(Q37779428)

23 August 2017

1 reference

title

Parkinson's disease: mitochondrial molecular pathology, inflammation, statins, and therapeutic neuroprotective nutrition (English)

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23 August 2017

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Richard Kones

1

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23 August 2017

publication date

1 August 2010

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Nutrition in Clinical Practice

23 August 2017

published in

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23 August 2017

volume

25

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23 August 2017

issue

4

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23 August 2017

page(s)

371-389

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Progressive dopamine neuron loss in Parkinson's disease: the multiple hit hypothesis

23 August 2017

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Searching for a relationship between manganese and welding and Parkinson's disease

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Dietary iron intake and risk of Parkinson's disease

21 January 2018

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 January 2018

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21 January 2018

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mtDNA clock runs out for dopaminergic neurons.

21 January 2018

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Inflammation as a causative factor in the aetiology of Parkinson's disease

21 January 2018

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Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention

21 January 2018

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Therapeutic approaches to inflammation in neurodegenerative disease

21 January 2018

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The role of microglia in paraquat-induced dopaminergic neurotoxicity

21 January 2018

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Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

21 January 2018

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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

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Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death.

21 January 2018

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Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover

21 January 2018

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https://api.crossref.org/works/10.1177%2F0884533610373932

Dietary factors in Parkinson's disease: the role of food groups and specific foods

21 January 2018

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Dietary fat intake and risk of Parkinson's disease: a case-control study in Japan.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0884533610373932

A balanced carbohydrate: protein diet in the management of Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F0884533610373932

Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes.

21 January 2018

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Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

21 January 2018

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Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes

21 January 2018

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Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0884533610373932

Inhibition of catechol-O-methyltransferase contributes to more stable levodopa plasma levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Computational systems analysis of dopamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Duodenal levodopa infusion monotherapy vs oral polypharmacy in advanced Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Dopamine transporter relation to dopamine turnover in Parkinson's disease: a positron emission tomography study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Levodopa for the treatment of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Amount and distribution of dietary protein affects clinical response to levodopa in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Interaction between levodopa and enteral nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Optimizing protein intake in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Calcium and vitamin D in the prevention of osteoporotic fractures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Increasing dietary protein requirements in elderly people for optimal muscle and bone health

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Potential application of essential amino Acid supplementation to treat sarcopenia in elderly people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Dietary protein and calcium interact to influence calcium retention: a controlled feeding study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effects of resistance exercise with and without creatine supplementation on gene expression and cell signaling in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Improved reperfusion and neuroprotection by creatine in a mouse model of stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Direct antioxidant properties of creatine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Mitochondrial creatine kinase in human health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

A randomized, double-blind, futility clinical trial of creatine and minocycline in early Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

21 January 2018

Mitochondrial disease

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Parkinson's disease, pesticides and mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Coenzyme Q10 attenuates the 1-methyl-4-phenyl-1,2,3,tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Practice Parameter: Neuroprotective strategies and alternative therapies for Parkinson disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Ascorbic acid stimulates DOPA synthesis and tyrosine hydroxylase gene expression in the human neuroblastoma cell line SK-N-SH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Immunomodulation by omega-3 fatty acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Modulation of lipid rafts by Omega-3 fatty acids in inflammation and cancer: implications for use of lipids during nutrition support

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Basic mechanisms behind the effects of n-3 fatty acids on cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Dietary intakes of fat and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

DNA damage in brain mitochondria caused by aging and MPTP treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Novel metabolism of docosahexaenoic acid in neural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effect of docosahexaenoic acid on membrane fluidity and function in intact cultured Y-79 retinoblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Modulation of native T-type calcium channels by omega-3 fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

'Rejuvenation' protects neurons in mouse models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Docosahexaenoic acid and the aging brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Docosahexaenoic acid: measurements in food and dietary exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Omega-3 fatty acids, energy substrates, and brain function during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Body composition in advanced-stage Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Vitamin d and rehabilitation: improving functional outcomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

A higher dose of vitamin d reduces the risk of falls in nursing home residents: a randomized, multiple-dose study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Recent developments in vitamin D deficiency and muscle weakness among elderly people

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Cholesterol homeostasis and function in neurons of the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Total cholesterol and the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Hypertension, hypercholesterolemia, diabetes, and risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Lower low-density lipoprotein cholesterol levels are associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Decreased cholesterol biosynthesis in fibroblasts from patients with Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Statin use and the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Use of statins and the risk of Parkinson's disease: a retrospective case-control study in the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Statins, cholesterol, Co-enzyme Q10, and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Total cholesterol and the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are able to reduce superoxide anion production by NADPH oxidase in THP-1-derived monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Neuroprotective autoimmunity: naturally occurring CD4+CD25+ regulatory T cells suppress the ability to withstand injury to the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Family history of melanoma and Parkinson disease risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Dolichol is the major lipid component of human substantia nigra neuromelanin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Signaling in muscle atrophy and hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Abrogation of insulin-like growth factor-I (IGF-I) and insulin action by mevalonic acid depletion: synergy between protein prenylation and receptor glycosylation pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

The Jupiter study, CRP screening, and aggressive statin therapy-implications for the primary prevention of cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Hypothalamic digoxin--central role in conscious perception, neuroimmunoendocrine integration and coordination of cellular function--relation to hemispheric dominance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Frequency of bowel movements and the future risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Association of coffee and caffeine intake with the risk of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Caffeine, postmenopausal estrogen, and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Is there a connection between estrogen and Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Coffee consumption, gender, and Parkinson's disease mortality in the cancer prevention study II cohort: the modifying effects of estrogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Parkinson's disease and tea: a quantitative review

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Potential therapeutic properties of green tea polyphenols in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effects of green tea polyphenols on dopamine uptake and on MPP+ -induced dopamine neuron injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

(-)-Epigallocatechin gallate regulates dopamine transporter internalization via protein kinase C-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Mucuna pruriens in Parkinson's disease: a double blind clinical and pharmacological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Neuroprotective effects of the antiparkinson drug Mucuna pruriens

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Case of neuroleptic malignant-like syndrome precipitated by abrupt fava bean discontinuance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Levodopa/dopamine replacement strategies in Parkinson's disease--future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Recreational physical activity and risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Effect of physical exercise on mortality in patients with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

The effectiveness of exercise interventions for people with Parkinson's disease: A systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Forced, not voluntary, exercise improves motor function in Parkinson's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Serum Cholesterol Levels and the Risk of Parkinson's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Oral administration of creatine monohydrate retards progression of motor neuron disease in the wobbler mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

Active Transport of L-Dopa in the Intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0884533610373932

21 January 2018

Identifiers

DOI

10.1177/0884533610373932

1 reference

23 August 2017

1 reference