(Q37790693)

23 August 2017

G protein coupled receptors as allosteric proteins and the role of allosteric modulators (English)

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G protein-coupled receptor

23 August 2017

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author name string

Terry Kenakin

series ordinal

1

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23 August 2017

1 October 2010

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Journal of Receptors and Signal Transduction

23 August 2017

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23 August 2017

30

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23 August 2017

5

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23 August 2017

313-321

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The feedback control mechanisms of biosynthetic L-threonine deaminase by L-isoleucine

23 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Teleonomic mechanisms in cellular metabolism, growth, and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Allostery: an illustrated definition for the 'second secret of life'.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

GPCR drug discovery through the exploitation of allosteric drug binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

The Energy Landscapes and Motions of Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

A statistical thermodynamic model of the protein ensemble

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Evolutionarily conserved pathways of energetic connectivity in protein families

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Intrinsic disorder in transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Multiple charged and aromatic residues in CCR5 amino-terminal domain are involved in high affinity binding of both chemokines and HIV-1 Env protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Naturally occurring CCR5 extracellular and transmembrane domain variants affect HIV-1 Co-receptor and ligand binding function

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

A linear correlation between the energetics of allosteric communication and protein flexibility in the Escherichia coli cyclic AMP receptor protein revealed by mutation-induced changes in compressibility and amide hydrogen-deuterium exchange.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

New concepts in drug discovery: collateral efficacy and permissive antagonism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

A novel mechanism of activity-dependent NMDA receptor antagonism describes the effect of ifenprodil in rat cultured cortical neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Allosteric modulation of the cannabinoid CB1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Opposite effects of alcuronium on agonist and on antagonist binding to muscarinic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Identification of a major co-receptor for primary isolates of HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

gp120: Biologic aspects of structural features

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Collateral efficacy as a pharmacological problem applied to new drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

HIV co-receptor inhibitors as novel class of anti-HIV drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Spontaneous and antigen-induced production of HIV-inhibitory beta-chemokines are associated with AIDS-free status

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Induction of G1 cycle arrest in T lymphocytes results in increased extracellular levels of beta-chemokines: a strategy to inhibit R5 HIV-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Anti-Human Immunodeficiency Virus Activity of Tau Interferon in Human Macrophages: Involvement of Cellular Factors and β-Chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Production of beta-chemokines in human immunodeficiency virus (HIV) infection: evidence that high levels of macrophage inflammatory protein-1beta are associated with a decreased risk of HIV disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Inhibition of HIV-1 replication by GB virus C infection through increases in RANTES, MIP-1alpha, MIP-1beta, and SDF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Detection of elevated serum beta-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Cell surface expression of CCR5 and other host factors influence the inhibition of HIV-1 infection of human lymphocytes by CCR5 ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

The relative activity of "function sparing" HIV-1 entry inhibitors on viral entry and CCR5 internalization: is allosteric functional selectivity a valuable therapeutic property?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Beta-arrestin-biased ligands at seven-transmembrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Drug efficacy at G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Multiple signaling states of G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Regulation of receptor-coupling to (multiple) G proteins. A challenge for basic research and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Physiological and pharmacological implications of beta-arrestin regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Molecular determinants of angiotensin II type 1 receptor functional selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Beta-blockers in heart failure: are pharmacological differences clinically important?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Serotonergic antagonist effects on trafficking of serotonin 5-HT2A receptors in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10799893.2010.503964

10.3109/10799893.2010.503964

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

20858023