(Q37809337)

English

Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia

scientific article published on 15 October 2010

In more languages

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

Anemia, ineffective erythropoiesis, and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in β-thalassemia (English)

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

0 references

1 reference

based on heuristic

inferred from title

ineffective erythropoiesis

1 reference

based on heuristic

inferred from title

Stefano Rivella

3

0 references

author name string

Sara Gardenghi

1

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

Robert W Grady

2

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

publication date

15 October 2010

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

Hematology / Oncology Clinics of North America

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

24

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

1089-1107

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

Gene therapy in thalassemia and hemoglobinopathies.

1 reference

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Metabolism and the leukemic stem cell.

1 reference

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Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia

1 reference

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Expression of growth differentiation factor 15 is not elevated in individuals with iron deficiency secondary to volunteer blood donation

1 reference

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Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

1 reference

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6 September 2017

Future alternative therapies for β-thalassemia

1 reference

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Mechanisms of mutations in myeloproliferative neoplasms

1 reference

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6 September 2017

The role of hepcidin in iron metabolism

1 reference

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Vascular complications after splenectomy for hematologic disorders

1 reference

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Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

1 reference

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6 September 2017

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

1 reference

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6 September 2017

Ineffective erythropoiesis and thalassemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

1 reference

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The JAK2V617F mutation in polycythemia vera and other myeloproliferative disorders: one mutation for three diseases?

1 reference

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6 September 2017

Regulation of iron absorption in hemoglobinopathies.

1 reference

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6 September 2017

The role of oxidative stress in hemolytic anemia

1 reference

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6 September 2017

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Forging a field: the golden age of iron biology

1 reference

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6 September 2017

Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

1 reference

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6 September 2017

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

The serine protease TMPRSS6 is required to sense iron deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

1 reference

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6 September 2017

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

1 reference

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6 September 2017

Negative autoregulation by FAS mediates robust fetal erythropoiesis

1 reference

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6 September 2017

Foxo3 is required for the regulation of oxidative stress in erythropoiesis

1 reference

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6 September 2017

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

1 reference

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EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts

1 reference

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6 September 2017

Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

1 reference

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6 September 2017

Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

1 reference

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6 September 2017

Suppression of hepcidin during anemia requires erythropoietic activity

1 reference

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Interleukin-6 induces hepcidin expression through STAT3

1 reference

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6 September 2017

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

1 reference

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6 September 2017

Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

1 reference

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A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

1 reference

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Urinary hepcidin in congenital chronic anemias

1 reference

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1 reference

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Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

1 reference

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6 September 2017

Hepcidin in iron overload disorders

1 reference

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6 September 2017

In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia.

1 reference

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Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization

1 reference

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6 September 2017

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

1 reference

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6 September 2017

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

1 reference

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Chelation therapy in beta-thalassemia: an optimistic update

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Clinical management of beta-thalassemia major

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6 September 2017

A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

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6 September 2017

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

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6 September 2017

Single gene disorders or complex traits: lessons from the thalassaemias and other monogenic diseases

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LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity

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Disorders of iron metabolism

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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

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Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family

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6 September 2017

A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis

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6 September 2017

A mouse model for beta 0-thalassemia

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6 September 2017

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

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6 September 2017

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1 reference

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6 September 2017

Expression cloning of the murine erythropoietin receptor

1 reference

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6 September 2017

Oxidative denaturation of red blood cells in thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

6 September 2017

Erythropoietin receptor: cloning strategy and structural features

1 reference

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6 September 2017

Liver iron concentrations and urinary hepcidin in beta-thalassemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

14 September 2017

Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera.

1 reference

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14 September 2017

Ferrokinetics in man

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14 September 2017

The management of patients with Cooley's anemia: transfusions and splenectomy

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28 September 2017

Oxidative stress in red blood cells, platelets and polymorphonuclear leukocytes from patients with myelodysplastic syndrome

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23 June 2018

Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR.

1 reference

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23 June 2018

The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

23 June 2018

The morbidity of bone disease in thalassemia

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23 June 2018

Transferrin therapy ameliorates disease in beta-thalassemic mice.

1 reference

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1 September 2018

Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts

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1 September 2018

Stroke in thalassemia: a dilemma.

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1 September 2018

Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

1 September 2018

Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

1 September 2018

The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2991049

1 September 2018

Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis

1 reference

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1 September 2018

Core erythropoietin receptor signals for late erythroblast development

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1 September 2018

Roles for an Epo receptor Tyr-343 Stat5 pathway in proliferative co-signaling with kit.

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1 September 2018

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1 September 2018

Ineffective erythropoiesis in beta-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage.

1 reference

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1 September 2018

The importance of erythroid expansion in determining the extent of apoptosis in erythroid precursors in patients with beta-thalassemia major.

1 reference

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1 September 2018

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

1 reference

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1 October 2018

Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation

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3 December 2018

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3 December 2018

Accelerated programmed cell death (apoptosis) in erythroid precursors of patients with severe beta-thalassemia (Cooley's anemia)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compensatory increase in levels of beta minor globin in murine beta-thalassemia is under translational control

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Iron metabolism in thalassemia intermedia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JAK2 Mutations are present in all cases of polycythemia vera

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mouse model for β-thalassemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of homozygous beta-thalassemia by carrier screening and antenatal diagnosis in Sardinians

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mRNA expression of iron regulatory genes in β-thalassemia intermedia and β-thalassemia major mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glucocorticoid receptor cooperates with the erythropoietin receptor and c-Kit to enhance and sustain proliferation of erythroid progenitors in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepcidin, a new iron regulatory peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased hepcidin mRNA expression in thalassemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/21075282

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.HOC.2010.08.003

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 August 2017

ResearchGate publication ID

0 references

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