(Q37795596)

23 August 2017

9 references

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

3 November 2020

Targeting Toll-like receptors for treatment of SLE (English)

1 reference

systemic lupus erythematosus

23 August 2017

2 references

4 August 2019

3 November 2020

9 references

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

3 November 2020

cell surface receptor

1 reference

pattern recognition receptors

31 July 2019

1 reference

3 August 2019

1 reference

15 December 2019

Christopher G Horton

1

1 reference

PMCID

2945668

23 August 2017

Zi-jian Pan

series ordinal

2

1 reference

PMCID

2945668

23 August 2017

A Darise Farris

series ordinal

3

1 reference

23 August 2017

19 September 2010

10 references

Mediators of Inflammation

23 August 2017

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

3 November 2020

10 references

23 August 2017

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

3 November 2020

2010

1 reference

Creative Commons Attribution 3.0 Unported

23 August 2017

9 references

12 March 2019

13 March 2019

17 June 2019

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

on focus list of Wikimedia project

3 November 2020

copyright status

copyrighted

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ScienceSource

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cites work

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Increased toll-like receptor (TLR) 2 and TLR4 expression in monocytes from patients with type 1 diabetes: further evidence of a proinflammatory state

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

6 September 2017

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

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Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors

6 September 2017

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TLR pathways and IFN-regulatory factors: to each its own.

6 September 2017

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Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

6 September 2017

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Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.

6 September 2017

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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

6 September 2017

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A comprehensive map of the toll-like receptor signaling network

6 September 2017

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Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

6 September 2017

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Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

6 September 2017

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Pathogen recognition and innate immunity

6 September 2017

1 reference

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Negative regulation of Toll-like-receptor signaling by IRF-4.

6 September 2017

1 reference

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

6 September 2017

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6 September 2017

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Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

6 September 2017

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Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation

6 September 2017

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

6 September 2017

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Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

6 September 2017

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6 September 2017

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Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

6 September 2017

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

6 September 2017

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Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

6 September 2017

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

6 September 2017

1 reference

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

6 September 2017

1 reference

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A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

IRAK-M is a negative regulator of Toll-like receptor signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Genetic modifiers of systemic lupus erythematosus in FcgammaRIIB(-/-) mice

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

NF-kappaB signaling pathways in mammalian and insect innate immunity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Toll-like receptors: critical proteins linking innate and acquired immunity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

IRF family of transcription factors as regulators of host defense

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Circulating DNA in systemic lupus erythematosus. Isolation and characterization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Loss of the innate immunity negative regulator IRAK-M leads to enhanced host immune defense against tumor growth

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Toll-like receptors and innate immune responses in systemic lupus erythematosus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Genetic variation in toll-like receptor 9 and susceptibility to systemic lupus erythematosus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Toll-like receptor 9 signaling protects against murine lupus

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2945668

Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice

1 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2010%2F498980

Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus. Correlation with serum antinucleosome antibody titers and absence of clear association with disease activity

21 January 2018

2 references

Crossref

https://api.crossref.org/works/10.1155%2F2010%2F498980

21 January 2018

12 December 2020

Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus

1 reference

12 December 2020

Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus

1 reference

12 December 2020

Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells

1 reference

12 December 2020

Toll-like receptor signaling pathways

1 reference

12 December 2020

Serum interferon levels in patients with systemic lupus erythematosus

1 reference

12 December 2020

CD40 ligand expressed on B cells in the BXSB mouse model of systemic lupus erythematosus

1 reference

12 December 2020

Peptide-mediated interference of TIR domain dimerization in MyD88 inhibits interleukin-1-dependent activation of NF-{kappa}B

1 reference

12 December 2020

Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells

1 reference

12 December 2020

Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese

1 reference

12 December 2020

Dysregulated Toll-like receptor expression and signaling in bone marrow-derived macrophages at the onset of diabetes in the non-obese diabetic mouse

1 reference

12 December 2020

Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus

1 reference

12 December 2020

Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE

1 reference

12 December 2020

Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process

1 reference

12 December 2020

Toll-like receptor expression in lupus peripheral blood mononuclear cells

1 reference

12 December 2020

1 reference

12 December 2020

Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production

1 reference

12 December 2020

Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus

1 reference

12 December 2020

Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetes

1 reference

12 December 2020

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

1 reference

12 December 2020

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

1 reference

12 December 2020

Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus

1 reference

12 December 2020

Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis

1 reference

12 December 2020

Dynamics of the RING domain from human TRAF6 by 15N NMR spectroscopy: implications for biological function

1 reference

12 December 2020

Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)

1 reference

12 December 2020

Regression of systemic lupus erythematosus after development of an acquired toll-like receptor signaling defect and antibody deficiency

1 reference

12 December 2020

Identifiers

DOI

10.1155/2010/498980

1 reference

23 August 2017

1 reference

23 August 2017

1 reference

PMCID

2945668