(Q37780481)

23 August 2017

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title

Transgenic mouse models of multiple sclerosis (English)

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23 August 2017

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Tanja Scheikl

1

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23 August 2017

Béatrice Pignolet

series ordinal

2

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23 August 2017

Lennart T Mars

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3

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23 August 2017

Roland S Liblau

series ordinal

4

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23 August 2017

publication date

17 August 2010

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Cellular and Molecular Life Sciences

23 August 2017

published in

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23 August 2017

volume

67

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23 August 2017

issue

23

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23 August 2017

page(s)

4011-4034

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Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Cutting edge: Multiple sclerosis-like lesions induced by effector CD8 T cells recognizing a sequestered antigen on oligodendrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Temporal development of autoreactive Th1 responses and endogenous presentation of self myelin epitopes by central nervous system-resident APCs in Theiler's virus-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

A virus-induced molecular mimicry model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

CXCL10 (IFN-gamma-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Expression of the beta-chemokines RANTES and MIP-1 beta by human brain microvessel endothelial cells in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0481-9

Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes.

21 January 2018

1 reference

12 December 2020

Expression of monocyte chemoattractant protein-1 in brain tissue of patients with intractable epilepsy.

1 reference

12 December 2020

Negative feedback between prostaglandin and alpha- and beta-chemokine synthesis in human microglial cells and astrocytes

1 reference

12 December 2020

Major histocompatibility complex class I expression in oligodendrocytes induces hypomyelination in transgenic mice

1 reference

12 December 2020

Heteroclitic proliferative responses and changes in cytokine profile induced by altered peptides: implications for autoimmunity

1 reference

12 December 2020

Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

1 reference

12 December 2020

Autoreactive CD8 T cells in organ-specific autoimmunity: emerging targets for therapeutic intervention.

1 reference

12 December 2020

Targeted CNS expression of interferon-gamma in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development

1 reference

12 December 2020

Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Abrogation of resistance to Theiler's virus-induced demyelination in H-2b mice deficient in beta 2-microglobulin

1 reference

12 December 2020

Theiler's virus and Mengo virus induce cross-reactive cytotoxic T lymphocytes restricted to the same immunodominant VP2 epitope in C57BL/6 mice

1 reference

12 December 2020

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes

1 reference

12 December 2020

Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperation.

1 reference

12 December 2020

Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease

1 reference

12 December 2020

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.

1 reference

12 December 2020

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

1 reference

12 December 2020

Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue

1 reference

12 December 2020

HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis

1 reference

12 December 2020

Primary demyelination in transgenic mice expressing interferon-gamma

1 reference

12 December 2020

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

1 reference

12 December 2020

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage

1 reference

12 December 2020

SPONTANEOUS ENCEPHALOMYELITIS OF MICE, A NEW VIRUS DISEASE

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12 December 2020

Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

1 reference

12 December 2020

Multiple sclerosis - candidate mechanisms underlying CNS atrophy

1 reference

12 December 2020

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

1 reference

12 December 2020

Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

1 reference

12 December 2020

Resistance to herpes stromal keratitis conferred by an lgG2a-derived peptide

1 reference

12 December 2020

Antiviral immune responses: triggers of or triggered by autoimmunity?

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12 December 2020

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

1 reference

12 December 2020

Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis.

1 reference

12 December 2020

Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegeneration.

1 reference

12 December 2020

Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice

1 reference

12 December 2020

B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions

1 reference

12 December 2020

Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis

1 reference

12 December 2020

IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

1 reference

12 December 2020

Fulminant spontaneous autoimmunity of the central nervous system in mice transgenic for the myelin proteolipid protein-specific T cell receptor

1 reference

12 December 2020

Distinct patterns of stimulus-inducible chemokine mRNA accumulation in human fetal astrocytes and microglia

1 reference

12 December 2020

Autoimmune T cell responses in the central nervous system

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12 December 2020

Myelin-specific T cells also recognize neuronal autoantigen in a transgenic mouse model of multiple sclerosis

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12 December 2020

Molecular recognition and the future of monoclonal antibodies

1 reference

12 December 2020

Fine specificity of CD4+ T cell responses to the dominant encephalitogenic PLP 139-151 peptide in SJL/J mice

1 reference

12 December 2020

Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.

1 reference

12 December 2020

Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases.

