(Q37774374)

23 August 2017

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title

17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review (English)

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23 August 2017

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Donald Poirier

1

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23 August 2017

language of work or name

English

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publication date

1 September 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

published in

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23 August 2017

volume

20

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23 August 2017

issue

9

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23 August 2017

page(s)

1123-1145

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Sex, sex steroids, and brain injury

23 August 2017

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New development in intracrinology of breast carcinoma

21 January 2018

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Androgen receptor antagonists (antiandrogens): structure-activity relationships

21 January 2018

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Glucocorticoid receptor antagonists: new tools to investigate disorders characterized by cortisol hypersecretion

21 January 2018

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Structure-function relationships in the mineralocorticoid receptor

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Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents

21 January 2018

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Selective androgen receptor modulators as function promoting therapies

21 January 2018

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Crystallogenesis of Steroid-Converting Enzymes and Their Complexes: Enzyme–Ligand Interaction Studies and Inhibitor Design Facilitated by Complex Structures†

21 January 2018

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Androgen biosynthetic pathways in the human prostate

21 January 2018

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Integrated view on 17beta-hydroxysteroid dehydrogenases

21 January 2018

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17beta-hydroxysteroid dehydrogenases in human breast cancer

21 January 2018

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Structure and function of human 17beta-hydroxysteroid dehydrogenases

21 January 2018

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The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology

21 January 2018

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Localization of type 5 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization

21 January 2018

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Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies

21 January 2018

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Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization

21 January 2018

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Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12

21 January 2018

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Characteristics of human types 1, 2 and 3 17 beta-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition

21 January 2018

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Human 17 beta-hydroxysteroid dehydrogenase type 1 and type 2 isoenzymes have opposite activities in cultured cells and characteristic cell- and tissue-specific expression

21 January 2018

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Relative involvement of three 17beta-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors

21 January 2018

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Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study

21 January 2018

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A guide to 17beta-hydroxysteroid dehydrogenases

21 January 2018

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Pre-receptor steroid metabolism as target for pharmacological treatment.

21 January 2018

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17beta-hydroxysteroid dehydrogenase Type 1, and not Type 12, is a target for endocrine therapy of hormone-dependent breast cancer.

21 January 2018

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Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease

21 January 2018

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Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase

21 January 2018

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Perspectives in understanding the role of human 17beta-hydroxysteroid dehydrogenases in health and disease.

21 January 2018

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17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

21 January 2018

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Control of cell proliferation by steroids: the role of 17HSDs

21 January 2018

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Design and validation of specific inhibitors of 17beta-hydroxysteroid dehydrogenases for therapeutic application in breast and prostate cancer, and in endometriosis

21 January 2018

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Cutaneous androgen metabolism: basic research and clinical perspectives

21 January 2018

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Overview of a rational approach to design type I 17beta-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation

21 January 2018

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Inhibitors of type II 17beta-hydroxysteroid dehydrogenase

21 January 2018

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Inhibitors of 17 beta-hydroxysteroid dehydrogenases

21 January 2018

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Advances in development of inhibitors of 17beta hydroxysteroid dehydrogenases

21 January 2018

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Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

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Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives

21 January 2018

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Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase

21 January 2018

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Inhibition of type 2 17beta-hydroxysteroid dehydrogenase by estradiol derivatives bearing a lactone on the D-ring: structure-activity relationships

21 January 2018

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Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities

21 January 2018

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 2. SAR.

21 January 2018

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4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate

21 January 2018

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Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors

21 January 2018

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Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

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E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

The design of novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Development of hormone-dependent prostate cancer models for the evaluation of inhibitors of 17beta-hydroxysteroid dehydrogenase type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Evaluation of inhibitors for 17beta-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Identification of novel functional inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent d

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Structure-activity study in the class of 6-(3'-hydroxyphenyl)naphthalenes leading to an optimization of a pharmacophore model for 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

New insights into the SAR and binding modes of bis(hydroxyphenyl)thiophenes and -benzenes: influence of additional substituents on 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitory activity and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-Hydroxysteroid Dehydrogenase (17beta-HSD) type 1 and type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

Enzymatic Formation of 3α-Hydroxysteroids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.505604

10.1517/13543776.2010.505604

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

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