(Q37825577)

23 August 2017

1 reference

title

Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis (English)

1 reference

23 August 2017

0 references

Karel Tyml

1

1 reference

PubMed ID

21199094

23 August 2017

language of work or name

1 reference

1 February 2011

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23 August 2017

1 reference

23 August 2017

18

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23 August 2017

2

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23 August 2017

152-162

1 reference

Enzymatic function of nitric oxide synthases

23 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Bench-to-bedside review: microvascular dysfunction in sepsis--hemodynamics, oxygen transport, and nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Gram-negative sepsis. Background, clinical features, and intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Primary and secondary capture of platelets onto inflamed femoral artery endothelium is dependent on P-selectin and PSGL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Superoxide mediates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Oxidative stress promotes blood cell-endothelial cell interactions in the microcirculation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Treatment with N-acetylcysteine during acute respiratory distress syndrome: a randomized, double-blind, placebo-controlled clinical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Endothelial nitric oxide synthase in vascular disease: from marvel to menace

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbate protects endothelial barrier function during septic insult: Role of protein phosphatase type 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

NADPH oxidase mediates tissue factor-dependent surface procoagulant activity by thrombin in human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Insights into the redox control of blood coagulation: role of vascular NADPH oxidase-derived reactive oxygen species in the thrombogenic cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Microhemodynamic and cellular mechanisms of activated protein C action during endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Clinical practice guidelines for improving outcomes in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

3D visualization and measurement of capillaries supplying metabolically different fiber types in the rat extensor digitorum longus muscle during denervation and reinnervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Reactive oxygen species: players in the platelet game

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Microvascular perfusion is impaired in a rat model of normotensive sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Inflammation and coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Bidirectional relation between inflammation and coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Thrombin and tumor necrosis factor alpha synergistically stimulate tissue factor expression in human endothelial cells: regulation through c-Fos and c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Nitric oxide insufficiency, platelet activation, and arterial thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Reactive oxygen species: toxic molecules or spark of life?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

The epidemiology of sepsis in the United States from 1979 through 2000

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbate inhibits reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Bench-to-bedside review: circulating microparticles--a new player in sepsis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Increased expression of P-selectin on platelets is a risk factor for silent cerebral infarction in patients with atrial fibrillation: role of nitric oxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Tetrahydrobiopterin corrects Escherichia coli endotoxin-induced endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Platelet count decline: an early prognostic marker in critically ill patients with prolonged ICU stays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

From molecules to mammals: what's NOS got to do with it?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Inhibition of nitric oxide biosynthesis promotes P-selectin expression in platelets. Role of protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Unresolved roles of platelet nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Randomized, prospective trial of antioxidant supplementation in critically ill surgical patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Early lactate clearance is associated with improved outcome in severe sepsis and septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Vitamin C pharmacokinetics: implications for oral and intravenous use.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Blood volume determination in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Early goal-directed therapy in the treatment of severe sepsis and septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Platelet recruitment in the murine hepatic microvasculature during experimental sepsis: role of neutrophils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Augmented oxidative stress of platelets in chronic smokers. Mechanisms of impaired platelet-derived nitric oxide bioactivity and augmented platelet aggregability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Delayed ascorbate bolus protects against maldistribution of microvascular blood flow in septic rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Evolving concepts in sepsis definitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbate inhibits NADPH oxidase subunit p47phox expression in microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbate inhibits iNOS expression in endotoxin- and IFN gamma-stimulated rat skeletal muscle endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skeletal muscle of septic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Ascorbate protects against impaired arteriolar constriction in sepsis by inhibiting inducible nitric oxide synthase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

Lipopolysaccharide stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1549-8719.2010.00080.X

10.1111/J.1549-8719.2010.00080.X

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

21199094