1 reference

12 December 2020

Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis

1 reference

12 December 2020

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

1 reference

12 December 2020

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event

1 reference

12 December 2020

Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity

1 reference

12 December 2020

Central nervous system inflammation and neurological disease in transgenic mice expressing the CC chemokine CCL21 in oligodendrocytes

1 reference

12 December 2020

Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6

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12 December 2020

CCL2 transgene expression in the central nervous system directs diffuse infiltration of CD45(high)CD11b(+) monocytes and enhanced Theiler's murine encephalomyelitis virus-induced demyelinating disease

1 reference

12 December 2020

A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells.

1 reference

12 December 2020

Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens

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12 December 2020

Theiler's virus infection: a model for multiple sclerosis

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12 December 2020

Theiler's virus infection of the mouse, or: of the importance of studying animal models

1 reference

12 December 2020

CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'.

1 reference

12 December 2020

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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12 December 2020

Multiple sclerosis and viruses

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12 December 2020

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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12 December 2020

Myelin proteolipid protein-induced Th1 and Th2 clones express TCR with similar fine specificity for peptide and CDR3 homology despite diverse V beta usage

1 reference

12 December 2020

Constitutive expression of a costimulatory ligand on antigen-presenting cells in the nervous system drives demyelinating disease

1 reference

12 December 2020

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein

1 reference

12 December 2020

Expression of beta-chemokines and chemokine receptors in human fetal astrocyte and microglial co-cultures: potential role of chemokines in the developing CNS.

1 reference

12 December 2020

Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion

1 reference

12 December 2020

Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain

1 reference

12 December 2020

Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system

1 reference

12 December 2020

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1 reference

12 December 2020

Induction of IL-12 gene expression in the brain in septic shock

1 reference

12 December 2020

Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice

1 reference

12 December 2020

Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Devic-like disease in mice

1 reference

12 December 2020

Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS.

1 reference

12 December 2020

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

12 December 2020

T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

1 reference

12 December 2020

Interferon-gamma confers resistance to experimental allergic encephalomyelitis.

1 reference

12 December 2020

Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease?

1 reference

12 December 2020

Transgenic expression of CCL2 in the central nervous system prevents experimental autoimmune encephalomyelitis

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12 December 2020

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice

1 reference

12 December 2020

Involvement of neurofilaments in the radial growth of axons

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12 December 2020

Macrophage/microglial-mediated primary demyelination and motor disease induced by the central nervous system production of interleukin-3 in transgenic mice

1 reference

12 December 2020

The immunogenetics of multiple sclerosis

1 reference

12 December 2020

A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease

1 reference

12 December 2020

Induction of beta-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions.

1 reference

12 December 2020

CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Regulation of interferon-gamma during innate and adaptive immune responses

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12 December 2020

Rat microglial interleukin-3.

1 reference

12 December 2020

Naive CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system.

1 reference

12 December 2020

IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition.

1 reference

12 December 2020

Plasma exchange for severe attacks of CNS demyelination: predictors of response

1 reference

12 December 2020

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1 reference

12 December 2020

IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis

1 reference

12 December 2020

Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins

1 reference

12 December 2020

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

1 reference

12 December 2020

The cytokine signature of MOG-specific CD4 cells in the EAE of C57BL/6 mice.

1 reference

12 December 2020

Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack.

1 reference

12 December 2020

Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes

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12 December 2020

Intragenic sequences affect the expression of the gene encoding glial fibrillary acidic protein

1 reference

12 December 2020

Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

1 reference

12 December 2020

1 reference

12 December 2020

Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expression

1 reference

12 December 2020

Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region

1 reference

12 December 2020

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire

1 reference

12 December 2020

Interaction of multiple nuclear proteins with the promoter region of the mouse 68-kDa neurofilament gene

1 reference

12 December 2020

Neurofilaments are obligate heteropolymers in vivo

1 reference

12 December 2020

GRO-alpha and CXCR2 in the human fetal brain and multiple sclerosis lesions

1 reference

12 December 2020

1 reference

12 December 2020

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

1 reference

12 December 2020

Functional epistasis on a common MHC haplotype associated with multiple sclerosis

1 reference

12 December 2020

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus

1 reference

12 December 2020

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

1 reference

12 December 2020

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1 reference

12 December 2020

Experimental autoimmune encephalomyelitis in IL-4-deficient mice

1 reference

12 December 2020

Multiple sclerosis and optic neuritis: CCR5 and CXCR3 expressing T cells are augmented in blood and cerebrospinal fluid

1 reference

12 December 2020

A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica

1 reference

12 December 2020

Antigen-specific blockade of lethal CD8 T-cell mediated autoimmunity in a mouse model of multiple sclerosis

1 reference

12 December 2020

Tumor necrosis factor alpha and lymphotoxin alpha are not required for induction of acute experimental autoimmune encephalomyelitis.

