(Q37781692)

23 August 2017

title

Mitochondrial protein import: from proteomics to functional mechanisms (English)

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23 August 2017

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Oliver Schmidt

1

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Chris Meisinger

object named as

Chris Meisinger

series ordinal

3

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author name string

Nikolaus Pfanner

series ordinal

2

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23 August 2017

publication date

1 September 2010

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Nature Reviews Molecular Cell Biology

23 August 2017

published in

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23 August 2017

volume

11

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23 August 2017

issue

9

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23 August 2017

page(s)

655-667

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https://scigraph.springernature.com/pub.10.1038/nrm2959

23 August 2017

exact match

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cites work

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Protein insertion into the mitochondrial inner membrane by a twin-pore translocase

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Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller

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New developments in mitochondrial assembly

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Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins

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Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space

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Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions

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An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane

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The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria.

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Pam16 has an essential role in the mitochondrial protein import motor

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Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain

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The yeast Aac2 protein exists in physical association with the cytochrome bc1-COX supercomplex and the TIM23 machinery

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Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability

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Molecular Chaperone Hsp70/Hsp90 Prepares the Mitochondrial Outer Membrane Translocon Receptor Tom71 for Preprotein Loading

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Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes

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Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

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Role of Tim50 in the transfer of precursor proteins from the outer to the inner membrane of mitochondria

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Tim50 maintains the permeability barrier of the mitochondrial inner membrane

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A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23.

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Interaction of Tim23 with Tim50 Is Essential for Protein Translocation by the Mitochondrial TIM23 Complex

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Role of Tim21 in mitochondrial translocation contact sites

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The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes

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Motor-free mitochondrial presequence translocase drives membrane integration of preproteins

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Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting

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A Role for Tim21 in Membrane-Potential-Dependent Preprotein Sorting in Mitochondria

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The presequence translocase-associated protein import motor of mitochondria. Pam16 functions in an antagonistic manner to Pam18.

31 March 2020

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Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor

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Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor

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Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences

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Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

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Mitochondrial carrier protein biogenesis: role of the chaperones Hsc70 and Hsp90.

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The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria

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The Tim9p-Tim10p complex binds to the transmembrane domains of the ADP/ATP carrier

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The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import

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Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex

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The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases

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Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes

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Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway

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Systematic analysis of the twin cx(9)c protein family.

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Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria

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A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding

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Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space

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MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

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A disulfide relay system in the intermembrane space of mitochondria that mediates protein import

31 March 2020

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The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins

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Erv1 mediates the Mia40-dependent protein import pathway and provides a functional link to the respiratory chain by shuttling electrons to cytochrome c.

31 March 2020

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Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione

31 March 2020

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A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1.

31 March 2020

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The disulfide relay system of mitochondria is connected to the respiratory chain

31 March 2020

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Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase

31 March 2020

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Signals in bacterial beta-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria

31 March 2020

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Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway

31 March 2020

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The Tim8-Tim13 complex of Neurospora crassa functions in the assembly of proteins into both mitochondrial membranes

31 March 2020

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Dissecting membrane insertion of mitochondrial beta-barrel proteins

31 March 2020

1 reference

The peripheral membrane subunits of the SAM complex function codependently in mitochondrial outer membrane biogenesis

31 March 2020

1 reference

The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane

31 March 2020

1 reference

Two modular forms of the mitochondrial sorting and assembly machinery are involved in biogenesis of alpha-helical outer membrane proteins

31 March 2020

1 reference

Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40

31 March 2020

1 reference

Roles of the Mdm10, Tom7, Mdm12, and Mmm1 proteins in the assembly of mitochondrial outer membrane proteins in Neurospora crassa

31 March 2020

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Mim1 functions in an oligomeric form to facilitate the integration of Tom20 into the mitochondrial outer membrane

31 March 2020

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Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors

31 March 2020

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The Transmembrane Segment of Tom20 Is Recognized by Mim1 for Docking to the Mitochondrial TOM Complex

31 March 2020

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Exploration of essential gene functions via titratable promoter alleles

31 March 2020

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Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins

31 March 2020

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A novel insertion pathway of mitochondrial outer membrane proteins with multiple transmembrane segments.

