(Q37803540)

23 August 2017

7 references

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

26 August 2020

3 November 2020

Toll-like receptor signaling pathways--therapeutic opportunities (English)

1 reference

23 August 2017

2 references

4 August 2019

3 November 2020

7 references

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

26 August 2020

3 November 2020

cell surface receptor

1 reference

pattern recognition receptors

31 July 2019

1 reference

3 August 2019

1 reference

15 December 2019

1 reference

26 August 2020

Jiankun Zhu

1

1 reference

PMCID

2963142

23 August 2017

Chandra Mohan

series ordinal

2

1 reference

23 August 2017

17 October 2010

8 references

Mediators of Inflammation

23 August 2017

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

26 August 2020

3 November 2020

8 references

23 August 2017

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

26 August 2020

3 November 2020

2010

1 reference

23 August 2017

781235

1 reference

Creative Commons Attribution 3.0 Unported

23 August 2017

7 references

30 June 2019

31 July 2019

3 August 2019

4 August 2019

15 December 2019

26 August 2020

on focus list of Wikimedia project

3 November 2020

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice

1 reference

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A cell biological view of Toll-like receptor function: regulation through compartmentalization.

6 September 2017

1 reference

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Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

6 September 2017

1 reference

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Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production.

6 September 2017

1 reference

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Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

6 September 2017

1 reference

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The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

6 September 2017

1 reference

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Toll-like receptors in autoimmunity

6 September 2017

1 reference

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Acetylation of MKP-1 and the control of inflammation.

6 September 2017

1 reference

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Pyogenic bacterial infections in humans with MyD88 deficiency

6 September 2017

1 reference

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Toll-like receptor 9 (TLR9) agonists in the treatment of cancer

6 September 2017

1 reference

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Role of TLRs/MyD88 in host resistance and pathogenesis during protozoan infection: lessons from malaria.

6 September 2017

1 reference

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Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88

6 September 2017

1 reference

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Increased toll-like receptor 9 expression in cervical neoplasia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Oligodeoxynucleotide CpG 7909 delivered as intravenous infusion demonstrates immunologic modulation in patients with previously treated non-Hodgkin lymphoma

6 September 2017

1 reference

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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

MyD88 is pivotal for the early inflammatory response and subsequent bacterial clearance and survival in a mouse model of Chlamydia pneumoniae pneumonia

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Human lung cancer cells express functionally active Toll-like receptor 9

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Influence of coinfecting pathogens on HIV expression: evidence for a role of Toll-like receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3...

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Selective up-regulation of CDK2 is critical for TLR9 signaling stimulated proliferation of human lung cancer cell

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

TLR9 signaling promotes tumor progression of human lung cancer cell in vivo

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Toll-like receptors on tumor cells facilitate evasion of immune surveillance

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

The human Burkitt lymphoma cell line Namalwa represents a homogenous cell system characterized by high levels of Toll-like receptor 9 and activation by CpG oligonucleotides

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Toll-like receptor-9 expression is inversely correlated with estrogen receptor status in breast cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Toll-like receptor 2 variants are associated with acute reactive arthritis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2963142

Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound

1 October 2018

1 reference

12 December 2020

Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection

1 reference

12 December 2020

Immune-mediated tumor regression induced by CpG-containing oligodeoxynucleotides

1 reference

12 December 2020

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

1 reference

12 December 2020

The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis

1 reference

12 December 2020

Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk

1 reference

12 December 2020

Regression of systemic lupus erythematosus after development of an acquired toll-like receptor signaling defect and antibody deficiency

1 reference

12 December 2020

Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus

1 reference

12 December 2020

Expression of toll-like receptor-9 is increased in poorly differentiated prostate tumors

1 reference

12 December 2020

Phase II trial of a toll-like receptor 9-activating oligonucleotide in patients with metastatic melanoma

1 reference

12 December 2020

Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice

1 reference

12 December 2020

Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus

1 reference

12 December 2020

Identifiers

DOI

10.1155/2010/781235

1 reference

23 August 2017

1 reference

23 August 2017

1 reference

PMCID

2963142