(Q37770435)

22 August 2017

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title

Coordination of chondrogenesis and osteogenesis by hypertrophic chondrocytes in endochondral bone development (English)

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22 August 2017

main subject

cartilage development

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inferred from title

hypertrophic chondrocyte

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Hironori Hojo

1

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22 August 2017

Shinsuke Ohba

series ordinal

2

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22 August 2017

Fumiko Yano

series ordinal

3

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22 August 2017

Ung-il Chung

series ordinal

4

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22 August 2017

publication date

6 July 2010

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Journal of Bone and Mineral Metabolism

22 August 2017

published in

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22 August 2017

volume

28

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22 August 2017

issue

5

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22 August 2017

page(s)

489-502

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https://scigraph.springernature.com/pub.10.1007/s00774-010-0199-7

22 August 2017

exact match

0 references

cites work

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Sequential roles of Hedgehog and Wnt signaling in osteoblast development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00774-010-0199-7

Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3.

21 January 2018

1 reference

12 December 2020

A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling

1 reference

12 December 2020

S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes

1 reference

12 December 2020

Dimorphic effects of Notch signaling in bone homeostasis.

1 reference

12 December 2020

Mechanisms of Wnt signaling in development

1 reference

12 December 2020

NFAT and Osterix cooperatively regulate bone formation

1 reference

12 December 2020

The Notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells

1 reference

12 December 2020

Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure

1 reference

12 December 2020

PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps.

1 reference

12 December 2020

1 reference

12 December 2020

Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation

1 reference

12 December 2020

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

1 reference

12 December 2020

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

1 reference

12 December 2020

The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage

1 reference

12 December 2020

A twist code determines the onset of osteoblast differentiation

1 reference

12 December 2020

Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.

1 reference

12 December 2020

Regulation of osteoblastogenesis and bone mass by Wnt10b

1 reference

12 December 2020

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

1 reference

12 December 2020

Mutations of the TWIST gene in the Saethre-Chotzen syndrome

1 reference

12 December 2020

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

1 reference

12 December 2020

New aspects of Wnt signaling pathways in higher vertebrates

1 reference

12 December 2020

Sox9 is required for cartilage formation

1 reference

12 December 2020

Smad transcription factors

1 reference

12 December 2020

Induction of osteogenic differentiation by hedgehog proteins.

1 reference

12 December 2020

Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures

1 reference

12 December 2020

Cbfbeta interacts with Runx2 and has a critical role in bone development

1 reference

12 December 2020

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

1 reference

12 December 2020

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide

1 reference

12 December 2020

Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling

1 reference

12 December 2020

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

1 reference

12 December 2020

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

1 reference

12 December 2020

Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling

1 reference

12 December 2020

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway

1 reference

12 December 2020

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

1 reference

12 December 2020

BMP signaling in the cartilage growth plate.

1 reference

12 December 2020

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

1 reference

12 December 2020

Correlation between ALK-6 (BMPR-IB) distribution and responsiveness to osteogenic protein-1 (BMP-7) in embryonic mouse bone rudiments

1 reference

12 December 2020

Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3

1 reference

12 December 2020

An LDL-receptor-related protein mediates Wnt signalling in mice

1 reference

12 December 2020

HDAC4 represses vascular endothelial growth factor expression in chondrosarcoma by modulating RUNX2 activity

1 reference

12 December 2020

Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

1 reference

12 December 2020

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

1 reference

12 December 2020

Osteoblastic cells regulate the haematopoietic stem cell niche

1 reference

12 December 2020

1 reference

12 December 2020

Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation

1 reference

12 December 2020

The type I BMP receptor BmprIB is essential for female reproductive function

1 reference

12 December 2020

Non-Smad TGF-beta signals

1 reference

12 December 2020

The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin

1 reference

12 December 2020

Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome

1 reference

12 December 2020

The Wnt antagonist Frzb-1 regulates chondrocyte maturation and long bone development during limb skeletogenesis

1 reference

12 December 2020

Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro

1 reference

12 December 2020

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1 reference

12 December 2020

E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

1 reference

12 December 2020

Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo.