31 March 2020

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Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins

31 March 2020

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Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components

31 March 2020

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Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane

31 March 2020

1 reference

The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria

31 March 2020

1 reference

A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery

31 March 2020

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Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.

31 March 2020

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Mitochondrial inheritance is required for MEN-regulated cytokinesis in budding yeast

31 March 2020

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Mmm2p, a mitochondrial outer membrane protein required for yeast mitochondrial shape and maintenance of mtDNA nucleoids.

31 March 2020

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An ER-mitochondria tethering complex revealed by a synthetic biology screen

31 March 2020

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

31 March 2020

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31 March 2020

Connecting Organelles

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Mouse CLK-1 is imported into mitochondria by an unusual process that requires a leader sequence but no membrane potential

31 March 2020

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Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization.

31 March 2020

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Translation-coupled translocation of yeast fumarase into mitochondria in vivo.

31 March 2020

1 reference

Cytoplasmic type 80S ribosomes associated with yeast mitochondria. IV. Attachment of ribosomes to the outer membrane of isolated mitochondria

31 March 2020

1 reference

Genome-wide analysis of mRNAs targeted to yeast mitochondria

31 March 2020

1 reference

Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner

31 March 2020

1 reference

Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins

31 March 2020

1 reference

Characterization of Mmp37p, a Saccharomyces cerevisiae mitochondrial matrix protein with a role in mitochondrial protein import

31 March 2020

1 reference

Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria

31 March 2020

1 reference

The translocator maintenance protein Tam41 is required for mitochondrial cardiolipin biosynthesis

31 March 2020

1 reference

Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome

31 March 2020

1 reference

The TOM core complex: the general protein import pore of the outer membrane of mitochondria.

31 March 2020

1 reference

Cryo-electron microscopy structure of a yeast mitochondrial preprotein translocase

31 March 2020

1 reference

Mitochondrial protein-import machinery: correlating structure with function

31 March 2020

1 reference

The pathophysiology of mitochondrial disease as modeled in the mouse

31 March 2020

1 reference

Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase

31 March 2020

1 reference

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

31 March 2020

1 reference

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

31 March 2020

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Proteome analysis of mitochondrial outer membrane from Neurospora crassa

31 March 2020

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Profiling constitutive proteolytic events in vivo

31 March 2020

1 reference

Systematic identification of mitochondrial proteins by LC-MS/MS.

31 March 2020

1 reference

Characterization of the human heart mitochondrial proteome

31 March 2020

1 reference

Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins

31 March 2020

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Integrative analysis of the mitochondrial proteome in yeast

31 March 2020

1 reference

Quantitative Proteomic Comparison of Rat Mitochondria from Muscle, Heart, and Liver

31 March 2020

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Exploring the mitochondrial proteome of the ciliate protozoon Tetrahymena thermophila: direct analysis by tandem mass spectrometry.

31 March 2020

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Expanded protein information at SGD: new pages and proteome browser.

31 March 2020

1 reference

The m-AAA protease defective in hereditary spastic paraplegia controls ribosome assembly in mitochondria

31 March 2020

1 reference

Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase.

31 March 2020

1 reference

The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase

31 March 2020

1 reference

The mitochondrial IMP peptidase of yeast: functional analysis of domains and identification of Gut2 as a new natural substrate

31 March 2020

1 reference

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria

31 March 2020

1 reference

12 December 2020

Proteomic approach to identify novel mitochondrial proteins in Arabidopsis.

1 reference

12 December 2020

Phospholipid synthesis in a membrane fraction associated with mitochondria

1 reference

12 December 2020

The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM2959

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Dimensions Publication ID

23 August 2017

1013141887

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