting enzyme

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12 December 2020

Hereditary pellagra-like skin rash with temporary cerebellar ataxia, constant renal amino-aciduria, and other bizarre biochemical features

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12 December 2020

Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome.

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12 December 2020

Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors

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12 December 2020

ACE and ACE2 activity in diabetic mice.

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12 December 2020

Angiotensin-converting enzyme 2 is an essential regulator of heart function

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12 December 2020

Male–female differences in fertility and blood pressure in ACE-deficient mice

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12 December 2020

Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells

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12 December 2020

Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.

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12 December 2020

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

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12 December 2020

Angiotensin-converting enzyme: zinc- and inhibitor-binding stoichiometries of the somatic and testis isozymes

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12 December 2020

The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

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12 December 2020

Prolyl endopeptidase purified from granulomatous inflammation in mice.

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12 December 2020

Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice

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12 December 2020

Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction

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12 December 2020

Hartnup disorder is caused by mutations in the gene encoding the neutral amino acid transporter SLC6A19

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12 December 2020

Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.

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12 December 2020

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas

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12 December 2020

Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese

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12 December 2020

Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells

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12 December 2020

Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro

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12 December 2020

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.

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12 December 2020

The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism

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12 December 2020

Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats

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12 December 2020

Angiotensin-converting enzyme 2 and the kidney

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12 December 2020

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

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12 December 2020

Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats

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12 December 2020

ACE2 of the heart: From angiotensin I to angiotensin (1-7)

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12 December 2020

Angiotensin-converting enzyme 2 protects from severe acute lung failure.

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12 December 2020

Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China.

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12 December 2020

ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts.

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12 December 2020

Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry

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12 December 2020

Modification of the terminal residue of apelin-13 antagonizes its hypotensive action

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12 December 2020

Genetically altered animal models for Mas and angiotensin-(1-7).

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12 December 2020

Immunopathogenesis of coronavirus infections: implications for SARS.

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12 December 2020

SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway

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12 December 2020

Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women

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12 December 2020

Mutations in SLC6A19, encoding B0AT1, cause Hartnup disorder

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12 December 2020

NF-kappaB-dependent increase in intrarenal angiotensin II induced by proteinuria

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12 December 2020

Release of angiotensin-(1-7) from the rat hindlimb: influence of angiotensin-converting enzyme inhibition

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12 December 2020

The renin-angiotensin system.

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12 December 2020

Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men

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12 December 2020

Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins

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12 December 2020

Pathogenesis of severe acute respiratory syndrome

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12 December 2020

A protein complex in the brush-border membrane explains a Hartnup disorder allele.

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12 December 2020

Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin

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12 December 2020

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

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12 December 2020

Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease

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12 December 2020

The angiotensin-converting enzyme gene family: genomics and pharmacology

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12 December 2020

Molecular cloning, mRNA expression and chromosomal localization of mouse angiotensin-converting enzyme-related carboxypeptidase (mACE2).

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12 December 2020

Overexpression of ACE2 enhances plaque stability in a rabbit model of atherosclerosis

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12 December 2020

Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages

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12 December 2020

Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension

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12 December 2020

The preparation and function of the hypertensin-converting enzyme

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12 December 2020

The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2.

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12 December 2020

Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation

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12 December 2020

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor

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12 December 2020

Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.

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12 December 2020

Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.

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12 December 2020

Angiotensin converting enzyme 2 in the kidney.

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12 December 2020

Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.

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12 December 2020

Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.

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12 December 2020

Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.

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12 December 2020

Human coronavirus HCoV-229E enters susceptible cells via the endocytic pathway

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12 December 2020

Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls

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12 December 2020

ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis

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12 December 2020

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

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12 December 2020

Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis

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12 December 2020

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

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12 December 2020

Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line

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12 December 2020

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury

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12 December 2020

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

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12 December 2020

Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence

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12 December 2020

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor

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12 December 2020

The severe acute respiratory syndrome

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12 December 2020

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

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12 December 2020

Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion

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12 December 2020

The role for HNF-1beta-targeted collectrin in maintenance of primary cilia and cell polarity in collecting duct cells

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12 December 2020

Novel peptide inhibitors of angiotensin-converting enzyme 2.

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12 December 2020

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload

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12 December 2020

Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II.

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12 December 2020

Effectively targetting the renin-angiotensin-aldosterone system in cardiovascular and renal disease: rationale for using angiotensin II receptor blockers in combination with angiotensin-converting enzyme inhibitors

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12 December 2020

Role of HIF-1alpha in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells

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12 December 2020

Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury

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12 December 2020

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

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12 December 2020

Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice.

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12 December 2020

The Genome sequence of the SARS-associated coronavirus

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12 December 2020

Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors

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12 December 2020

Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity

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12 December 2020

Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning

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12 December 2020

Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2.

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12 December 2020

Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.

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12 December 2020

Polymorphism of the angiotensin-converting enzyme gene affects the outcome of acute respiratory distress syndrome

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12 December 2020

Differential downregulation of ACE2 by the spike proteins of severe acute respiratory syndrome coronavirus and human coronavirus NL63.

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12 December 2020

10.1016/J.PHARMTHERA.2010.06.003

Identifiers

DOI

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22 August 2017

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PubMed ID

20599443