(Q37826342)

23 August 2017

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title

Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention? (English)

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23 August 2017

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S P Kalra

1

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23 August 2017

6 January 2011

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23 August 2017

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23 August 2017

18

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23 August 2017

4

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23 August 2017

319-325

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https://scigraph.springernature.com/pub.10.1038/gt.2010.164

23 August 2017

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Central leptin differentially modulates ultradian secretory patterns of insulin, leptin and ghrelin independent of effects on food intake and body weight

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High-fat diet-induced ultradian leptin and insulin hypersecretion are absent in obesity-resistant rats.

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Leptin transport in the central nervous system.

21 January 2018

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21 January 2018

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Circumventing leptin resistance for weight control

21 January 2018

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Gene-transfer technology: a preventive neurotherapy to curb obesity, ameliorate metabolic syndrome and extend life expectancy

21 January 2018

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Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Leptin as an adjunct of insulin therapy in insulin-deficient diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Role of leptin in the cardiovascular and endocrine complications of metabolic syndrome.

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2010.164

Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy

21 January 2018

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https://api.crossref.org/works/10.1038%2FGT.2010.164

Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Single intracerebroventricular bolus injection of a recombinant adenovirus expressing leptin results in reduction of food intake and body weight in both lean and obese Zucker fa/fa rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Long-term correction of obesity and diabetes in genetically obese mice by a single intramuscular injection of recombinant adeno-associated virus encoding mouse leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Evidence for the existence of distinct central appetite, energy expenditure, and ghrelin stimulation pathways as revealed by hypothalamic site-specific leptin gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Leptin expression in hypothalamic PVN reverses dietary obesity and hyperinsulinemia but stimulates ghrelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

New recombinant serotypes of AAV vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Long-term suppression of weight gain, adiposity, and serum insulin by central leptin gene therapy in prepubertal rats: effects on serum ghrelin and appetite-regulating genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Suppression of fat deposition for the life time with gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Leptin gene transfer in the hypothalamus enhances longevity in adult monogenic mutant mice in the absence of circulating leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Differential effects of leptin in regulation of tissue glucose utilization in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Making insulin-deficient type 1 diabetic rodents thrive without insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Leptin therapy in insulin-deficient type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Leveraging leptin for type I diabetes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Central leptin gene therapy, a substitute for insulin therapy to ameliorate hyperglycemia and hyperphagia, and promote survival in insulin-deficient diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Perigestational suppression of weight gain with central leptin gene therapy results in lower weight F1 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Central leptin gene therapy corrects skeletal abnormalities in leptin-deficient ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Clinical gene therapy using recombinant adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

21 January 2018

The Epidemic of Obesity

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Acute stimulation of glucose metabolism in mice by leptin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

7 January 2021

Diabetes: treatment of type 2 diabetes mellitus with bariatric surgery

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

7 January 2021

WAT-free mice: diabetes without obesity

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

7 January 2021

Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

7 January 2021

Impaired transport of leptin across the blood-brain barrier in obesity

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

7 January 2021

Leptin and renal disease

1 reference

https://api.crossref.org/works/10.1038%2FGT.2010.164

7 January 2021

Identifiers

DOI

10.1038/GT.2010.164

1 reference

PubMed ID

21209624

Dimensions Publication ID

23 August 2017

0 references

1 reference

PubMed ID

21209624