(Q37815127)

23 August 2017

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title

Cancer stem cells: problems for therapy? (English)

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23 August 2017

main subject

neoplastic stem cells

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Malcolm R Alison

1

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23 August 2017

Susan M L Lim

series ordinal

2

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23 August 2017

Linda J Nicholson

series ordinal

3

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23 August 2017

publication date

25 October 2010

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23 August 2017

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23 August 2017

volume

223

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23 August 2017

issue

2

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23 August 2017

page(s)

147-161

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23 August 2017

cites work

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21 January 2018

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A perivascular niche for brain tumor stem cells

21 January 2018

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Attributes of adult stem cells

21 January 2018

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Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells

21 January 2018

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Crypt stem cells as the cells-of-origin of intestinal cancer

21 January 2018

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Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

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Cancer stem cells: models and concepts

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Leukemia stem cells in acute myeloid leukemia.

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

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Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

21 January 2018

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Sarcoma derived from cultured mesenchymal stem cells

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Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2.

21 January 2018

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EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells

21 January 2018

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Identification of cancer stem cells in Ewing's sarcoma

21 January 2018

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Stem cells in cancer: instigators and propagators?

21 January 2018

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Identification of cells initiating human melanomas

21 January 2018

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Efficient tumour formation by single human melanoma cells

21 January 2018

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Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice

21 January 2018

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Identification of tumor-initiating cells in a p53-null mouse model of breast cancer

21 January 2018

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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma

21 January 2018

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The epithelial-mesenchymal transition generates cells with properties of stem cells

21 January 2018

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Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells

21 January 2018

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Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

21 January 2018

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Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition

21 January 2018

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

21 January 2018

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Gastrointestinal stem cells in development and cancer

21 January 2018

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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

21 January 2018

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Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer

21 January 2018

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Out of Eden: stem cells and their niches

21 January 2018

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Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431.

21 January 2018

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Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma.

21 January 2018

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

21 January 2018

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Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells

21 January 2018

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The leukemic stem cell niche: current concepts and therapeutic opportunities

21 January 2018

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The clonal evolution of tumor cell populations

21 January 2018

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Cancer stem cells: back to Darwin?

21 January 2018

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Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

21 January 2018

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Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

21 January 2018

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Molecular definition of breast tumor heterogeneity

21 January 2018

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A stochastic model for cancer stem cell origin in metastatic colon cancer

21 January 2018

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21 January 2018

Brain cancer stem cells.

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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature

21 January 2018

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

21 January 2018

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The CD44+/CD24- phenotype is enriched in basal-like breast tumors

21 January 2018

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

21 January 2018

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The CXCR4/CXCL12 axis in endometrial cancer.

21 January 2018

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CXCR4 receptor positive spheroid forming cells are responsible for tumor invasion in vitro

21 January 2018

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Cancer stem cell-like SP cells have a high adhesion ability to the peritoneum in gastric carcinoma

21 January 2018

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Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

21 January 2018

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Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer.

21 January 2018

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Biological and molecular heterogeneity of breast cancers correlates with their cancer stem cell content

21 January 2018

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How powerful is CD133 as a cancer stem cell marker in brain tumors?

21 January 2018

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Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients.

21 January 2018

1 reference

Neurosphere formation is an independent predictor of clinical outcome in malignant glioma

21 January 2018

1 reference

The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer

21 January 2018

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CD133 expression is correlated with lymph node metastasis and vascular endothelial growth factor-C expression in pancreatic cancer

21 January 2018

1 reference

Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression

21 January 2018

1 reference

Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers.

21 January 2018

1 reference

Aldehyde dehydrogenase 1-positive cancer stem cells mediate metastasis and poor clinical outcome in inflammatory breast cancer

21 January 2018

1 reference

ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome

21 January 2018

1 reference

Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma

21 January 2018

1 reference

Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer.

21 January 2018

1 reference

Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer

21 January 2018

1 reference

Expression of ABCC-type nucleotide exporters in blasts of adult acute myeloid leukemia: relation to long-term survival

21 January 2018

1 reference

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

21 January 2018

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Exploring the role of cancer stem cells in radioresistance

21 January 2018

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Cancer stem cells at the crossroads of current cancer therapy failures--radiation oncology perspective

21 January 2018

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

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Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

21 January 2018

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Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy

21 January 2018

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CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway.