1 reference

12 December 2020

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1 reference

12 December 2020

From genes to function: the next challenge to understanding multiple sclerosis

1 reference

12 December 2020

Rapid activation of astrocyte-specific expression of GFAP-lacZ transgene by focal injury

1 reference

12 December 2020

Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system

1 reference

12 December 2020

Multiple sclerosis risk after optic neuritis: final optic neuritis treatment trial follow-up

1 reference

12 December 2020

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1 reference

12 December 2020

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

1 reference

12 December 2020

How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis

1 reference

12 December 2020

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha

1 reference

12 December 2020

Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research.

1 reference

12 December 2020

FVB mice transgenic for the H-2Db gene become resistant to persistent infection by Theiler's virus

1 reference

12 December 2020

Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.

1 reference

12 December 2020

Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study

1 reference

12 December 2020

IL-12 production by central nervous system microglia is inhibited by astrocytes

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12 December 2020

A viral peptide with limited homology to a self peptide can induce clinical signs of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions

1 reference

12 December 2020

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

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12 December 2020

IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice

1 reference

12 December 2020

Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis

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12 December 2020

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

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12 December 2020

Astrocytes and microglia produce interleukin-12 p40

1 reference

12 December 2020

Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody

1 reference

12 December 2020

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

1 reference

12 December 2020

Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.

1 reference

12 December 2020

Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis

1 reference

12 December 2020

Evolution of Neuropathologic Abnormalities Associated with Blood-Brain Barrier Breakdown in Transgenic Mice Expressing lnterleukin-6 in Astrocytes

1 reference

12 December 2020

Identification of three forms of human myelin basic protein by cDNA cloning

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12 December 2020

A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis

1 reference

12 December 2020

IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1 reference

12 December 2020

Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice .

1 reference

12 December 2020

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

1 reference

12 December 2020

Extensive infiltration of neutrophils in the acute phase of experimental autoimmune encephalomyelitis in C57BL/6 mice

1 reference

12 December 2020

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

1 reference

12 December 2020

Mechanisms of immune injury in multiple sclerosis

1 reference

12 December 2020

MCP-1, MCP-2 and MCP-3 expression in multiple sclerosis lesions: an immunohistochemical and in situ hybridization study

1 reference

12 December 2020

Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis

1 reference

12 December 2020

Vitamin D and multiple sclerosis

1 reference

12 December 2020

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions

1 reference

12 December 2020

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

1 reference

12 December 2020

The lymphoid chemokine CCL21 costimulates naive T cell expansion and Th1 polarization of non-regulatory CD4+ T cells

1 reference

12 December 2020

Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease

1 reference

12 December 2020

Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis

1 reference

12 December 2020

Induction of experimental autoimmune encephalomyelitis in C57BL/6 mice deficient in either the chemokine macrophage inflammatory protein-1alpha or its CCR5 receptor

1 reference

12 December 2020

Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes

1 reference

12 December 2020

The infection of mouse by Theiler's virus: from genetics to immunology

1 reference

12 December 2020

The M2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane

1 reference

12 December 2020

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1 reference

12 December 2020

A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells

1 reference

12 December 2020

Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease.

1 reference

12 December 2020

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice

1 reference

12 December 2020

Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss

1 reference

12 December 2020

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Immune cells contribute to myelin degeneration and axonopathic changes in mice overexpressing proteolipid protein in oligodendrocytes

1 reference

12 December 2020

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

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12 December 2020

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination.

1 reference

12 December 2020

Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis

1 reference

12 December 2020

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

1 reference

12 December 2020

Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber

1 reference

12 December 2020

Studies on acute disseminated encephalomyelitis produced experimentally in rhesus monkeys

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12 December 2020

The adhesion molecule and cytokine profile of multiple sclerosis lesions

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12 December 2020

Lymphocyte traffic control by chemokines

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12 December 2020

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

1 reference

12 December 2020

Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus-induced demyelinating disease model of multiple sclerosis

1 reference

12 December 2020

High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice

1 reference

12 December 2020

Smoking, use of moist snuff, and risk of chronic inflammatory diseases

1 reference

12 December 2020

Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3

1 reference

12 December 2020

Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis

1 reference

12 December 2020

Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.

