(Q37780015)

23 August 2017

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title

Aflibercept (VEGF Trap): one more double-edged sword of anti-VEGF therapy for cancer? (English)

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23 August 2017

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Ketao Jin

1

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23 August 2017

Yanping Shen

2

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23 August 2017

Kuifeng He

3

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23 August 2017

Zhenzhen Xu

4

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23 August 2017

Guangliang Li

5

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23 August 2017

Lisong Teng

6

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23 August 2017

publication date

1 August 2010

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Clinical and Translational Oncology

23 August 2017

published in

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23 August 2017

volume

12

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23 August 2017

issue

8

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23 August 2017

page(s)

526-532

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https://scigraph.springernature.com/pub.10.1007/s12094-010-0550-4

23 August 2017

exact match

0 references

cites work

Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts

1 reference

https://api.crossref.org/works/10.1007%2FS12094-010-0550-4

Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-010-0550-4

VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-010-0550-4

Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-010-0550-4

Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-010-0550-4

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12094-010-0550-4

Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis

21 January 2018

1 reference

12 December 2020

VEGF Trap induces antiglioma effect at different stages of disease

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12 December 2020

Bevacizumab, bleeding, thrombosis, and warfarin

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12 December 2020

VEGF-Trap: a VEGF blocker with potent antitumor effects

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12 December 2020

Polycythemia vera: myths, mechanisms, and management

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12 December 2020

Sustained VEGF blockade results in microenvironmental sequestration of VEGF by tumors and persistent VEGF receptor-2 activation

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12 December 2020

Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors.

1 reference

12 December 2020

Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2.

1 reference

12 December 2020

Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma

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12 December 2020

Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap

1 reference

12 December 2020

A study of VEGF and its receptors in two rat models of proteinuria

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12 December 2020

Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies

1 reference

12 December 2020

TNP-470 promotes initial vascular sprouting in xenograft tumors

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12 December 2020

VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis.

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12 December 2020

VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells

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12 December 2020

The role of vascular endothelial growth factor (VEGF) in renal pathophysiology

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12 December 2020

Neutralization of Circulating Vascular Endothelial Growth Factor (VEGF) by Anti-VEGF Antibodies and Soluble VEGF Receptor 1 (sFlt-1) Induces Proteinuria

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12 December 2020

Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines

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12 December 2020

Vascular endothelial growth factor: a therapeutic target for tumors of the Ewing's sarcoma family

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12 December 2020

Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model

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12 December 2020

Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling

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12 December 2020

Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model

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12 December 2020

Signaling mechanisms mediating vascular protective actions of vascular endothelial growth factor

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12 December 2020

Effects of potent VEGF blockade on experimental Wilms tumor and its persisting vasculature.

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12 December 2020

Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors

1 reference

12 December 2020

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

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12 December 2020

VEGF signalling inhibition-induced proteinuria: Mechanisms, significance and management

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12 December 2020

VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature

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12 December 2020

Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model

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12 December 2020

Regression of established tumors and metastases by potent vascular endothelial growth factor blockade

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12 December 2020

10.1007/S12094-010-0550-4

Identifiers

DOI

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23 August 2017

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