(Q37807924)

23 August 2017

title

Platelet receptor signaling in thrombus formation (English)

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23 August 2017

1

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author name string

Bernhard Nieswandt

series ordinal

2

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23 August 2017

publication date

7 November 2010

1 reference

Journal of Molecular Medicine

23 August 2017

published in

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23 August 2017

volume

89

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23 August 2017

issue

2

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23 August 2017

page(s)

109-121

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Platelets in atherothrombosis

23 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

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21 January 2018

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21 January 2018

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GPVI and CLEC-2 in hemostasis and vascular integrity

21 January 2018

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Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations

21 January 2018

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A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder

21 January 2018

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A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion

21 January 2018

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Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface.

21 January 2018

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Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice

21 January 2018

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Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation

21 January 2018

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Integrin α2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen

21 January 2018

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Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy

21 January 2018

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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

21 January 2018

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Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.

21 January 2018

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Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

21 January 2018

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Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

21 January 2018

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Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets

21 January 2018

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You say ITAM and I say ITIM, let's call the whole thing off: the ambiguity of immunoreceptor signalling

21 January 2018

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Platelet endothelial cell adhesion molecule-1 serves as an inhibitory receptor that modulates platelet responses to collagen

21 January 2018

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CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo

21 January 2018

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The novel inhibitory receptor G6B is expressed on the surface of platelets and attenuates platelet function in vitro

21 January 2018

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A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

12 December 2020

Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice

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Lineage-specific overexpression of the P2Y1 receptor induces platelet hyper-reactivity in transgenic mice.

21 January 2018

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21 January 2018

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Identification of the platelet ADP receptor targeted by antithrombotic drugs

21 January 2018

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Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding

21 January 2018

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A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo

21 January 2018

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P2X(1)-mediated activation of extracellular signal-regulated kinase 2 contributes to platelet secretion and aggregation induced by collagen

21 January 2018

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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

21 January 2018

1 reference

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Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Role of tissue factor in hemostasis, thrombosis, and vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Disulfide isomerization switches tissue factor from coagulation to cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Tissue factor activation: is disulfide bond switching a regulatory mechanism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Defective thrombus formation in mice lacking coagulation factor XII

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Rivaroxaban: a new oral factor Xa inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Apixaban: an emerging oral factor Xa inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

G-protein-coupled receptors as signaling targets for antiplatelet therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Thrombin signalling and protease-activated receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Role of thrombin signalling in platelets in haemostasis and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Blocking the protease-activated receptor 1-4 heterodimer in platelet-mediated thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Reduced thrombus stability in mice lacking the alpha2A-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Type I phosphoinositide 3-kinases: potential antithrombotic targets?

21 January 2018

1 reference

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Taming platelets with cyclic nucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Minding the gaps to promote thrombus growth and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Calcium signaling in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

STIM1, an essential and conserved component of store-operated Ca2+ channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

R93W mutation in Orai1 causes impaired calcium influx in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Diverse functions of protein kinase C isoforms in platelet activation and thrombus formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Rap1b is required for normal platelet function and hemostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

21 January 2018

Glanzmann thrombasthenia

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Glycoprotein IIb/IIIa inhibitors in clinical practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Soluble CD40 ligand induces β 3 integrin tyrosine phosphorylation and triggers platelet activation by outside-in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Role for ADAP in shear flow-induced platelet mechanotransduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Kindlin-3 is essential for integrin activation and platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Targeting of the collagen-binding site on glycoprotein VI is not essential for in vivo depletion of the receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-010-0691-5

Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha

21 January 2018

1 reference

12 December 2020

Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis

1 reference

12 December 2020

CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis

1 reference

12 December 2020

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

1 reference

12 December 2020

Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen

1 reference

12 December 2020

A critical role for extracellular protein disulfide isomerase during thrombus formation in mice

1 reference

12 December 2020

Reduced incidence of ischemic stroke in patients with severe factor XI deficiency

1 reference

12 December 2020

Contribution of distinct adhesive interactions to platelet aggregation in flowing blood

1 reference

12 December 2020

Anti-inflammatory drugs and their mechanism of action

1 reference

12 December 2020

Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets

1 reference

12 December 2020

PAR3 is a cofactor for PAR4 activation by thrombin

1 reference

12 December 2020

Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human blood

1 reference

12 December 2020

Thrombasthenic mice generated by replacement of the integrin alpha(IIb) gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment.

1 reference

12 December 2020

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

1 reference

12 December 2020

Platelets activated by collagen through immunoreceptor tyrosine-based activation motif play pivotal role in initiation and generation of neointimal hyperplasia after vascular injury

1 reference

12 December 2020

PKCalpha regulates platelet granule secretion and thrombus formation in mice

1 reference

12 December 2020

CD40L stabilizes arterial thrombi by a β3 integrin–dependent mechanism

1 reference

12 December 2020

Stable adhesion and migration of human neutrophils requires phospholipase D-mediated activation of the integrin CD11b/CD18

1 reference

12 December 2020

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice

1 reference

12 December 2020

Phospholipase A2: its role in ADP- and thrombin-induced platelet activation mechanisms

1 reference

12 December 2020

The P2Y1 receptor is necessary for adenosine 5'-diphosphate-induced platelet aggregation.

1 reference

12 December 2020

Platelet P2Y12 receptor inhibition by thienopyridines: status and future

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12 December 2020

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

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12 December 2020

A dual thrombin receptor system for platelet activation

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12 December 2020

Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura.

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12 December 2020

Defective platelet activation in G alpha(q)-deficient mice.

1 reference

12 December 2020

10.1007/S00109-010-0691-5

Identifiers

DOI

1 reference

23 August 2017

1 reference