(Q46985231)

27 December 2017

title

Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase (English)

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27 December 2017

2

Arieh Warshel

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27 December 2017

Hanbin Liu

1

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27 December 2017

language of work or name

English

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publication date

16 June 2007

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27 December 2017

Journal of Physical Chemistry B

published in

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27 December 2017

volume

111

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27 December 2017

issue

27

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27 December 2017

page(s)

7852-7861

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27 December 2017

Enzymology takes a quantum leap forward

cites work

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Proton-coupled electron transfer in soybean lipoxygenase: dynamical behavior and temperature dependence of kinetic isotope effects.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

A link between protein structure and enzyme catalyzed hydrogen tunneling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

A combined quantum mechanical and molecular mechanical study of the reaction mechanism and alpha-amino acidity in alanine racemase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

How important are entropic contributions to enzyme catalysis?

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Nuclear quantum effects on an enzyme-catalyzed reaction with reaction path potential: proton transfer in triosephosphate isomerase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Effects of a distal mutation on active site chemistry

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Hydride transfer in liver alcohol dehydrogenase: quantum dynamics, kinetic isotope effects, and role of enzyme motion

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Dynamics of biochemical and biophysical reactions: insight from computer simulations

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

A crosslinked cofactor in lysyl oxidase: redox function for amino acid side chains.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Enzyme dynamics and tunneling enhanced by compression in the hydrogen abstraction catalyzed by soybean lipoxygenase-1

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Quantum mechanical effects in enzyme-catalysed hydrogen transfer reactions

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Hybrid quantum/classical path integral approach for simulation of hydrogen transfer reactions in enzymes.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Density-functional investigation on the mechanism of H-atom abstraction by lipoxygenase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Interpretation of resonance Raman spectra of biological molecules

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Enzymes: By chance, or by design?

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Extended spin-boson model for nonadiabatic hydrogen tunneling in the condensed phase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Through the channel and around the channel: Validating and comparing microscopic approaches for the evaluation of free energy profiles for ion penetration through ion channels

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Dynamics of enzymatic reactions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Proton-coupled electron transfer in soybean lipoxygenase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Dynamical contributions to enzyme catalysis: critical tests of a popular hypothesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Transition state theory can be used in studies of enzyme catalysis: lessons from simulations of tunnelling and dynamical effects in lipoxygenase and other systems

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Charge stabilization mechanism in the visual and purple membrane pigments

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Electrostatic basis for enzyme catalysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Environmentally coupled hydrogen tunneling. Linking catalysis to dynamics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Large kinetic isotope effects in enzymatic proton transfer and the role of substrate oscillations

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Simulations of the large kinetic isotope effect and the temperature dependence of the hydrogen atom transfer in lipoxygenase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Quantum mechanical methods for enzyme kinetics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1021/JP070938F

Identifiers

DOI

10.1021/JP070938F

1 reference

27 December 2017

PubMed ID

17571875

1 reference

27 December 2017