(Q37823829)

23 August 2017

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title

Seeing the forest for the trees: fluorescence studies of single enzymes in the context of ensemble experiments (English)

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23 August 2017

Yan-Wen Tan

1

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23 August 2017

Haw Yang

series ordinal

2

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23 August 2017

language of work or name

English

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publication date

23 December 2010

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Physical Chemistry Chemical Physics

23 August 2017

published in

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23 August 2017

volume

13

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23 August 2017

issue

5

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23 August 2017

page(s)

1709-1721

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Illuminating the mechanistic roles of enzyme conformational dynamics

23 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Adenylate kinase motions during catalysis: an energetic counterweight balancing substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Conformation coupled enzyme catalysis: single-molecule and transient kinetics investigation of dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Information bounds and optimal analysis of dynamic single molecule measurements

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Illuminating single molecules in condensed matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Quantitative single-molecule conformational distributions: a case study with poly-(L-proline).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The design plan of kinesin motors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

A processive single-headed motor: kinesin superfamily protein KIF1A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The cell as a collection of protein machines: preparing the next generation of molecular biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The Energy Landscapes and Motions of Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Quantitative measurements of force and displacement using an optical trap

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Biological applications of optical forces

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Single myosin molecule mechanics: piconewton forces and nanometre steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Kinesin hydrolyses one ATP per 8-nm step

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Direct observation of kinesin stepping by optical trapping interferometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Zwischenmolekulare Energiewanderung und Fluoreszenz

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

A Theory of Sensitized Luminescence in Solids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Do-it-yourself guide: how to use the modern single-molecule toolkit

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

A practical guide to single-molecule FRET

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Single-molecule fluorescence studies of protein folding and conformational dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Fluorescence spectroscopy of single biomolecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Protein folding studied by single-molecule FRET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Protein folding in the cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

RNA folding dynamics by single-molecule fluorescence resonance energy transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The way things move: looking under the hood of molecular motor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The molecular motor toolbox for intracellular transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

How enzymes work: analysis by modern rate theory and computer simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Mechanism of adenylate kinase: site-directed mutagenesis versus X-ray and NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Flavoenzymes: diverse catalysts with recurrent features

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Single-molecule enzymatic dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Oxygen access to the active site of cholesterol oxidase through a narrow channel is gated by an Arg-Glu pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Crystal structure of cholesterol oxidase from Brevibacterium sterolicum refined at 1.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

When does the Michaelis-Menten equation hold for fluctuating enzymes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Functional conformational motions in the turnover cycle of cholesterol oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Conformational-relaxation models of single-enzyme kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

An interpretation of fluctuations in enzyme catalysis rate, spectral diffusion, and radiative component of lifetimes in terms of electric field fluctuations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Protein conformational dynamics probed by single-molecule electron transfer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Protein dynamics and electrostatics in the function of p-hydroxybenzoate hydroxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The PHBH fold: Not only flavoenzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Crystal structure of p-hydroxybenzoate hydroxylase complexed with its reaction product 3,4-dihydroxybenzoate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The mobile flavin of 4-OH benzoate hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Conformational dynamics of the isoalloxazine in substrate-free p-hydroxybenzoate hydroxylase: single-molecule studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Real-time enzyme dynamics illustrated with fluorescence spectroscopy of p-hydroxybenzoate hydroxylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Biological and chemical applications of fluorescence correlation spectroscopy: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Generic schemes for single-molecule kinetics. 1: Self-consistent pathway solutions for renewal processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The methotrexate story: a paradigm for development of cancer chemotherapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

An NMR perspective on enzyme dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Dynamics of a flexible loop in dihydrofolate reductase from Escherichia coli and its implication for catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The dynamic energy landscape of dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Millisecond timescale fluctuations in dihydrofolate reductase are exquisitely sensitive to the bound ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Barrier passage and protein dynamics in enzymatically catalyzed reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

A 21st century revisionist's view at a turning point in enzymology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Coupling interactions of distal residues enhance dihydrofolate reductase catalysis: mutational effects on hydride transfer rates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Mass spectrometry of hydrogen/deuterium exchange of Escherichia coli dihydrofolate reductase: effects of loop mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Compartmental dispersion of enzymes in rat liver mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition state

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Application of a Theory of Enzyme Specificity to Protein Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

An iso-random Bi Bi mechanism for adenylate kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Direct Mg(2+) binding activates adenylate kinase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

NMR identification of transient complexes critical to adenylate kinase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Intrinsic motions along an enzymatic reaction trajectory

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Theory of the statistics of kinetic transitions with application to single-molecule enzyme catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Folding funnels and conformational transitions via hinge-bending motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Dynamical contributions to enzyme catalysis: critical tests of a popular hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Dynamic active-site protection by the M. tuberculosis protein tyrosine phosphatase PtpB lid domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

Differences in the chemical reactivity of individual molecules of an enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC0CP02412K

21 January 2018

Identifiers

DOI

10.1039/C0CP02412K

1 reference

23 August 2017

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