1 reference

12 December 2020

Expression of FGFR3 with the G380R achondroplasia mutation inhibits proliferation and maturation of CFK2 chondrocytic cells

1 reference

12 December 2020

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

1 reference

12 December 2020

Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

1 reference

12 December 2020

Notch inhibits osteoblast differentiation and causes osteopenia

1 reference

12 December 2020

DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway

1 reference

12 December 2020

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells

1 reference

12 December 2020

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

1 reference

12 December 2020

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

12 December 2020

Novel regulators of bone formation: molecular clones and activities

1 reference

12 December 2020

Hedgehog signaling in animal development: paradigms and principles

1 reference

12 December 2020

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

1 reference

12 December 2020

A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

1 reference

12 December 2020

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for bone morphogenetic protein-2A (BMP-2A)

1 reference

12 December 2020

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation

1 reference

12 December 2020

Identification of the haematopoietic stem cell niche and control of the niche size

1 reference

12 December 2020

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

1 reference

12 December 2020

Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes

1 reference

12 December 2020

Identification of a potent combination of osteogenic genes for bone regeneration using embryonic stem (ES) cell-based sensor

1 reference

12 December 2020

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

1 reference

12 December 2020

Notch 1 impairs osteoblastic cell differentiation

1 reference

12 December 2020

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

12 December 2020

FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate

1 reference

12 December 2020

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6

1 reference

12 December 2020

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation

1 reference

12 December 2020

Runx2, a multifunctional transcription factor in skeletal development

1 reference

12 December 2020

Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice

1 reference

12 December 2020

The shortest path from the surface to the nucleus: RBP-J kappa/Su(H) transcription factor

1 reference

12 December 2020

Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity

1 reference

12 December 2020

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

1 reference

12 December 2020

TGF-beta signal transduction

1 reference

12 December 2020

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

1 reference

12 December 2020

The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice

1 reference

12 December 2020

Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling

1 reference

12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

12 December 2020

Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development

1 reference

12 December 2020

Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts.

1 reference

12 December 2020

The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation

1 reference

12 December 2020

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

1 reference

12 December 2020

Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.

1 reference

12 December 2020

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis

1 reference

12 December 2020

FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

1 reference

12 December 2020

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

12 December 2020

The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C

1 reference

12 December 2020

BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

1 reference

12 December 2020

High bone density due to a mutation in LDL-receptor-related protein 5

1 reference

12 December 2020

Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification

1 reference

12 December 2020

Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.

1 reference

12 December 2020

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

1 reference

12 December 2020

Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

1 reference

12 December 2020

Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development

1 reference

12 December 2020

BMP-6 is an autocrine stimulator of chondrocyte differentiation

1 reference

12 December 2020

The mammalian basic helix loop helix protein HES-1 binds to and modulates the transactivating function of the runt-related factor Cbfa1

1 reference

12 December 2020

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage

1 reference

12 December 2020

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis

1 reference

12 December 2020

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

1 reference

12 December 2020

Bone morphogenetic proteins and their antagonists

1 reference

12 December 2020

1 reference

12 December 2020

Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

1 reference

12 December 2020

Stimulation of osteoblastic cell differentiation by Notch

1 reference

12 December 2020

Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.

1 reference

12 December 2020

Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

1 reference

12 December 2020

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

1 reference

12 December 2020

Bone morphogenetic protein-3 is a negative regulator of bone density

1 reference

12 December 2020

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

1 reference

12 December 2020

BMP signaling stimulates cellular differentiation at multiple steps during cartilage development

1 reference

12 December 2020

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

1 reference

12 December 2020

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

1 reference

12 December 2020

A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development

1 reference

12 December 2020

Core-binding factor beta interacts with Runx2 and is required for skeletal development

1 reference

12 December 2020

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

1 reference

12 December 2020

Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development

1 reference

12 December 2020

Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor beta (TGF-beta) on endochondral bone formation

1 reference

12 December 2020

Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling

1 reference

12 December 2020

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation

1 reference

12 December 2020

GSK-3beta controls osteogenesis through regulating Runx2 activity

1 reference

12 December 2020

High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage

1 reference

12 December 2020

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation

1 reference

12 December 2020

Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene

1 reference

12 December 2020

Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development.

1 reference

12 December 2020

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

1 reference

12 December 2020

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

12 December 2020

FGF signaling in the developing endochondral skeleton

1 reference

12 December 2020

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

1 reference

12 December 2020

Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes

1 reference

12 December 2020

Developmental regulation of the growth plate

1 reference

12 December 2020

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene

1 reference

12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

12 December 2020

Transforming growth factor-beta in calf articular cartilage organ cultures: synthesis and distribution

1 reference

12 December 2020

Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development.

1 reference

12 December 2020

Coordinated activation of notch, Wnt, and transforming growth factor-beta signaling pathways in bone morphogenic protein 2-induced osteogenesis. Notch target gene Hey1 inhibits mineralization and Runx2 transcriptional activity

1 reference

12 December 2020

The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation

1 reference

12 December 2020

10.1007/S00774-010-0199-7

Identifiers

DOI

1 reference

22 August 2017

1 reference