1 reference

12 December 2020

Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia

1 reference

12 December 2020

Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes

1 reference

12 December 2020

GFAP promoter directs astrocyte-specific expression in transgenic mice

1 reference

12 December 2020

Association between the ACCN1 gene and multiple sclerosis in Central East Sardinia

1 reference

12 December 2020

Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen

1 reference

12 December 2020

Unique clinical and pathological features in HLA-DRB1*0401-restricted MBP 111-129-specific humanized TCR transgenic mice

1 reference

12 December 2020

Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire

1 reference

12 December 2020

Lymphocytes from SJL/J mice immunized with spinal cord respond selectively to a peptide of proteolipid protein and transfer relapsing demyelinating experimental autoimmune encephalomyelitis

1 reference

12 December 2020

A new window in multiple sclerosis pathology: non-conventional quantitative magnetic resonance imaging outcomes

1 reference

12 December 2020

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

1 reference

12 December 2020

B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice

1 reference

12 December 2020

IL-6 expression in neurons of transgenic mice causes reactive astrocytosis and increase in ramified microglial cells but no neuronal damage.

1 reference

12 December 2020

Patterns of oligodendroglia pathology in multiple sclerosis

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12 December 2020

Chronic complement C3 gene expression in the CNS of transgenic mice with astrocyte-targeted interleukin-6 expression

1 reference

12 December 2020

IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells

1 reference

12 December 2020

Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis.

1 reference

12 December 2020

Molecular mimicry in virus infection: crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments

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12 December 2020

Multiple sclerosis: distribution of inflammatory cells in newly forming lesions

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12 December 2020

Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia.

1 reference

12 December 2020

HLA associations with multiple sclerosis in Sicily and Malta

1 reference

12 December 2020

Transgenic mice for interleukin 3 develop motor neuron degeneration associated with autoimmune reaction against spinal cord motor neurons

1 reference

12 December 2020

Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen

1 reference

12 December 2020

Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage

1 reference

12 December 2020

Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli

1 reference

12 December 2020

Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression

1 reference

12 December 2020

Epitope spreading in immune-mediated diseases: implications for immunotherapy

1 reference

12 December 2020

Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.

1 reference

12 December 2020

Immunology of multiple sclerosis

1 reference

12 December 2020

Engineering chromosomal rearrangements in mice

1 reference

12 December 2020

CD8(+) T cell-mediated spontaneous diabetes in neonatal mice

1 reference

12 December 2020

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

1 reference

12 December 2020

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1 reference

12 December 2020

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors.

1 reference

12 December 2020

Interferon-gamma modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis

1 reference

12 December 2020

Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons

1 reference

12 December 2020

Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene

1 reference

12 December 2020

The enemy within: keeping self-reactive T cells at bay in the periphery

1 reference

12 December 2020

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1 reference

12 December 2020

Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

1 reference

12 December 2020

Specificity requirements for selection and effector functions of CD25+4+ regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice.

1 reference

12 December 2020

B cells regulate autoimmunity by provision of IL-10.

1 reference

12 December 2020

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

1 reference

12 December 2020

Theiler's virus persists in glial cells during demyelinating disease

1 reference

12 December 2020

1 reference

12 December 2020

Experimental models of virus-induced demyelination of the central nervous system

1 reference

12 December 2020

Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

1 reference

12 December 2020

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1 reference

12 December 2020

Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice

1 reference

12 December 2020

Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor-alpha in the central nervous system

1 reference

12 December 2020

Proteolipides, a new type of tissue lipoproteins; their isolation from brain.

1 reference

12 December 2020

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

1 reference

12 December 2020

B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition.

1 reference

12 December 2020

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

1 reference

12 December 2020

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.

1 reference

12 December 2020

Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes

1 reference

12 December 2020

Repertoire dynamics of autoreactive T cells in multiple sclerosis patients and healthy subjects: epitope spreading versus clonal persistence.

1 reference

12 December 2020

Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein

1 reference

12 December 2020

EAE: an immunologist's magic eye.

1 reference

12 December 2020

Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis.

1 reference

12 December 2020

Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage

1 reference

12 December 2020

IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells.

1 reference

12 December 2020

Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice

1 reference

12 December 2020

Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells.

1 reference

12 December 2020

Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients

1 reference

12 December 2020

Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis

1 reference

12 December 2020

GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis

1 reference

12 December 2020

T cell-mediated elimination of B7.2 transgenic B cells

1 reference

12 December 2020

Cortical lesions and brain atrophy in MS.

1 reference

12 December 2020

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

1 reference

12 December 2020

The immunopathology of multiple sclerosis: an overview

1 reference

12 December 2020

The predicted amino acid sequence of alpha-internexin is that of a novel neuronal intermediate filament protein.

1 reference

12 December 2020

Expression of monocyte chemoattractant protein-1 and other beta-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions

1 reference

12 December 2020

10.1007/S00018-010-0481-9

Identifiers

DOI

1 reference

23 August 2017

1 reference