21 January 2018

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Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties

21 January 2018

1 reference

HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

21 January 2018

1 reference

Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation

21 January 2018

1 reference

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

1 reference

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

21 January 2018

1 reference

The emerging role of EpCAM in cancer and stem cell signaling

21 January 2018

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

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Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

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Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

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Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells

21 January 2018

1 reference

Targeting Notch to target cancer stem cells.

21 January 2018

1 reference

Aberrant activation of notch signaling in human breast cancer

21 January 2018

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Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

21 January 2018

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Therapeutic antibody targeting of individual Notch receptors

21 January 2018

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Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

21 January 2018

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Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells

21 January 2018

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Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate

21 January 2018

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Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells.

21 January 2018

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

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Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival

21 January 2018

1 reference

Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression

21 January 2018

1 reference

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

1 reference

Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models

21 January 2018

1 reference

A MicroRNA targeting dicer for metastasis control

21 January 2018

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MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma

21 January 2018

1 reference

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

21 January 2018

1 reference

MicroRNAs and glioblastoma; the stem cell connection

21 January 2018

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microRNA-34a is tumor suppressive in brain tumors and glioma stem cells

21 January 2018

1 reference

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

21 January 2018

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Targeting breast stem cells with the cancer preventive compounds curcumin and piperine

21 January 2018

1 reference

Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells

21 January 2018

1 reference

Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling

21 January 2018

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Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics

21 January 2018

1 reference

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

21 January 2018

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Retinoid signaling regulates breast cancer stem cell differentiation

21 January 2018

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CD90 and CD110 correlate with cancer stem cell potentials in human T-acute lymphoblastic leukemia cells

21 January 2018

1 reference

Hoechst 33342 side population identification is a conserved and unified mechanism in urological cancers

21 January 2018

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Identification and expansion of human colon-cancer-initiating cells

21 January 2018

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Phenotypic characterization of human colorectal cancer stem cells

21 January 2018

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Characterization of a subpopulation of colon cancer cells with stem cell-like properties

21 January 2018

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Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis

21 January 2018

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Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer

21 January 2018

1 reference

Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors

21 January 2018

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Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells.

21 January 2018

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Identification of gastric cancer stem cells using the cell surface marker CD44.

21 January 2018

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Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma

21 January 2018

1 reference

Squamous cell cancers contain a side population of stem-like cells that are made chemosensitive by ABC transporter blockade

21 January 2018

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Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes

21 January 2018

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Single-marker identification of head and neck squamous cell carcinoma cancer stem cells with aldehyde dehydrogenase.

21 January 2018

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Significance of CD90+ cancer stem cells in human liver cancer

21 January 2018

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Identification and characterization of tumorigenic liver cancer stem/progenitor cells

21 January 2018

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Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations.

21 January 2018

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Circulating clonotypic B cells in classic Hodgkin lymphoma

21 January 2018

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Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-positive cells

21 January 2018

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Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction

21 January 2018

1 reference

Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer.

21 January 2018

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Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271

21 January 2018

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A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

21 January 2018

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Detection and characterization of CD133+ cancer stem cells in human solid tumours

21 January 2018

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Identification and characterization of ovarian cancer-initiating cells from primary human tumors

21 January 2018

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Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance

21 January 2018

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Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells

21 January 2018

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Identification of pancreatic cancer stem cells

21 January 2018

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Prospective identification of tumorigenic prostate cancer stem cells

21 January 2018

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Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature

21 January 2018

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CD44+ CD24(-) prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis

21 January 2018

1 reference

Tumor initiating cells: development and critical characterization of a model derived from the A431 carcinoma cell line forming spheres in suspension.

21 January 2018

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The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

1 reference

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

21 January 2018

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Clonal origin of columnar, mucous, and endocrine cell lineages in human colorectal epithelium

21 January 2018

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Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

21 January 2018

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One renegade cancer stem cell?

21 January 2018

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CD44 is of Functional Importance for Colorectal Cancer Stem Cells

21 January 2018

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Mammosphere-forming cells from breast cancer cell lines as a tool for the identification of CSC-like- and early progenitor-targeting drugs

21 January 2018

1 reference

Identification of a tumor-initiating stem cell population in human renal carcinomas

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/PATH.2793

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23 August 2017

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