(Q33253063)

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Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

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scholarly article

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Europe PubMed Central

24 July 2017

Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1. (English)

1 reference

Europe PubMed Central

24 July 2017

11

object named as

Barry V L Potter

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Europe PubMed Central

24 July 2017

author name string

Nigel Vicker

1

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Europe PubMed Central

24 July 2017

Harshani R Lawrence

2

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Europe PubMed Central

24 July 2017

Gillian M Allan

3

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Europe PubMed Central

24 July 2017

Christian Bubert

4

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Europe PubMed Central

24 July 2017

Andrew Smith

5

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Europe PubMed Central

24 July 2017

Helena J Tutill

6

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Europe PubMed Central

24 July 2017

Atul Purohit

7

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Europe PubMed Central

24 July 2017

Joanna M Day

8

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24 July 2017

Mary F Mahon

9

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Europe PubMed Central

24 July 2017

Michael J Reed

10

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24 July 2017

publication date

1 April 2006

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Europe PubMed Central

24 July 2017

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Europe PubMed Central

24 July 2017

1

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Europe PubMed Central

24 July 2017

4

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Europe PubMed Central

24 July 2017

464-481

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Europe PubMed Central

24 July 2017

Inhibitors of 17 beta-hydroxysteroid dehydrogenases

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21 January 2018

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Inhibitors of steroidogenesis as agents for the treatment of hormone-dependent cancers

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Biological rationale for endocrine therapy in breast cancer

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Oestrogen suppression--lessons from clinical studies

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Steroid sulfatase: molecular biology, regulation, and inhibition.

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Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies

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The conversion of androstenedione to oestrone and production of oestrone in women with endometrial cancer

1 reference

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Plasma Precursors of Estrogen. II. Correlation of the Extent of Conversion of Plasma Androstenedione to Estrone with Age1

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Effects of aging and obesity on aromatase activity of human adipose cells

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Role of 17 beta-hydroxysteroid dehydrogenases in sex steroid formation in peripheral intracrine tissues

1 reference

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Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease

1 reference

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17beta-hydroxysteroid dehydrogenase (HSD)/17-ketosteroid reductase (KSR) family; nomenclature and main characteristics of the 17HSD/KSR enzymes

1 reference

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7 January 2021

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Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones

1 reference

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7 January 2021

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Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase

1 reference

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A guide to 17beta-hydroxysteroid dehydrogenases

1 reference

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The role of 17 beta-hydroxysteroid dehydrogenases.

1 reference

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7 January 2021

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Origin of substrate specificity of human and rat 17beta-hydroxysteroid dehydrogenase type 1, using chimeric enzymes and site-directed substitutions

1 reference

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7 January 2021

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Human Estrogenic 17β-Hydroxysteroid Dehydrogenase: Predominance of Estrone Reduction and Its Induction by NADPH

1 reference

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Activity and gene expression of 17β-hydroxysteroid dehydrogenase type I in primary cultures of epithelial and stromal cells derived from normal and tumourous human breast tissue: the role of IL-8

1 reference

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7 January 2021

based on heuristic

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Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

based on heuristic

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Short-chain dehydrogenases/reductases (SDR)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

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Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions

1 reference

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7 January 2021

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Short-chain dehydrogenases/reductases (SDR): the 2002 update

1 reference

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7 January 2021

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Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA.

1 reference

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7 January 2021

based on heuristic

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Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

based on heuristic

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The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

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Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol

1 reference

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7 January 2021

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Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

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Synthesis of a First Estradiol-Adenosine Hybrid Compound

1 reference

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A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

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Novel and potent 17beta-hydroxysteroid dehydrogenase type 1 inhibitors

1 reference

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E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200500087

7 January 2021

based on heuristic

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Modification of estrone at the 6, 16, and 17 positions: novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1.

1 reference

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7 January 2021

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Reactions of solid-supported reagents and solid supports with alcohols and phenols through their hydroxyl functional group.

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Comprehensive survey of combinatorial library synthesis: 2001.

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Steroids and combinatorial chemistry

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Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker

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A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives

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Overview of a rational approach to design type I 17beta-hydroxysteroid dehydrogenase inhibitors without estrogenic activity: chemical synthesis and biological evaluation

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Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs

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Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

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Development and validation of a genetic algorithm for flexible docking

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Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.

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The sulfamate functional group as a new anchor for solid-phase organic synthesis

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Estradiol-16alpha-carboxylic acid esters as locally active estrogens

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Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates

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Phase annealing in SHELX-90: direct methods for larger structures

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The role and proposed mechanism by which oestradiol 17 beta-hydroxysteroid dehydrogenase regulates breast tumour oestrogen concentrations

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Identifiers

10.1002/CMDC.200500087

1 reference

Europe PubMed Central

24 July 2017

1 reference

Europe PubMed Central

24 July 2017

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