(Q39961656)

15 September 2017

A 21st century revisionist's view at a turning point in enzymology (English)

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15 September 2017

Zachary D Nagel

1

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PubMed ID

19620995

15 September 2017

Judith P Klinman

series ordinal

2

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15 September 2017

1 August 2009

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15 September 2017

Nature Chemical Biology

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15 September 2017

5

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15 September 2017

8

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15 September 2017

543-550

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https://scigraph.springernature.com/pub.10.1038/nchembio.204

15 September 2017

0 references

cites work

Molecular Architecture and Biological Reactions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

Electron transfers in chemistry and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures.

21 January 2018

1 reference

12 December 2020

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

1 reference

12 December 2020

Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex.

1 reference

12 December 2020

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

1 reference

12 December 2020

Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate

1 reference

12 December 2020

Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling.

1 reference

12 December 2020

Arrhenius curves of hydrogen transfers: tunnel effects, isotope effects and effects of pre-equilibria.

1 reference

12 December 2020

A protein structure from nuclear magnetic resonance data. lac repressor headpiece

1 reference

12 December 2020

An internal equilibrium preorganizes the enzyme-substrate complex for hydride tunneling in choline oxidase.

1 reference

12 December 2020

Relating protein motion to catalysis

1 reference

12 December 2020

Man-made enzymes--from design to in vitro compartmentalisation

1 reference

12 December 2020

Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited

1 reference

12 December 2020

Allosteric Interactions in Aspartate Transcarbamylase. II. Evidence for Different Conformational States of the Protein in the Presence and Absence of Specific Ligands

1 reference

12 December 2020

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

1 reference

12 December 2020

Large Kinetic Isotope Effects in Methane Oxidation Catalyzed by Methane Monooxygenase: Evidence for C−H Bond Cleavage in a Reaction Cycle Intermediate†

1 reference

12 December 2020

Selective chemical catalysis by an antibody

1 reference

12 December 2020

Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

1 reference

12 December 2020

Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase

1 reference

12 December 2020

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

1 reference

12 December 2020

Single-molecule enzymatic dynamics

1 reference

12 December 2020

Protein Design by Directed Evolution

1 reference

12 December 2020

Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair

1 reference

12 December 2020

Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

1 reference

12 December 2020

Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis

1 reference

12 December 2020

Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance

1 reference

12 December 2020

Structure of Hen Egg-White Lysozyme: A Three-dimensional Fourier Synthesis at 2 Å Resolution

1 reference

12 December 2020

Directed evolution of a glycosynthase via chemical complementation.

1 reference

12 December 2020

Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp. 1-IN

1 reference

12 December 2020

Hydrogen tunneling in enzyme reactions

1 reference

12 December 2020

Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase

1 reference

12 December 2020

Kemp elimination catalysts by computational enzyme design

1 reference

12 December 2020

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

1 reference

12 December 2020

Atomic detail of chemical transformation at the transition state of an enzymatic reaction

1 reference

12 December 2020

Enzymatic H-transfer requires vibration-driven extreme tunneling

1 reference

12 December 2020

Enzymatic transition states: thermodynamics, dynamics and analogue design

1 reference

12 December 2020

Two-dimensional reaction free energy surfaces of catalytic reaction: effects of protein conformational dynamics on enzyme catalysis.

1 reference

12 December 2020

Free-energy landscape of enzyme catalysis

1 reference

12 December 2020

On the relationship between folding and chemical landscapes in enzyme catalysis

1 reference

12 December 2020

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

1 reference

12 December 2020

Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase

1 reference

12 December 2020

Dynamic personalities of proteins

1 reference

12 December 2020

Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase

1 reference

12 December 2020

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

1 reference

12 December 2020

Critical analysis of antibody catalysis.

1 reference

12 December 2020

Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase

1 reference

12 December 2020

Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

1 reference

12 December 2020

Investigating and Engineering Enzymes by Genetic Selection

1 reference

12 December 2020

Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction

1 reference

12 December 2020

An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling

1 reference

12 December 2020

Nature of Rate-Limiting Steps in the Soybean Lipoxygenase-1 Reaction

1 reference

12 December 2020

Trading accuracy for speed: A quantitative comparison of search algorithms in protein sequence design

1 reference

12 December 2020

Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase

1 reference

12 December 2020

The Activated Complex in Chemical Reactions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

7 January 2021

Criterion of minimum state density in the transition state theory of bimolecular reactions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

7 January 2021

Ensemble-averaged variational transition state theory with optimized multidimensional tunneling for enzyme kinetics and other condensed-phase reactions

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

7 January 2021

Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid1-3

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

7 January 2021

On the Theory of Oxidation‐Reduction Reactions Involving Electron Transfer. I

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.204

7 January 2021

Identifiers

DOI

10.1038/NCHEMBIO.204

1 reference

PubMed ID

19620995

Dimensions Publication ID

15 September 2017

0 references

1 reference

PubMed ID

19620995